Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice

Alarifi, Saud; Ali, Daoud; Gurabi, Mohammed A Al; Alkahtani, Saad

doi:10.1080/02772248.2016.1175153

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…Oxidative stress is a metabolic dysfunction that results in cell damage, and can be triggered by multiple ECs, such as azoxystrobin, silver nanoparticles, and profenofos. [42][43][44][45] Excess ROS will damage the antioxidant capacity, cause mitochondria injury and genotoxicity and lead to cell apoptosis. 46,47 Mitochondria are the primary source of endogenous ROS, mitochondria dysfunction will lead to increased oxidative stress, which results in the production of lipid peroxidation, and MDA is one of the indicators of oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

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Curcumin alleviates bisphenol AF‐induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway

Liu

Wang

et al. 2023

Environmental Toxicology

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Bisphenol AF (BPAF), a BPA‐substitute, has been widely used in industrial compounds throughout the world. Several studies have shown that BPAF has endocrine interference and reproductive toxicity. However, the toxic effects of BPAF on pregnancy and placenta of goats are still unclear. Therefore, the objective of this study was to reveal the toxic effect of BPAF by using an in vitro culture model of caprine endometrial epithelial cells (EECs) and further attempted to alleviate the toxicity by curcumin pretreatment. The results showed that BPAF induces significant effects on EECs, including decreased cell viability and mitochondrial membrane potential (△ψm), elevating intracellular reactive oxygen species (ROS), promoting cell apoptosis through upregulating the expression of Bax, Cytochrome c, and downregulating the expression of Bcl‐2. Meanwhile, BPAF induced dysregulation of oxidative stress by increasing the levels of malondialdehyde (MDA) and glutathione peroxidase (GSH‐Px) but decreasing the activities of superoxide dismutase (SOD). However, curcumin pretreatment could significantly attenuate BPAF‐induced toxic effects in EECs. Further study revealed that BPAF treatment could activate mitogen‐activated protein kinase (MAPK) pathway and nuclear factor‐erythroid 2‐related factor 2 (Nrf2) expression, but curcumin pretreatment significantly inhibited the activation of MAPK signal pathway and Nrf2 expression induced by BPAF. Overall, this study indicated that curcumin could prevent BPAF‐induced EECs cytotoxicity, which provides a potential therapeutic strategy for female infertility associated with BPAF exposure.

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Section: Discussionmentioning

confidence: 99%

“…Oxidative stress is a metabolic dysfunction that results in cell damage, and can be triggered by multiple ECs, such as azoxystrobin, silver nanoparticles, and profenofos 42–45 . Excess ROS will damage the antioxidant capacity, cause mitochondria injury and genotoxicity and lead to cell apoptosis 46,47 .…”

Section: Discussionmentioning

confidence: 99%

Curcumin alleviates bisphenol AF‐induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway

Liu

Wang

et al. 2023

Environmental Toxicology

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“…The brain biochemistry and neurobehavior were evaluated after 35 days of weekly injection ( Figure 1 ). The concentrations of Ag-NPs and YO-NPs were selected based on the previously published studies described by Alarifi et al [ 25 ] and Song et al [ 23 ], respectively. This in vivo experimental study was approved by Jazan University, Jazan, Saudi Arabia, with the ethical number “REC-43/02/019.”…”

Section: Methodsmentioning

confidence: 99%

Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles

Abu-Taweel

Al-Mutary

Albetran

2022

Oxidative Medicine and Cellular Longevity

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Silver nanoparticles (Ag-NPs) have been used in medical, agricultural, and industrial purposes. Furthermore, NPs can cross the blood-brain barrier and encourage some effects on spatial learning and memory in organism. Here, we investigate the possible neurotoxicity of Ag-NPs with special emphasis on the neuroprotective impacts of yttrium-oxide nanoparticles (YO-NPs) in male mice. Male mice ( n = 24 ) were weekly intraperitoneally injected for 35 days as the following; groups I, II, III, and IV received tap water (control), Ag-NPs (40 mg/kg), YO-NPs (40 mg/kg), and Ag-NPs/YO-NPs (40 mg/kg each), respectively. After that, animals were tested in shuttle box, Morris water-maze, and T-maze devices to evaluate the spatial learning and memory competence. Neurotransmitters and oxidative indices in the forebrain were estimated. According to behavioral studies, the male animals from the Ag-NP group presented worse memory than those in the control group. The biochemical changes after Ag-NP exposure were observed through increasing TBARS levels and decline in oxidative biomarkers (SOD, CAT, GST, and GSH) and neurotransmitters (DOP, SER, and AChE) in the forebrain of male mice compared to untreated animals. Interestingly, the animals treated with mixed doses of Ag-NPs and YO-NPs displayed improvements in behavioral tests, oxidative parameters, and neurotransmitters compared to males treated with Ag-NPs alone. In conclusion, the abnormal behavior related to learning and memory in male mice induced by Ag-NPs was significantly alleviated by YO-NPs. Specifically, the coinjection of YO-NPs with Ag-NPs moderates the disruption in neurotransmitters, oxidative indices of mice brains, which reflects on their cognitive behaviors.

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Protective effects of Asparagus officinalis (asparagus) against lead toxicity in mice

Alyami

Almeer

Alyami

2022

Environ Sci Pollut Res

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Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice

Cited by 10 publications

References 15 publications

Curcumin alleviates bisphenol AF‐induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway

Curcumin alleviates bisphenol AF‐induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway

Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles

Protective effects of Asparagus officinalis (asparagus) against lead toxicity in mice

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