Determination of nine pharmaceutical active compounds in surface waters from Paraopeba River Basin in Brazil by LTPE-HPLC-ESI-MS/MS

Barros, André Luis Corrêa de; Schmidt, Felix F.; Aquino, Sérgio Francisco de; Afonso, Robson José de Cássia Franco

doi:10.1007/s11356-018-2123-y

Cited by 33 publications

(7 citation statements)

References 53 publications

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“…For example, some changes were observed during the separation between propranolol enantiomers when HSA concentration increases. 30 So, preliminary assays were performed at different voltages (ranging from 12 to 20 kV), temperatures (15-21 C), HSAs (10-20 μM), NDs (0%-0.25%, w/v), and pH values (8)(9)(10)(11). Related to the pH, the better results were obtained at pH 9.5.…”

Section: Optimization Of Ekc Experimental Conditions For the Chiral S...mentioning

confidence: 99%

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo‐stationary phase in river water

Lanaro,

Sombra,

Altamirano

et al. 2024

Chirality

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Propranolol is currently considered as an emerging contaminant in water bodies. In this study, R‐ and S‐propranolol were determined in river samples by electrokinetic chromatography (EKC) using nanodiamonds (NDs) and human serum albumin (HSA) as a pseudo‐stationary phase in order to achieve enantioseparation. Previously, river samples were preconcentrated using a column filled with Amberlite® IR‐120 and Dowex® 50WX8 resins. The setting up of influential factors such as temperature, voltage, pH, and HSA and NDs concentration is accurately described along this manuscript. A multivariate study and optimization was carried out to obtain the enantioseparation of propranolol (Rs = 2.91), which was reached under the following experimental conditions: voltage of 16 kV, temperature of 16°C, phosphate buffer pH 9.5, NDs of 0.20%, and HSA of 15 μmol l−1. The recoveries of analytes under optimal conditions were higher than 98%. The limits of detection were 0.85 μg l−1 for R‐ and S‐propranolol. The method was applied to real samples, and the obtained results in three different water sources studied were 1.02, 0.59, and 0.30 μg l−1 for the R‐enantiomer and 0.99, 0.54, and 0.28 μg l−1 for the S‐enantiomer. The accuracy of the proposed methodology (including bias and precision) has allowed us to propose it as a successful tool for the control of water quality.

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Section: Optimization Of Ekc Experimental Conditions For the Chiral S...mentioning

confidence: 99%

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo‐stationary phase in river water

Lanaro,

Sombra,

Altamirano

et al. 2024

Chirality

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“…The second aspect concerns the matrix, since most of the studies were directed at the determination of LNZ in biological fluids or pharmaceutical preparations. Only recently did de Barros and coworkers [ 74 ] report a method for the simultaneous determination of LNZ among other drugs in the surface water of a Brazilian river, which is therefore useful for the determination in environmental field. To our knowledge, this paper is the only one reporting the determination of LNZ in natural waters.…”

Section: Perspectives Challenges and Conclusionmentioning

confidence: 99%

Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects

et al. 2021

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This review covers the main aspects concerning the chemistry, the biological activity and the analytical determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clinical use over the past 50 years. They are characterized by a chemical structure including the oxazolidone ring with the S configuration of substituent at C5, the acylaminomethyl group linked to C5 and the N-aryl substituent. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Here, the main features of oxazolidinone antibiotics licensed or under development, such as Linezolid, Sutezolid, Eperezolid, Radezolid, Contezolid, Posizolid, Tedizolid, Delpazolid and TBI-223, are discussed. As they are protein synthesis inhibitors active against a wide spectrum of multidrug-resistant Gram-positive bacteria, their biological activity is carefully analyzed, together with the drug delivery systems recently developed to overcome the poor oxazolidinone water solubility. Finally, the most employed analytical techniques for oxazolidinone determination in different matrices, such as biological fluids, tissues, drugs and natural waters, are reviewed. Most are based on HPLC (High Performance Liquid Chromatography) coupled with UV-Vis or mass spectrometer detectors, but, to a lesser extent are also based on spectrofluorimetry or voltammetry.

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“…DCF has low biodegradability (Ahmed and Hameed 2018) and is considered a high-risk substance, included in the first Water Framework Directive list (Decision (EU) 2015/495, 2015, Directive 2013/39/EU 2013). Different concentrations of these drugs in water sources have already been reported in several countries, such as Brazil (Pereira et al 2016;de Barros et al 2018;Chaves et al 2020), Mexico (Rivera-Jaimes et al 2018, France (Andreozzi et al 2003), and Malaysia (Omar et al 2019). Usually, these concentrations are in the ng L −1 or μg L −1 scale (Chia et al 2021); however, they have already been found the values of 0.15 mg L −1 for SMX (Caldas et al 2018) and 0.19 mg L −1 for DCF (Campanha et al 2014).…”

Section: Introductionmentioning

confidence: 96%

Emerging contaminants in the aquatic environment: phytoplankton structure in the presence of sulfamethoxazole and diclofenac

Duarte

Ribeiro

Carvalho

et al. 2023

Environ Sci Pollut Res

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Chemicals from anthropogenic activities such as domestic sewage, pesticide leaching, and improper chemical disposal have caused groundwater contamination. The presence of these emerging contaminants in the aquatic environment can change water quality and biota composition. Thus, this study investigates the effect of two emerging contaminants, anti-inflammatory drug diclofenac (DCF) and antibiotic sulfamethoxazole (SMX), on the aquatic environment, evaluating the phytoplankton community structure. A microcosm experiment was conducted with 16 sampling units, each one with 500 mL of water sample containing phytoplankton exposed to these drugs at different concentrations (0.1, 0.5, and 1.0 mg L −1 ). The experiment lasted 15 days, and samples were collected on days 0, 3, 5, 7, and 14 to evaluate the phytoplankton community, the concentrations of the drugs, and the nutrients in the samples. Six phytoplankton groups were identified, and diatoms and green algae were the most diverse and abundant groups. For the entire community, we identified differences between the days of the experiment, varying in the diversity and density of organisms, but not between the concentrations of the two drugs. Evaluating the groups separately, we identified differences in the abundance of cyanobacteria for the treatment with diclofenac and desmids for the treatment with sulfamethoxazole. We demonstrated that the presence of pharmaceuticals in freshwater ecosystems can somehow affect the phytoplankton community, especially the diversity and abundance of cyanobacteria and desmids. Therefore, our study indicates the importance of evaluating the presence of pharmaceuticals in freshwater ecosystems and their influence on aquatic organisms, as well as pharmaceuticals may be changing the structure of the aquatic environment.

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Determination of nine pharmaceutical active compounds in surface waters from Paraopeba River Basin in Brazil by LTPE-HPLC-ESI-MS/MS

Cited by 33 publications

References 53 publications

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo‐stationary phase in river water

Chiral separation of propranolol by electrokinetic chromatography using nanodiamonds and human serum albumin as a pseudo‐stationary phase in river water

Oxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects

Emerging contaminants in the aquatic environment: phytoplankton structure in the presence of sulfamethoxazole and diclofenac

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