Determination of Methotrexate at a Silver Solid Amalgam Electrode by Differential Pulse Voltammetry

Janíková-Bandžuchová, Lenka; Šelešovská, Renáta

doi:10.1080/00032719.2014.996812

Cited by 14 publications

(6 citation statements)

References 42 publications

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“…For example, modification of GCE with CoFe 2 O 4 /reduced graphene oxide (rGO) and ionic liquid in phosphate buffer solution (PBS) at pH 2.5 [142], modification of GCE with poly l -lysine in the presence of sodiumdodecyl benzene sulfonate (SDBS) [143], AdSDPV technique along with a bismuth film electrode (BiFE) [144], synthesized nanocomposites of N–graphene coated with a bimetallic palladium-silver alloy (PdAg/NG–GCE) [145], 3D porous graphene-carbon nanotube (G-CNT) network on the surface of GCE [146], modification of GCE with cyclodextrin-graphene hybrid nanosheets [147] achieved LODs in the range of 0.01–70 nM. Studies reporting electrochemical methods are listed in Table 4 [[148], [149], [150], [151], [152], [153]].…”

Section: Electrochemical Methodsmentioning

confidence: 99%

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples

Karami

Ranjbar

Ghasemi

et al. 2019

Journal of Pharmaceutical Analysis

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Methotrexate (MTX) is a folate antagonist drug used for several diseases, such as cancers, various malignancies, rheumatoid arthritis (RA) and inflammatory bowel disease. Due to its structural features, including the presence of two carboxylic acid groups and its low native fluorescence, there are some challenges to develop analytical methods for its determination. MTX is metabolized to 7-hydroxymethotrexate (7-OH-MTX), 2,4-diamino-N10-methylpteroic acid (DAMPA), and the active MTX polyglutamates (MTXPGs) in the liver, intestine, and red blood cells (RBCs), respectively. Additionally, the drug has a narrow therapeutic range; hence, its therapeutic drug monitoring (TDM) is necessary to regulate the pharmacokinetics of the drug and to decrease the risk of toxicity. Due to environmental toxicity of MTX; its sensitive, fast and low cost determination in workplace environments is of great interest. A large number of methodologies including high performance liquid chromatography equipped with UV–visible, fluorescence, or electrochemical detection, liquid chromatography-mass spectroscopy, capillary electrophoresis, UV–visible spectrophotometry, and electrochemical methods have been developed for the quantitation of MTX and its metabolites in pharmaceutical, biological, and environmental samples. This paper will attempt to review several published methodologies and the instrumental conditions, which have been applied to measure MTX and its metabolites within the last decade.

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Section: Electrochemical Methodsmentioning

confidence: 99%

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples

Karami

Ranjbar

Ghasemi

et al. 2019

Journal of Pharmaceutical Analysis

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“…[1][2][3][4] However, the clinical utilization of ATP is generally limited due to the serious side reactions since ATP with high-dose can induce ulcerative stomatitis, low white blood cells, liver damage and even cause life threatening. [5][6][7] As a consequence, monitoring the ATP concentration in human blood is very helpful to achieve the optimized drug dosage, which presents maximum therapeutic effect but minimum toxicity.…”

Section: Introductionmentioning

confidence: 99%

Simple, low-cost and sensitive electrochemical sensing of antineoplastic drug amethopterin based on a nanocarbon black modified electrode

Lin

Zhang

et al. 2022

Anal. Methods

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“…This is now possible due to the manipulation of materials at the atomic level because of revolutionary advancements in the field of nanotechnology. For this purpose, intensive efforts are used to fabricate earth-abundant and low-cost metal oxide nanostructures such as NiO, CuO, TiO 2 , ZnO, and their hybrid structures with enhanced electrochemical activities [ 35 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. Nanostructured materials offer a high surface area for the sensing applications; thus, different morphologies at the nano level have shown outperforming properties in sensing electronics and optoelectronics applications [ 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Electrochemical Determination of Methotrexate (MTX) Using Glassy Carbon Electrode-Modified with Electronically Disordered NiO Nanostructures

et al. 2021

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Recently, the oxidative behavior of methotrexate (MTX) anticancer drug is highly demanded, due to its side effects on healthy cells, despite being a very challenging task. In this study, we have prepared porous NiO material using sodium sulfate as an electronic disorder reagent by hydrothermal method and found it highly sensitive and selective for the oxidation of MTX. The synthesized NiO nanostructures were characterized by scanning electron microscope (SEM) and X-ray diffraction (XRD) techniques. These physical characterizations delineated the porous morphology and cubic crystalline phase of NiO. Different electrochemical approaches have been utilized to determine the MTX concentrations in 0.04 M Britton–Robinson buffer (BRB) at pH 2 using glassy carbon electrode (GCE)-modified with electronically disordered NiO nanostructures. The linear range for MTX using cyclic voltammetry (CV) was found to be from 5 to 30 nM, and the limit of detection (LOD) and limit of quantification (LOQ) were 1.46 nM and 4.86 nM, respectively, whereas the linear range obtained via linear sweep voltammetry (LSV) was estimated as 15–90 nM with LOD and LOQ of 0.819 nM and 2.713 nM, respectively. Additionally, amperometric studies revealed a linear range from 10 to70 nM with LOD and LOQ of 0.1 nM and 1.3 nM, respectively. Importantly, MTX was successfully monitored in pharmaceutical products using the standard recovery method. Thus, the proposed approach for the synthesis of active metal oxide materials could be sued for the determination of other anticancer drugs in real samples and other biomedical applications.

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Determination of Methotrexate at a Silver Solid Amalgam Electrode by Differential Pulse Voltammetry

Cited by 14 publications

References 42 publications

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples

Simple, low-cost and sensitive electrochemical sensing of antineoplastic drug amethopterin based on a nanocarbon black modified electrode

Facile Electrochemical Determination of Methotrexate (MTX) Using Glassy Carbon Electrode-Modified with Electronically Disordered NiO Nanostructures

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