Determination of Methimazole on a Multiwall Carbon Nanotube Titanium Dioxide Nanoparticle Paste Electrode

Fouladgar, Masoud; Mohammadzadeh, Safoora

doi:10.1080/00032719.2013.855782

Cited by 25 publications

(9 citation statements)

References 50 publications

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“…In addition, the active surface area of modified and non-modified electrodes CuO/1E3MIBF 4 /CPE, 1E3MIBF 4 /CPE, CuO/CPE and CPE was obtained based on the Randles-Sevcik equation (in the presence of 1 mM K 4 Fe(CN) 6 ). 32 The active surface areas of CPE, CuO/CPE, 1E3MIBF 4 /CPE and CuO/1E3MIBF 4 /CPE were calculated equals; 0.28, 0.31, 0.32 and 0.33 cm 2 , respectively.…”

Section: Effect Of Modificationmentioning

confidence: 99%

“…[27][28][29][30][31] One of the effects of application of nanomaterials is due to the change in the active surface area of electrodes. [32][33][34] This effect and some other effects that appear when the size of particles decreases to nanoscale, cause to improve performance of electrochemical methods. 35 However, application of nanoparticles may have disadvantage effect on the electrochemical signals and increases background currents.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Electrochemical CuO-Nanostructure Platform for Simultaneous Determination of 6-thioguanine and 5-fluorouracil Anticancer Drugs

Fouladgar¹

2020

ACSi

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Analysis of anticancer drugs is very important and necessary for the correct administration of them in the human body. Electrochemical behavior of 6-thioguanine (6-TG) has been studied using a carbon paste electrode modified by 1-ethyl-3-methylimidazolium tetrafluoroborate (ionic liquid) (1E3MIBF4) and CuO nanoparticles (CuO/1E3MIBF4/ CPE). Using square wave voltammetry showed the linear relation between net anodic current and concentration of 6-TG in the range of 70 nmol L −1 to 520 µmol L −1 6-TG with the detection limit of 20 nmol L −1 6-TG. The proposed modified electrode had excellent repeatability (RSD = 1.31%, n = 5) and long term stability (2.9% deviation in 25 days). The diffusion coefficient of 6-TG on the CuO/1E3MIBF4/CPE was found to be 1.54 × 10 −5 cm 2 s −1 .The CuO/1E3MIBF4/ CPE was successfully applied for the determination of 6-TG in real samples. In addition, the anodic peaks of 6-TG and fluorouracil (5-FU) in their mixture can be well separated using CuO/1E3MIBF4/CPE and simultaneous determination of them was studied.

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Section: Effect Of Modificationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical CuO-Nanostructure Platform for Simultaneous Determination of 6-thioguanine and 5-fluorouracil Anticancer Drugs

Fouladgar¹

2020

ACSi

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“…Various methods based on different analytical procedures have been described in literature for the determination of methimazole including Ultraviolet-Visible (UV-Vis) spectrophotometry [2][3][4][5][6][7], derivative spectrophotometry [8], Raman spectroscopy [9,10], resonance light scattering spectroscopy [11], chemiluminescence [12][13][14], fluorescence [15,16], capillary electrophoresis [17], immunoassay [18], molecularly imprinted biomimetic sensing [19], Thin Layer Chromatography (TLC) [20] and High Performance Liquid Chromatography (HPLC) [21][22][23][24][25]. Methimazole has been also determined using electrochemical methods by using different chemically modified electrodes through introducing various electron mediators on its surface [26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Novel Selective Spectrophotometric Methods for the Determination of Methimazole in Pure Form and in Pharmaceutical Formulation

