Determination of N-acetyl retigabine in dog plasma by LC/MS/MS following off-line μElution 96-well solid phase extraction

Bu, Wei; Nguyen, Minh Tien; Xu, Christine; Lin, Chin‐Chung; Yeh, Li‐Tain; Borges, Virginia

doi:10.1016/j.jchromb.2007.02.019

Cited by 16 publications

(6 citation statements)

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“…Just a few analytical methods are available for the TDM of EZG; most of them are based on liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) [34][35][36][37]. One of these methods [34] was applied to evaluate gender differences in EZG pharmacokinetics.…”

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

“…The column-switching pretreatment also makes this method rather complicated to set up and equipment-intensive. [34], (b) [35], and (c) [36].…”

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

“…The third method [36] deals with the determination of the N-acetyl metabolite by LC-APCI-MS/MS(QqQ) after pretreatment of 200 µL of plasma by micro-solid phase extraction (µSPE) in 96-well plates with a hydrophilic-lipophilic balance (HLB) sorbent; washing was carried out with two different ammonium acetate/acetonitrile/isopropyl alcohol mixtures, followed by elution with 1.2 mL of acetonitrile/isopropyl alcohol (40/60, v/v). To avoid the possible back-conversion of N-acetyl-EZG glucuronide to the parent N-acetyl-EZG, all materials and reagents for the dilution and µSPE procedures were refrigerated in ice; moreover, the glucuronide was eliminated from the sample by the washing step of the SPE procedure.…”

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

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Ion-Channel Antiepileptic Drugs: An Analytical Perspective on the Therapeutic Drug Monitoring (TDM) of Ezogabine, Lacosamide, and Zonisamide

et al. 2021

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The term seizures includes a wide array of different disorders with variable etiology, which currently represent one of the most important classes of neurological illnesses. As a consequence, many different antiepileptic drugs (AEDs) are currently available, exploiting different activity mechanisms and providing different levels of performance in terms of selectivity, safety, and efficacy. AEDs are currently among the psychoactive drugs most frequently involved in therapeutic drug monitoring (TDM) practices. Thus, the plasma levels of AEDs and their metabolites are monitored and correlated to administered doses, therapeutic efficacy, side effects, and toxic effects. As for any analytical endeavour, the quality of plasma concentration data is only as good as the analytical method allows. In this review, the main techniques and methods are described, suitable for the TDM of three AEDs belonging to the class of ion channel agents: ezogabine (or retigabine), lacosamide, and zonisamide. In addition to this analytical overview, data are provided, pertaining to two of the most important use cases for the TDM of antiepileptics: drug–drug interactions and neuroprotection activity studies. This review contains 146 references.

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Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

“…The column-switching pretreatment also makes this method rather complicated to set up and equipment-intensive. [34], (b) [35], and (c) [36].…”

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

See 2 more Smart Citations

Ion-Channel Antiepileptic Drugs: An Analytical Perspective on the Therapeutic Drug Monitoring (TDM) of Ezogabine, Lacosamide, and Zonisamide

et al. 2021

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“…These steps are not only timeconsuming but also cause experiment errors. microElution solid phase extraction (Elution SPE) has the unique design to allow the loading of 10-750 L of sample and eluting of ultra-low elution solvent, which is 25 L [17][18][19][20][21]. These properties help to avoid using large amount of sample, eliminate the evaporation and reconstruction step, hence increasing the sample throughput.…”

Section: Introductionmentioning

confidence: 99%

Evaluating misoprostol content in pregnant women with hourly oral administration during labor induction by microElution solid phase extraction combined with liquid chromatography tandem mass spectrometry

Hung

Cheng

Chan

et al. 2015

Journal of Chromatography B

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Current literature in mass spectrometry

