Natural gas station is an important part of the whole natural gas pipeline transmission system, in which the pipeline vibration is a hidden danger that cannot be ignored for the safe operation of the station. In view of the severe vibration of the pipeline in a natural gas station of an enterprise, the vibration acceleration sensors are used to test the vibration of each measuring point under different working conditions, and then the three-dimensional finite element model of the pipeline is established by using numerical simulation software to study its structural characteristics and gas column characteristics. Through the analysis of field test results and simulation results, it is found that there are two main vibration frequencies in the pipeline: 116.75 Hz and 123.0 Hz. The former is caused by the resonance between the gas column frequency and the natural frequency in pipe B; The latter is due to the impact of the gas column force in pipe A on pipe B.