Determination of metabolites products by Penicillium expansum and evaluating antimicobial activity

Hamza, Lena Fadhil; Kamal, Sabreen A.; Hameed, Imad Hadi

doi:10.5897/jpp2015.0360

Cited by 20 publications

(4 citation statements)

References 24 publications

(16 reference statements)

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“…Trybutyl acetylcitrate merupakan senyawa metabolit sekunder dengan rumus kimia C 20 H 34 O 8 yang terbukti memiliki kemampuan sebagai antioksidan. Senyawa ini juga telah dibuktikan oleh beberapa penelitian berpotensi sebagai antibakteri dan anti fungi (Olagunju et al 2006;Karthihwaran et al 2012;Hamza et al 2015). Ekstrak dari senyawa metabolit sekunder ini diketahui memiliki kemampuan dalam menghambat pertumbuhan dari bakteri patogen yaitu B. subtilis, P. aeruginosa, dan S. aureus.…”

Section: Hasilunclassified

Aktivitas Antibakteri dan Antioksidan dari Senyawa Bioaktif Asal Bakteri Endofit Tanaman Nyatoh (Palaquium amboinense B.)

Putra,

Retnowati,

Cordova

et al. 2024

JSDH

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Nyatoh plant (Palaquium amboinense B.) is native to Indonesia which is known to have the ability to produce potential secondary metabolites. The aim of this study was to evaluate the antibacterial and antioxidant activities from bioactive compounds produced by endophytic bacteria from nyatoh leaves. Five endophytic bacteria were tested against 4 targeted bacteria including Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 15442, Bacillus subtilis ATCC 19659, and Staphylococcus aureus ATCC 6538. Bacterial isolate which had the strongest antibacterial activity was then fermented and extracted. The corresponding extract was further tested on disc diffusion method, determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values, antioxidant evaluation, and analyzed for its bioactive compound components via GC-MS analysis. The results showed that one isolate, namely D1 can produce secondary metabolite which act as antibacterial and antioxidant potentials. This corresponding extract has the strongest MIC and MBC against B. subtilis with value of 39.5 and >78.1 µg/ml and exhibited antioxidant activity against 2,2-difenil-1-pikrilhidrazil (DPPH) with inhibition value of 85.37%. Based on GC-MS analysis, secondary metabolites derived from this potential extract contained some major active constituents including Tributyl acetylcitrate and bis (2-ethylhexyl) ester which might act as antibacterial and antioxidant agents.

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Section: Hasilunclassified

Aktivitas Antibakteri dan Antioksidan dari Senyawa Bioaktif Asal Bakteri Endofit Tanaman Nyatoh (Palaquium amboinense B.)

Putra,

Retnowati,

Cordova

et al. 2024

JSDH

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“…Diplobacillary forms are commonly found in vivo. [22] They have no specific growth requirements and grow well on standard laboratory media, but grow best between 35 and 37 °C and at pH 7.2. The species are facultative anaerobes, and most strains can survive with citrate and glucose as their sole carbon sources and ammonia as their sole nitrogen source.…”

Section: Klebsiellamentioning

confidence: 99%

Characterization of antimicrobial secondary metabolites produced by Klebsiella pneumoniae and screening of its bioactive natural compounds using gas chromatography-mass spectrometry (GC-MS)

Sajjad Saad Zghair,

Sahar Sarhan Thajeel,

Imad Hadi Hameed

2023

Int. J. Life Sci. Res. Arch.

