Determination of nanogram quantities of gold in biological tissues by nondestructive neutron activation analysis

Sprague, Stuart M.; Carrick, J. T.; Wilkinson, Bruce W.; G, Mayor

doi:10.1007/bf02521293

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Pharmacokinetic Study1

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2015

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“…In order to avoid these artifacts, only gold levels in blood and tissue were used for quantifying the compounds of interest. The analysis of only the nonabundant Au metal 69 for the calculation of the drug concentration in animal tissues and plasma during our in vivo pharmacokinetic analysis is further justied by the results obtained in Caki-1 cells for compound 5 demonstrating the co-localization of Ti and Au metals. Content of compound 3 and compound 5 in blood and tissues was calculated from their gold content and normalized to the extraction efficiency of gold in the respective tissues and blood.…”

Section: Pharmacokinetic Studymentioning

confidence: 84%