Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors

Taylor, PW; Schoenknecht, Fritz D.; Sherris, John C.; Linner, E C

doi:10.1128/aac.23.1.142

Cited by 202 publications

(135 citation statements)

References 31 publications

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“…Although great care was taken in performing these tests, results were often inconsistent, especially with staphylococci, owing to methodological problems (see Taylor et al, 1983). We therefore decided to study the bactericidal potential of the drug in a kinetic system.…”

Section: Bactericidal Activity Of Meropenemmentioning

confidence: 99%

Activity of meropenem, against Gram-positive bacteria

Kayser

Morenzoni

Strässle

et al. 1989

Journal of Antimicrobial Chemotherapy

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A new carbapenem antibiotic, meropenem, was shown to be active against a large number of Gram-positive bacteria. The drug inhibited penicillinase-positive and -negative, methicillin-susceptible staphylococti equally well. Among the comparative antimicrobials examined, only Af-formimidoyl-thienamycin (imipenem) was two to four times more active than meropenem. Compared with vancomycin or methicillin, meropenem was 10-20 times more active. Strains of 11 species of streptococci were highly susceptible to meropenem; the geometric mean MICs of the drug for these species ranged from 0-01 to 0-04 mg/1. The agent, however, only had moderate activity against Enterococcus faecalis (mean MIC 5 mg/1) and Ent.faecium (mean MIC 11-6 mg/1). Among Corynebacterium jeikeium, strains were encountered that showed susceptibility to meropenem but resistance to imipenem and other /Jlactams. Strains of other corynebacteria, Rhodococcus equi, Erysopelothrix rhusiopathiae, Listeria monocytogenes, and Bacillus spp. all were highly susceptible to meropenem (mean MICs 0-04-0-17 mg/1). Although methicillin-resistant staphylococci were inhibited by concentrations of 1-2 mg/1 of meropenem in agar dilution tests, such strains showed heteroresistance in population studies, as is typical for all /J-lactam antibiotics. In addition, the biochemical correlate of methicillin-resistance, penicillin-binding protein 2', showed low affinity for meropenem, similar to that for imipenem. Meropenem was as bactericidal as imipenem and comparative bactericidal antimicrobials in killing-curve experiments. Strains of Ent.faecium, C. jeikeium, and L. monocytogenes were killed at a slower rate than streptococci or staphylococci.

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Section: Bactericidal Activity Of Meropenemmentioning

confidence: 99%

Activity of meropenem, against Gram-positive bacteria

Kayser

Morenzoni

Strässle

et al. 1989

Journal of Antimicrobial Chemotherapy

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“…Sch 34343 was as bactericidal as comparative agents (flucloxacillin, ampicillin and penicillin (G) against representative Gram-positive bacteria in the kinetic studies. The variable results obtained with Sch 34343 and the comparative drugs in conventional MBC 99-9% tests reflect the laboratory problems connected with this procedure (Taylor et al, 1983;Kayser & Muller, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…Examination of the bactericidal activity of Sch 34343 and comparative agents was carried out in conventional MBC tests (Anhalt, Sabath & Barry, 1980) in triplicate Although great care was taken in performing these tests, results were often inconsistent, due to multiple methodological problems (Taylor et al, 1983;Kayser & Mtiller, 1983). Table II summarizes some of the results obtained.…”

Section: Bactericidal Activity Of Sch 34343mentioning

confidence: 99%

Comparative activity of the penem antibiotic Sch 34343 against Gram-negative and Gram-positive bacteria with special reference to multiresistant strains

Kayser

Novak

Strässle

1985

Journal of Antimicrobial Chemotherapy

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A new penem antibiotic, Sch 34343, was shown to be active against a large number of Gram-positive bacteria. The drug inhibited peniciUinase-positive and -negative staphylococci equally well, being five times more active than cefamandole and ten times more active than methiallin. Most methicillin-resistant staphylococci were inhibited by concentrations between 0-25 and 4 mg/1, but a small group of highly resistant strains were observed. Sch 34343 was eight times less active than ampicillin and penicillin G, but as active as piperacilhn against enterococci. The drug showed excellent activity against various streptococci. Sch 34343 was as bactericidal as flucloxacilhn, ampicillin and penicillin G against staphylococci, enterococci and streptococci, respectively, in lulling kinetic tests Enterobacteriaceae susceptible to third-generation cephalosporins were approximately five times less susceptible to Sch 34343, but MICs were far below the susceptibility breakpoint Sch 34343 was equally active against Citrobacter and Enterobacter strains that were highly resistant to third-generation cephalosporins and to aztreonam. Together with thienamycin, this drug seems to be a good alternative for the treatment of infections caused by bacteria resistant to thirdgeneration cephalosporins and to aztreonam.

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“…22 MBC is defined as the concentration resulting from the reduction of 99.9% mg/ml of the initial bacterial inoculum, meaning that only 0.1% of bacteria will survive when cultures in a new MHA medium. 20 The number of bacterial colonies connecting it to 0.1% in the initial bacterial inoculum-broth microdilution test, where 0.1% is roughly equivalent to a number of bacteria of 8 CFU. The MBC value of β-glucan extract (laminaran) is shown in Table 3.…”

Section: Test Mic and Mbcmentioning

confidence: 99%

“…MBC is defined as the concentration resulting from the reduction of 99.9% of the initial bacterial inoculum, thus allowing only 0.1% of bacteria to stay alive when recultured in a new MHA medium. 20 The number of bacterial colonies related to 0.1% of the previous bacterial inoculum in the broth microdilution test was calculated, where 0.1% of approximately 8 CFU showed less than or equal growth of bacterial colonies on media MHA known as MBC values (mg/ml). The lowest concentration of the extract showed no bacterial growth on agar plates referring to the MBC of each extract.…”

Section: Mbc (Minimum Bactericidal Concentrations) Testmentioning

confidence: 99%

Antibacterial activities of β-glucan (laminaran) against gram-negative and gram-positive bacteria

Chamidah¹,

Hardoko²,

Prihanto³

2017

AIP Conference Proceedings

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The effect of oyster mushroom (Pleurotus ostreatus) powder as prebiotic agent on yoghurt quality AIP Conference Proceedings 1844, 030006 (2017) Abstract. This study aimed to determine the antibacterial activity of β-Glucan (laminaran) of LAE and LME extracts from brown algae Sargassum crassifolium using HPMS and Ultrasonication against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Salmonella typhimurium and Escherichia coli). The highest antibacterial activities of LME extract obtained using the HPMS method against Gram-positive bacteria (B. subtilis and S. aureus) were at 18:10 and 18.80 mm. The ultrasonication method showed a lower inhibition trend than the HPMS method, with MIC and MBC values of 250 mg/ml and 2-8 CFU/ml, respectively, in all Gram-negative and Gram-positive bacteria. The results showed that LME extract at a concentration of 250 mg/mL is bacteriostatic against Gram-positive and -negative bacteria.

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Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors

Cited by 202 publications

References 31 publications

Activity of meropenem, against Gram-positive bacteria

Activity of meropenem, against Gram-positive bacteria

Comparative activity of the penem antibiotic Sch 34343 against Gram-negative and Gram-positive bacteria with special reference to multiresistant strains

Antibacterial activities of β-glucan (laminaran) against gram-negative and gram-positive bacteria

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