Determination of nasal mucociliary clearance time and nasal symptom in patients with Crimean‐Congo hemorrhagic fever

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is an important health problem in Turkey. Number of studies on symptoms of ear nose throat system and indicating whether or not the organs are affected in patients with CCHF is limited. The aim of the present study was to investigate whether CCHF infections caused any change in nasal physiology in adult patients or not by using saccharin transit time (STT) and nasal symptom scoring. Twenty subjects with laboratory-confirmed diagnosis of CCHF and 28 healthy control subjects were included in the present study. A saccharin test was used to evaluate nasal mucociliary clearance time (NMCT) and the nasal symptom scoring used in allergic rhinitis was modified and used to examine the symptoms of the patients. The average STT of CCHF and control groups were 472.70 ± 151.58 and 276.07 ± 89.65 sec, respectively. The difference between them was statistically significant (P = 0.00, P < 0.05). When those in CCHF group were classified according to timing of the test, STT average of those undergoing the test on the 1st-3rd days (n = 10) and 4th-6th (n = 10) days was 547.00 ± 154.37 and 398.40 ± 111.39 sec, respectively. The difference between them was statistically significant (P = 0.024; P < 0.05). The results of the present study showed that NMCT prolonged in adult patients with CCHF compared to those in the control group despite the fact that it was within normal limits. For these reasons, clinicians should follow-up CCHF patients more closely for respiratory tract diseases and sinonasal and middle ear infections. J. Med. Virol. 89:960-965, 2017. © 2016 Wiley Periodicals, Inc.

Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: a cross-sectional study

“…In 2017, Chinnapaiyan et al [27] reported that HIV infection suppressed tracheobronchial mucociliary clearance and predisposed patients to recurrent lung infections, pneumonia and chronic bronchitis. Similarly, Durmuş et al [28] found that the NMCT was prolonged in adult patients with Crimean-Congo haemorrhagic fever compared with healthy individuals in the control group.…”

Evaluation of Nasal Mucociliary Clearance Time in COVID-19 Patients

“…Durmus ¸et al 14 found that nasal MCC duration was longer in patients with a diagnosis of laboratory-confirmed CCHF than healthy individuals and that the difference between them was statistically significant. They reported that clinicians should follow CCHF patients more closely for respiratory tract diseases, sinonasal and tympanum infections.…”

“…In the literature, studies are showing the change of MCC duration in viral diseases such as Human Immunodeficiency Virus (HIV) and Crimean-congo hemorrhagic fever (CCHF). 14,17 Milgrim et al 17 reported that the duration of nasal MCC in HIV patients was longer than in nonHIV controls, and the difference between them was statistically significant. The authors stated that the prolonged nasal MCC duration correlated with nasal obstruction.…”

“…Both acquired and genetic impairment of MCC disrupt respiratory mechanisms and cause chronic infections of the nose, paranasal sinuses, and lower respiratory tracts. 14 It is known that viral infections cause a change in MCC by increasing mucus secretion, affecting normal ciliary movement, and causing airway epithelial damage. In the literature, studies are showing the change of MCC duration in viral diseases such as Human Immunodeficiency Virus (HIV) and Crimean-congo hemorrhagic fever (CCHF).…”

Investigating dizziness symptom in adult cases with Crimean-Congo hemorrhagic fever using various scales

“…Starting with epistaxis, CCHFV is known to cause various symptoms in terms of Ear Nose Throat (ENT) such as dizziness, hear loss, and nasal congestion. In the literature, we can reach concerning these symptoms; all symptoms except for the dizziness complaint in particular were seen to be evaluated with various previous studies [10][11][12].…”