Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study

Ignjatovic, A. Rakic; Nikolic, Katarina; Miljković, Branislava; Pokrajac, M.; Agbaba, Danica; Prostran, Milica

doi:10.1080/10826070903126963

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…The LOQ for both analytes was 20 ng/mL. In a few reports, the use of HPLC with UV detection for the assay of MOC and its metabolites in biofluids such as plasma (Misztal et al ., 2002; Rakic et al ., 2007; Plenis et al ., 2007; Ignjatovic et al ., 2009) and urine samples (Hoskins et al ., 2001b) was also reported. In these methods, the chromatographic separations were performed with C 6 (Hoskins et al ., 2001b) C 8 (Misztal et al ., 2002) and C 18 (Rakic et al ., 2007; Plenis et al ., 2007) analytical columns, respectively.…”

Section: Chromatographic Methodsmentioning

confidence: 99%

Modern chromatographic and electrophoretic measurements of antidepressants and their metabolites in biofluids

Plenis

Bączek

2010

Biomedical Chromatography

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Depression is one of the most frequently occurring psychiatric conditions affecting the economic and social functioning of people all over the world. There are a few classes of drugs commonly used to treat patients with depression disorders. Therapeutic drug monitoring of antidepressants provides the possibility to reduce side effects and optimize the treatment of patients with depression. Hence, there is a need to develop reliable analytical methods for the determination of these agents in biological fluids. Moreover, an important part of understanding the mechanisms of action of these medicines is also associated with the recognition of the metabolites' function because of their potential influence on therapeutic benefits and/or adverse effects. Some of them possess the same primary activity as their parent compounds and may contribute to the therapeutic efficacy whereas the biochemical actions of other metabolites may be different from that of the parent drug. In this review, several validated high-performance liquid chromatographic, gas chromatographic and capillary electrophoretic methods for quantification of antidepressants and their metabolites in biofluids are compared. In addition, the review covers areas such as mechanism of actions, structure-activity relationships and metabolism of the cited antidepressants.

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Section: Chromatographic Methodsmentioning

confidence: 99%

Modern chromatographic and electrophoretic measurements of antidepressants and their metabolites in biofluids

Plenis

Bączek

2010

Biomedical Chromatography

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An Overview of Analytical Methods for the Determination of Monoamine Oxidase Inhibitors in Pharmaceutical Formulations and Biological Fluids

Saka

2016

Critical Reviews in Analytical Chemistry

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Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed. MAOIs elevate the levels of norepinephrine, serotonin, and dopamine by inhibiting an enzyme called monoamine oxidase. They are also used in the treatment of Parkinson's disease, tuberculosis, and several other disorders. Therefore, it is very important to develop efficient analytical methods for monitoring and management. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. In this article, analyses of MAOIs in pharmaceutical formulations and biological fluids were reviewed from 2000 to the present, including all types of chromatographic, spectrophotometric, electrophoretic, and voltammetric techniques, focusing on isoniazid, tranylcypromine, moclobemide, rasagiline, and selegiline.

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Determination of Moclobemide and its Metabolites in Human Plasma by SPE-HPLC-UV: Evaluation of Critical Experimental Conditions and QSRR Study

Cited by 2 publications

References 17 publications

Modern chromatographic and electrophoretic measurements of antidepressants and their metabolites in biofluids

Modern chromatographic and electrophoretic measurements of antidepressants and their metabolites in biofluids

An Overview of Analytical Methods for the Determination of Monoamine Oxidase Inhibitors in Pharmaceutical Formulations and Biological Fluids

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