Determination of N-nitrosoproline and N-nitrososarcosine in malt and beer

InternationalN‐nitroso compounds check sample programme: Report on the performance in the second study dedicated to their determination in beer and malt

“…The statistical parameters are presented in table 5, which, for each N-nitrosamine present in each sample, lists the median, the mean, the standard deviation, Sen et al (1983) n.d. = not detected; n.a. = not analysed; n.r.…”

“…Each laboratory was requested to analyse each sample for NDMA, NPYR and NPRO against the standard solutions which had been provided, using their own method for NDMA and NPYR and, if possible, the method of Sen et al (1983) which was attached to the letter of instruction for NPRO.…”

“…(1983) Sen étal. (1983) Sen et al (1983) Other Other Sen et al (1983) Sen et al (1983)Sen et al (1983) n.d. = not detected; n.a. = not analysed; n.r.…”

“…Little has been achieved for the other two common contaminants of beer and malt, N-nitrosopyrrolidine (NPYR) and NPRO. For this latter compound in beer, however, some hope came from the data produced by the method of Sen et al (1983), but the number of results is insufficient to allow firm conclusions to be drawn. …”

Transnitrosation of non-mutagenic N-nitrosoproline forms mutagenic N-nitroso-N-methylurea

“…10,11 NP was formed in stomach [12][13][14] and detected in foods. 15,16 The presence of these compounds in urine is considered as an indicator of nitrosation exposure in vivo. 17 Transnitrosation, in which a nitroso group is transferred from nitrosamine to another amine, is a reaction characteristic of N-aryland N-alkyl-N-nitrosoureas, [18][19][20][21] and N-aryl-N-nitrosamines.…”