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Microbial secondary metabolites are low molecular mass products with unusual structures. The structurally diverse metabolites show a variety of biological activities like antimicrobial agents. Thirty nine bioactive compounds were identified in the methanolic extract of Klebsiella pneumoniae. GC-MS analysis of Klebsiella pneumoniae revealed the existence of the Tricyclo[4.3.1.1(3.8)]undecan-1-amine, 3-Methoxybenzaldehyde semicarbazone, carboxaldehyde , 1-methyl-,oxime ,(Z)-(+), 1,5,5-Trimethyl-6-methylene-cyclohexene, 4-(2,5-Dihydro-3-methoxyphenyl)butylamine, Paromomycin , 9-Borabicyclo[3.31]nonane , 9-mercapto-, Benzenemethanol , 2-(2-aminopropoxy)-3-methyl, Acetamide , N-(6-acetylaminobenzothiazol-2-yl)-2-(adamantan, rin-6-carboxylic acid , 4-(2,5-Dihydro-3-methoxyphenyl)butylamine, N-(2,5-Dicyano-3,4-dihydro-2H-pyrrol-2-yl)-acetamide, 3,10-Dioxatricyclo [4.3.1.0(2,4)]dec-7-ene, 3-Cyclohex-3-enyl-propionic acid, Eicosanoic acid ,phenylmethyl ester, 3,7-Diazabicyclo[3.3.1]nonane , 9,9-dimethyl-, Dithiocarbamate , S-methyl-,N-(2-methyl-3-oxobutyl)-, dl-Homocysteine, 2-(2-Furyl)pyridine, 1,7-Dioxa-10-thia-4,13-diazacyclopentadeca-5,9,12-trione, 5,7-Dodecadiyn-1,12-diol, 1-(β-d-Arabinofuranosyl)-4-O-difluoromethyluracil, Uric acid, Pyrrolo[1.2-a]pyrazine-1,4-dione , hexahydro-,12-Methyl-oxa-cyclododecan-2-one, Phthalic acid , butyl undecyl ester, 9,12,15-Octadecatrienoic acid , 2,3-bis(acetyloxy)propyl ester, 1,2,4-Trioxolane-2-octanoic acid 5-octyl-, methyl ester, 12-Dimethylamino-10-oxododecanoic acid , Octahydrochromen-2-one, L-Aspartic acid , N-glycyl-,2H-Oxecin-2-one , 3,4,7,8,91,10-hexahydro-4-hydroxy-10-meth , Thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione , 2-amino-4-(2-ph, Dec-9-en-6-oxo-1-ylamide, 3,6,12-Trimethyl-1,4,7,10,13,16-hexaaza-cyclooctadecane, 2-lodohiistidine, 2,5-Piperazinedione ,3,6-bis(2-methylpropyl)-, 9-Octadecenamide , (Z)-, 3',8,8'-Trimethoxy-3-piperidyl-2,2'-binaphthalene-1,1',4,4'-tetra. Clinical pathogens selected for antibacterial activity namely, Streptococcus pneumonia, Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Staphylococcus epidermidis, It were 4.09±0.013, 2.99±0.300, 4.37±0.200, 3.22±0.210, and 4.00±0.203 respectively for Bacterial products (Metabolites Produced by Klebsiella pneumoniae), while recorded 1.08±0.200, 0.97±0.116, 2.08±0.233, 3.04±0.261, 0.98±0.166 respectively for Bacterial products Streptomycin antibiotics, and recorded 1.02±0.180, 1.00±0.190, 2.08±0.236, 1.00±0.100, and 1.82±0.200 respectively for Kanamycin antibiotics. Klebsiella pneumoniae produce many important secondary metabolites with high biological activities. Based on the significance of employing bioactive compounds in pharmacy to produce drugs for the treatment of many diseases, the purification of compounds produced by Klebsiella pneumoniae can be useful.

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“…One of the most crucial new enzymes for the commercial sector, particularly for the fruit juice business, is pectinases. Juices with higher yields, more stability and better clarity are certain to be produced as a result (Girard and Fukumoto (1999) [90] . Amylases, glucoamylases, cellulases, hemicellulose, laccase, naringinase and limonene are other examples of enzymes utilized in the juice industry.…”

Section: Utilization Of Enzymes In Bakery Technologymentioning

confidence: 99%

Biochemical impact of microorganism and enzymatic activities in food and pharmaceutical industries

Umaru¹,

Adam²,

Habibu³

et al. 2021

Int. J. Adv. Biochem. Res.

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Bio catalytic activity of microorganisms and enzymes have been explored for centuries to yield bread, wine, vinegar and with some common products without knowledge about the biochemical basis of their properties. Due to their established catalytic activity, stability, simplicity of biosynthesis and higher optimization when compared with plants and animal enzymes, microbes and enzymes are now widely used in the food and medical industries. Enzymes usage across diverse industries (such as food, agriculture, chemicals, and medicines) is rapidly on the increase owing to their characteristic rapid processing time, low energy requirements, affordability, non-toxic and environmental friendliness. Therefore, toxic chemicals from the domestic environment and various industries (e.g. phenols, nitriles and amines) can be degraded or converted by microbes. This review is geared towards discussing the present-day technical and scientific involvement of ubiquitous organisms (microorganisms) and the production of enzymes with their present status in global enzyme market among various industries.

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Determination of metabolites products by Penicillium expansum and evaluating antimicobial activity

Cited by 20 publications

References 24 publications

Aktivitas Antibakteri dan Antioksidan dari Senyawa Bioaktif Asal Bakteri Endofit Tanaman Nyatoh (Palaquium amboinense B.)

Aktivitas Antibakteri dan Antioksidan dari Senyawa Bioaktif Asal Bakteri Endofit Tanaman Nyatoh (Palaquium amboinense B.)

Characterization of antimicrobial secondary metabolites produced by Klebsiella pneumoniae and screening of its bioactive natural compounds using gas chromatography-mass spectrometry (GC-MS)

Biochemical impact of microorganism and enzymatic activities in food and pharmaceutical industries

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