2008

J. Mass Spectrom.

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P, Sanz L. Snake venomics. Strategy and applications. J Mass Spectrom 2007; 42: 1405. He MY, Chen H. Current mass spectrometry of synthetic polymer. Curr Org Chem 2007; 11: 909. Helmke SM, Duncan MW. Measurement of the NO metabolites, nitrite and nitrate, in human biological fluids by GC-MS. J Chromatogr B 2007; 851: 83. Herrmann AM, Ritz K, Nunan N, Clode PL, Pett-Ridge J, Kilburn MR, Murphy DV, O'Donnell AG, Stockdale EA. Nano-scale secondary ion mass spectrometry -A new analytical tool in biogeochemistry and soil ecology: A review article. Soil Biol Biochem 2007; 39: 1835. Luque-Garcia JL, Neubert TA. Sample preparation for serum/plasma profiling and biomarker identification by mass spectrometry. J Chromatogr A 2007; 1153: 259. Nelson BC. The expanding role of mass spectrometry in folate research. Curr Anal Chem 2007; 3: 219. Portier S, Bremier S, Walker CT. Secondary ion mass spectrometry of irradiated nuclear fuel and cladding: An overview. Int J Mass Spectrom 2007; 263: 113. Vogl J. Characterization of reference materials by isotope dilution mass spectrometry. J Anal Atom Spectrom 2007; 22: 475. Wiechert W, Schweissgut O, Takanaga H, Frommer WB. Fluxomics: Mass spectrometry versus quantitative imaging. Curr Opin Plant Biol 2007; 10: 323. Williamson LN, Bartlett MG. Quantitative liquid chromatography/time-offlight mass spectrometry. Biomed Chromatogr 2007; 21: 567. Wyttenbach T, Bowers MT. Intermolecular interactions in biomolecular systems examined by mass spectrometry. Annu Rev Phys Chem 2007; 58: 511. 2 INSTRUMENTAL TECHNIQUES & METHODS Alvarez PA, Ramaswamy HS, Ismail AA. Effect of high-pressure treatment on the electrospray ionization mass spectrometry (ESI-MS) profiles of whey proteins. Int Dairy J 2007; 17: 881. Andreev VP, Li LY, Cao L, Gu Y, Rejtar T, Wu SL, Karger BL. A new algorithm using cross-assignment for label-free quantitation with LC-LTQ-FT MS. J Proteome Res 2007; 6: 2186. Bereman MS, Muddiman DC. Detection of attomole amounts of analyte by desorption electrospray ionization mass spectrometry (DESI-MS) determined using fluorescence spectroscopy. J Am Soc Mass Spectrom 2007; 18: 1093. Borges CR. Concept for facilitating analyst-mediated interpretation of qualitative chromatographic-mass spectral data: An alternative to manual examination of extracted ion chromatograms. Anal Chem 2007; 79: 4805. Carreira RJ, Cordeiro FM, Moro AJ, Rivas MG, Rial-Otero R, Gaspar EM, Moura I, Capelo JL. New findings for in-gel digestion accelerated by high-intensity focused ultrasound for protein identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Chromatogr A 2007; 1153: 291. Chambers E, Wagrowski-Diehl DM, Lu ZL, Mazzeo JR. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J Chromatogr B 2007; 852: 22. Charvat A, Abel B. How to make big molecules fly out of liquid water: Applications, features and physics of laser assisted liquid phase dispersion mass spectrometry. Phys Chem Chem Phys 2007; 9: 3335. Codrea MC, Jimenez CR, Heri...

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Determination of N-acetyl retigabine in dog plasma by LC/MS/MS following off-line μElution 96-well solid phase extraction

Cited by 16 publications

References 6 publications

Ion-Channel Antiepileptic Drugs: An Analytical Perspective on the Therapeutic Drug Monitoring (TDM) of Ezogabine, Lacosamide, and Zonisamide

Ion-Channel Antiepileptic Drugs: An Analytical Perspective on the Therapeutic Drug Monitoring (TDM) of Ezogabine, Lacosamide, and Zonisamide

Evaluating misoprostol content in pregnant women with hourly oral administration during labor induction by microElution solid phase extraction combined with liquid chromatography tandem mass spectrometry

Current literature in mass spectrometry

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