Determination of metronidazole in pharmaceutical dosage forms based on reduction at graphene and ionic liquid composite film modified electrode

Peng, Jinyun; Hou, Chaohuan; Hu, Xiaoyun

doi:10.1016/j.snb.2012.03.040

Cited by 111 publications

(45 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be seen in Figure 3c that the peak potential values shifts towards more negative values up to pH = 10. This finding is in complete agreement with previous reports [9,32].…”

Section: Effect Of Phsupporting

confidence: 94%

“…As can be seen, the electrochemical reaction of MTZ is an irreversible process with a reduction peak potential of -0.59 V vs. SCE. This is consistent with that reported in the literature [9]. The peak current value (Ip) of MTZ at GR-TiO2 modified electrode is larger than that of other modified electrodes (Figure 2d).…”

Section: Electrochemical Properties Of Gr-tio2 Modified Electrodessupporting

confidence: 92%

“…The α value for this reaction was calculated to be 0.694. This finding is consistent with the findings of previous research [9]. For thin layer voltammetry, the total amount of charge passed through the electrode surface (Q) for the reduction of MTZ was obtained by integration of CV peaks.…”

Section: Effect Of Scan Ratesupporting

confidence: 92%

“…(2-methyl-5-nitroimidazole-1-ethanol, MTZ) is a nitroimidazole antibiotic, which is used particularly for protozoal and an aerobic bacterial infections [9,19].Several methods have been stated for the measurement of metronidazole including spectrophotometry [20][21][22][23][24], high performance liquid chromatography (HPLC) [25][26][27][28] and gas chromatography [29,30]. MTZ can also be electrochemically investigated by the reduction of its nitro group (Scheme 1).…”

Section: Metronidazolementioning

confidence: 99%

“…Recently graphene (GR), which consists of two-dimensional sheets of sp 2 hybridized carbon atoms, has attracted enormous attention from scientists. Because of its large surface area, excellent thermal and electrical conductivity, high mobility of charge carriers, high mechanical strength and elasticity, GR is used as an excellent electrode modifier [7][8][9]. On the other hand nanocrystalline TiO2 films and membranes have good structural and catalytic properties, such as high surface area and good biocompatibility [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

et al. 2015

View full text Add to dashboard Cite

In the present work, a new Graphene-TiO2 (GR-TiO2) modified glassy carbon electrode (GCE) is suggested for sensitive electrochemical determination of metronidazole (MTZ). Electrochemical studies revealed that GR-TiO2 nanoparticles increased the efficiency of electron transfer kinetics by increasing the available surface area of the electrode and charge mobility between MTZ and GR-TiO2 modified electrode. Compared to bare GCE, the modified electrode greatly enhanced the reduction signal of MTZ. The electrochemical behaviour of the modified electrode and the electrochemical reduction of MTZ were investigated with electrochemical impedance spectroscopy, cyclic voltammetry and differential pulse voltammetry techniques. The charge transfer coefficient (α) was calculated to be 0.694. Under optimized conditions, the linear concentration range and detection limit of MTZ were 5.0×10 -7 to 2.5×10 -5 M -1 and 5.4×10 -8 (S/N = 3), respectively. Finally, this sensing method was successfully applied for the determination of MTZ in human blood serum and urine samples.

show abstract

“…It can be seen in Figure 3c that the peak potential values shifts towards more negative values up to pH = 10. This finding is in complete agreement with previous reports [9,32].…”

Section: Effect Of Phsupporting

confidence: 94%

Section: Electrochemical Properties Of Gr-tio2 Modified Electrodessupporting

confidence: 92%

Section: Effect Of Scan Ratesupporting

confidence: 92%

Section: Metronidazolementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

et al. 2015

View full text Add to dashboard Cite

show abstract

Application of peptide nucleic acid in electrochemical nucleic acid biosensors

2021

View full text Add to dashboard Cite

The early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival rate of patients and reduce medical costs. Therefore, the development of a simple detection method with high sensitivity and strong specificity, and that is low cost is of great significance for the diagnosis and prognosis of the disease. Electrochemical DNA biosensing analysis is a technology based on Watson Crick base complementary pairing, which uses the capture probe of a known sequence to specifically recognize the target DNA and detect its concentration. Because of its advantages of low cost, simple operation, portability, and easy miniaturization, it has been widely researched and has become a cutting-edge topic in the field of biochemical analysis and precision medicine. However, the existing methods for electrochemical DNA biosensing analysis have some shortcomings, such as poor stability and specificity of capture probes, insufficient detection sensitivity, and long detection cycles. In this review, we focus on improving the sensitivity and practicability of electrochemical DNA biosensing analysis methods and summarize a series of research work carried out by using electrically neutral peptide nucleic acid as an immobilized capture probe.

show abstract

High Performance Electrocatalyst Based on MIL‐101(Cr)/Reduced Graphene Oxide Composite: Facile Synthesis and Electrochemical Detections

Yin

et al. 2018

ChemElectroChem

View full text Add to dashboard Cite

In this work, a Cr-based MOF (MIL-101(Cr))/reduced grapheme oxide(rGO) electrocatalyst was prepared through a one-pot hydrothermal method. The obtained composite was characterized via scanning electron microscopy, transmission electron microscopy, X-ray diffraction and other standard techniques. Electrochemical methods were adopted to study the electrocatalytic ability of the composite. The results imply that, compared to the single components, it exhibits higher electrocatalytic activity for the reduction of metronidazole and stripping of Cd 2 + and Pb 2 + . Optimizing the ratio of MIL-101(Cr) and rGO, an electrochemical sensor was prepared using MIL-101 (Cr)/rGO-20 and used for detection of metronidazole, Cd 2 + and Pb 2 + , respectively. The linear range for metronidazole can be divided in two parts, i. e. from 0.5 to 200 mM and from 200 to 900 mM. The limit of detection is 0.24 mM (S/N = 3, n = 10). Likewise, it also exhibits a wide linear range from 0.05 to 6.0 mM for the detection of Cd 2 + and Pb 2 + . The corresponding detection limits are found to be 5.2 nM and 3.0 nM (S/N = 3, n = 10), respectively. The proposed sensor also possesses superb selectivity, reproducibility, stability and can be applied to detect real samples with desired recovery rates. In addition, the possible reduction mechanism of metronidazole and adsorption mechanism of Cd 2 + and Pb 2 + were further discussed simply in this work.[a] J.

show abstract

Determination of metronidazole in pharmaceutical dosage forms based on reduction at graphene and ionic liquid composite film modified electrode

Cited by 111 publications

References 40 publications

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples

Application of peptide nucleic acid in electrochemical nucleic acid biosensors

High Performance Electrocatalyst Based on MIL‐101(Cr)/Reduced Graphene Oxide Composite: Facile Synthesis and Electrochemical Detections

Contact Info

Product

Resources

About