Bathish

Gazy

Jamal

2019

Int J Pharm Pharm Sci

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Objective: To develop and validate new, selective spectrophotometric colorimetric analytical methods for the quantification of methimazole in its pure form and in its pharmaceutical preparations. Methods: Method A is based on the oxidation of methimazole with potassium permanganate in alkaline medium, the manganate ion produced was measured at λmax= 610 nm. Method B is a kinetic determination of methimazole using fixed-time method based on the oxidation of methimazole using known excess of cerium (IV) nitrate in acidic medium and assessing the unreacted Ce (IV) by adding a fixed amount of methyl orange and measuring the absorbance of the resultant solution at λmax=507 nm which is equivalent to the unreacted methyl orange. The reaction conditions and analytical parameters are investigated and optimized. Method validation was carried out according to ICH guidelines in terms of linearity, LOD, LOQ, precision, and accuracy. Results: Beer’s law is obeyed in the range of 1.50–15.00 μg/ml for method A and 0.25–3.00 μg/ml for method B. The developed methods were subjected to the detailed validation procedure. The proposed spectrophotometric methods were applied for the determination of the methimazole in its pure form and in its pharmaceutical formulation. The percentage recoveries were found to be 100.82 % and 99.85 % in the pharmaceutical formulation for the two proposed methods, respectively. Conclusion: Both developed spectrophotometric methods, considered as green analytical chemistry, were found to be novel, highly selective and can be applied for the quality control of methimazole in its pure form and in its pharmaceutical formulation based on the simplicity, applicability of the parameters, accessibility of the reagents employed and reasonably low time of analysis.

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“…inset shows the current densities derived from cyclic voltammograms at the surface of different electrodes confirm catalytic ability of IL/NiO/CNT/CPE. In addition the active surface area of carbon paste electrode and modified electrodes were obtained by cyclic voltammetry using K 3 Fe(CN) 6 as a probe at different scan rates[25] .The results obtained were as follows:0.09, 0.16, 0.17 and 0.22 cm 2 for CPE, NiO/CNT/CPE, IL/CPE and IL/NiO/CNT/CPE, respectively.To study the effect of potential scan rate (v) on the oxidation current, cyclic voltammograms of 300 mol L −1 NA (pH=7.0) were recorded at IL/NiO/CNT/CPE with different scan rates (Figure 4). The results showed that there was a linear relationship between the peaks current and the square root of scan rateaccording to regression equationof:I pa =0.5899 v 1/2 +1.4608 (R 2 =0.994, I pa in A and v inmVs −1 )This linear relation indicated that the electrode process is controlled under the diffusion step.In order to calculate transfer coefficient (α), Tafel plotswere developed for IL/NiO/CNT/CPE using the data derived from the raising part of the current-voltage curves with two scan rates (Figure 5).The slope of the Tafel plot is equal to 2.3RT/ n(1−α)F .…”

mentioning

confidence: 99%

A new sensor for determination of nalbuphine using NiO/functional single walled carbon nanotubes nanocomposite and ionic liquid

Fouladgar

2016

Sensors and Actuators B: Chemical

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Using a NiO/functional single walled carbon nanotubes nanocomposite incorporated with ionic liquid (IL/NiO/CNT/CPE), we prepared a sensitive and selective sensor for determination of nalbuphine (NA). Nalbuphine is a semisynthetic analgesic drug. Electrochemical investigations showed that the nanocomposite had catalytic effect on oxidation of nalbuphine and enhanced the oxidation current. This modified electrode had linear dynamic range from 0.2-500.0 mol L −1 NA with detection limit of 0.07 mol L −1 NA. Selectivity of the sensor has been studied and proposed method has been applied for determination of nalbuphine in biological samples.

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Determination of Methimazole on a Multiwall Carbon Nanotube Titanium Dioxide Nanoparticle Paste Electrode

Cited by 25 publications

References 50 publications

A Novel Electrochemical CuO-Nanostructure Platform for Simultaneous Determination of 6-thioguanine and 5-fluorouracil Anticancer Drugs

A Novel Electrochemical CuO-Nanostructure Platform for Simultaneous Determination of 6-thioguanine and 5-fluorouracil Anticancer Drugs

Novel Selective Spectrophotometric Methods for the Determination of Methimazole in Pure Form and in Pharmaceutical Formulation

A new sensor for determination of nalbuphine using NiO/functional single walled carbon nanotubes nanocomposite and ionic liquid

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