Determination of mode of interactions between novel drugs and calf thymus DNA by using quartz crystal resonator

Experimental and DFT Studies on the DNA-binding Properties of Ruthenium(II) Complexes [Ru(phen)2L]2+(L = o-MOP, o-MP, o-CP and o-NP)

“…The lowest-energy absorption bands ascribed to the MLCT transitions for (1), (2), (3) and (4) temperature, with the maximum at 589, 588 and 589, respectively, and only a very weak fluorescence was observed for complex (4) under the same conditions (the maximum is at 588 nm). The ligand 2-(2-methoxyphenyl)imidazo [4,5-f] [1,10] phenanthroline (o-MOP) was prepared by the method similar to that in [38], but with some modification.…”

“…A solution of phenanthraquinone (0.26 g, 1.2 mmol), o-anisaldehyde (0.24 g, 1.8 mmol) and NH 4 OAc(1.9 g, 25 mmol) in 10 cm 3 [Ru(phen) 2 (o-MOP)] 2+ (1) [Ru(phen) 2 (o-MOP)] 2+ was synthesized by the method described in [39] with some modification. [Ru-(phen) 2 Cl 2 ] AE 2H 2 O (0.09 g, 0.17 mmol) and (1a)(0.058 g, 0.17 mmol) were added to 10 cm 3 of ethylene glycol.…”

“…For decades, much attention has been focused on the interaction of octahedral Ru(II) complexes with DNA owing to their potential utility as DNA probes, molecular light switches and chemotherapy drugs for tumors [1][2][3][4][5][6][7][8]. In general, Ru(II) complexes can bind to DNA in three non-covalent modes: intercalation, groove and electrostatic bindings.…”

“…In this paper, a series of Ru(II) complexes with electron-donor or electron-acceptor substituents in the intercalative ligands, [Ru(phen) 2 (o-MOP)] 2+ (1), [Ru(phen) 2 (o-MP)] 2+ (2), [Ru(phen) 2 (o-CP)] 2+ (3) and [Ru(phen) 2 (o-NP)] 2+ (4) (Scheme 1), were synthesized and characterized. The spectroscopic and viscosity experiments were utilized to study the DNA-binding properties of these complexes, and the DFT calculations were also applied to further discuss the trend in the DNA-binding affinities.…”

A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature: applications of acoustic physics to the analysis of biomolecular interactions

“…Both Pope et al (2001) and Yau et al (2002) compared groove binders, namely Berenil and Hoechst 3342, respectively, to other cancer drugs using the QCM technique. Tombelli et al (2005b) used biotinylated probes to detect point mutations in the TP53 gene, which is mutated in most types of human cancers.…”