Determination of methadone in human hair by radioimmunoassay

Balabanova, S.; Wolf, H. U.

doi:10.1007/bf00201255

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…Radioimmunoassay (RIA) was initially employed for screening hair samples for drugs of abuse, 68,89–91 but the majority of laboratories have now replaced RIA with enzyme-linked immunosorbent assays (ELISA). 92 Immunoassays originally developed for whole blood have been adapted or optimized specifically for hair.…”

Section: Discussionmentioning

confidence: 99%

Hair testing is taking root

Cooper

2011

Ann Clin Biochem

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An increasing number of toxicology laboratories are choosing to expand the services they offer to include hair testing in response to customer demands. Hair provides the toxicologist with many advantages over conventional matrices in that it is easy to collect, is a robust and stable matrix that does not require refrigeration, and most importantly, provides a historical profile of an individual's exposure to drugs or analytes of interest. The establishment of hair as a complementary technique in forensic toxicology is a direct result of the success of the matrix in medicolegal cases and the wide range of applications. However, before introducing hair testing, laboratories must consider what additional requirements they will need that extend beyond simply adapting methodologies already validated for blood or urine. Hair presents many challenges with respect to the lack of available quality control materials, extensive sample handling protocols and low drug concentrations requiring greater instrument sensitivity. Unfortunately, a common pitfall involves over-interpretation of the findings and must be avoided.

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Section: Discussionmentioning

confidence: 99%

Hair testing is taking root

Cooper

2011

Ann Clin Biochem

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“…The presence of methadone in human hair was demonstrated by radioimmunologic method (Balabanova and Wolf 1988) but not by GC/MS. This study described the determination of methadone alone in human hair by GC/MS.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, we have described the determination of methadone in human hair by radioimmunoassay (Balabanova and Wolf 1988). The method described is sensitive, simple, and rapid.…”

Section: Introductionmentioning

confidence: 99%

Detection of methadone in human hair by gas chromatography/mass spectrometry

Balabanova

Arnold²,

Brunner

et al. 1989

Z Rechtsmed

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Summary. Determination of methadone in human hair by gas chromatography/ mass spectrometry was described. Helium as carrier gas, a 30-m bonded phasefused silica DB-1 capillary column and splitless injection at 230°C temperature were used. The concentrations of methadone and its metabolites were measured in addition by radioimmunoassay (RIA). Both methods GC/MS and RIA showed the presence of methadone in human hair. Key word: Methadone, in human hairZusammenfassung. In dieser Arbeit wurde die Bestimmung von Methadon in menschlichen Haaren mittels Gaschromatographie/Massenspektrometrie (GC/MS) beschrieben. Als Tr~igergas wurde Helium benatzt; die S/iule war eine Kapillars/~ule DB-1 un die Injektion eine Splitlos-Injektion, bei einer Verdampfungstemperatur von 230°C. Die Methadonkonzentrationen in den Haaren wurden auch mittels Radioimmunoassay (RIA) durchgeftihrt. Beide Methoden GC/MS und RIA zeigen das Vorhandensein des Methadons im menschlichen Haar. Schliisseiwort: Methadon, im menschlichen Haar

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“…Recently, we reported also the presence of methadon in human hair obtained from patients receiving daily methadone (Balabanova and Wolf 1988). However, data on the occurence of the drug in axillary and pubic hair are not available.…”

Section: Introductionmentioning

confidence: 94%

“…Determination of drugs in hair of the head has been documented (Baumgartner et al 1979;Klug 1980;Baumgartner et al 1981;Smith and Pomposini 1981;Valente et al 1981;Baumgartner et al 1982;Piischel et al 1983;Smith and Liu 1986;Balabanova et al 1987;Balabanova and Wolf 1988).…”

Section: Introductionmentioning

confidence: 97%