Determination of neomycin sulfate and impurities using high-performance anion-exchange chromatography with integrated pulsed amperometric detection

Hanko, Valoran P.; Rohrer, Jeffrey S.

doi:10.1016/j.jpba.2006.06.024

Cited by 30 publications

(13 citation statements)

References 14 publications

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“…Neomycin sulfate is a particular aminoglycoside antibiotic being the mixture of two stereoisomers as neomycin B (main product presented in Figure 3b) and neomycin C, less than 3.0% [29,30]. Acid hydrolysis of neomycin B yields neamine and neobiosamine B, and the hydrolysis of neomycin C leads to neamine and neobiosamine C [30].…”

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

“…Acid hydrolysis of neomycin B yields neamine and neobiosamine B, and the hydrolysis of neomycin C leads to neamine and neobiosamine C [30]. Neobiosamine B and C are composed of D-ribose and neosamine B and C, respectively [30]. To elucidate the neomycin behavior, UV-Vis spectrophotometry of 1.0 M H2SO4 solution containing 0.9 mM neomycin was performed.…”

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

“…Thus, the concentration of neomycin decreases causing the alteration of its spectrum, but in the same time the absorbance increases due to the appearance of new chemical species. According to literature data, the main decomposition compounds consist of neamine and neobiosamine [30]. The neomycin B electrochemical decomposition mechanism is proposed, as shown in Scheme 1.…”

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

“…According to literature data, the main decomposition compounds consist of neamine and neobiosamine [30]. The neomycin B electrochemical decomposition mechanism is proposed, as shown in Scheme 1.…”

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

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Inhibitory Properties of Neomycin Thin Film Formed on Carbon Steel in Sulfuric Acid Solution: Electrochemical and AFM Investigation

et al. 2017

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Abstract:Our study aims to implement a strategy to reduce the carbon steel corrosion rate in a sulfuric acid solution, using an expired drug with adsorption affinity on the metal surface. To investigate the corrosion protection efficiency of an environmental friendly inhibitor, namely neomycin sulfate (NMS), the electrochemical measurements were applied on carbon steel immersed in 1.0 M H 2 SO 4 solution with and without NMS. The protective layer that formed on the steel surface was studied by atomic force microscopy (AFM). The potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) showed that the presence of the neomycin sulfate in acid solution leads to the decrease in corrosion current density (i corr ) and the increase of polarization resistance (R p ). The mixed mechanism between physical and chemical adsorption of NMS molecules on the steel surface was proposed according to the Langmuir adsorption isotherm. AFM indicated that the NMS molecules contributed to a protective layer formation by their adsorption on the steel surface. The AFM parameters, such as root mean square roughness (R q ), average roughness (R a ), and maximum peak to valley height (R p−v ) revealed that in the presence of NMS a smoother surface of carbon steel was obtained, compared to the steel surface corroded in sulfuric acid blank solution.

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Section: Nms Adsorption Mechanismmentioning

confidence: 99%

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

Section: Nms Adsorption Mechanismmentioning

confidence: 99%

See 2 more Smart Citations

Inhibitory Properties of Neomycin Thin Film Formed on Carbon Steel in Sulfuric Acid Solution: Electrochemical and AFM Investigation

et al. 2017

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“…al., 2010). A variabilidade intra e inter-ensaios pode prejudicar a confiabilidade do método, e as impurezas de antibióticos podem produzir erros, comprometendo a precisão do método (HANKO & ROHRER, 2007). Entretanto, apesar da alta variabilidade, sendo os ensaios microbiológicos realizados com suas condições devidamente padronizadas e controladas, estes fornecerão adequada determinação da potência, além de apresentarem vantagens como a possibilidade da verificação da perda de atividade de um antibiótico (ABDELAZIZ et.…”

Section: Doseamento Microbiológico De Antibióticosunclassified

Doseamento microbiológico de neomicina e bacitracina - desenvolvimento e validação de método rápido em microplacas

Francisco¹

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Ion Chromatography Analysis of Aminoglycoside Antibiotics

Hanko

Rohrer

2012

Applications of Ion Chromatography for Pharmaceutical and Biological Products

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Determination of neomycin sulfate and impurities using high-performance anion-exchange chromatography with integrated pulsed amperometric detection

Cited by 30 publications

References 14 publications

Inhibitory Properties of Neomycin Thin Film Formed on Carbon Steel in Sulfuric Acid Solution: Electrochemical and AFM Investigation

Inhibitory Properties of Neomycin Thin Film Formed on Carbon Steel in Sulfuric Acid Solution: Electrochemical and AFM Investigation

Doseamento microbiológico de neomicina e bacitracina - desenvolvimento e validação de método rápido em microplacas

Ion Chromatography Analysis of Aminoglycoside Antibiotics

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