Determination of nitration kinetics of p-Nitrotoluene with a homogeneously continuous microflow

Continuous flow nitration of 3-[2-chloro-4-(trifluoromethyl) phenoxy] benzoic acid and its chemical kinetics within droplet-based microreactors

“…For the nitration of 2-ethylhexanol with the mixed acid in a microreactor, Li et al (Li et al, 2017) further raised the reaction temperature to room temperature which was significant compared to the commonly applied temperature range of 263 K to 283 K in batch reactors. In addition, the homogeneous nitration kinetics of aromatic compounds were well investigated by Luo's group (Cui et al, 2022, Song et al, 2022a, 2022b) using a continuous flow microreactor, where each experimental data could be obtained in a few seconds due to the accurate temperature control.…”

Study on Continuous Flow Nitration of Naphthalene

“…Although nitric acid and sulfuric acid may be diffused into the organic phase in opposite directions through water, the solubility is negligible because it is quite small, while the decoupling of mass transfer and reaction speed is very tough. Because of the relatively good mass transfer effect of microreactors, heterogeneous nitration can be regarded as a pseudohomogeneous reaction occurring in the aqueous phase, and the reaction order follows the second-order reaction widely accepted in the nitration of aromatic compounds. , …”

“…Because of the relatively good mass transfer effect of microreactors, heterogeneous nitration can be regarded as a pseudohomogeneous reaction occurring in the aqueous phase, and the reaction order follows the second-order reaction widely accepted in the nitration of aromatic compounds. 31,32 The reaction rate of nitration can be denoted by eq 8: (8) k app denotes the apparent kinetic constant. C Nap and C HNOd 3 t represent the concentration of naphthalene and nitric acid during the reaction, respectively.…”

A novel observation platform for determining the micro-dispersion performance in practical reaction systems

“…[1][2][3][4] This technology also provides a powerful tool especially for the development of high-temperature and high-pressure reactions, highly exothermic reactions, and reactions involving hazardous materials. [5][6][7][8] Due to the transformation from macro to micro scale, the working mechanisms in microdevices differ significantly from traditional large reactors. Therefore, considerable efforts have been devoted to explore the fundamental principles of microreaction technology in recent years, such as the general rules of droplet/bubble formation processes, hydrodynamics of droplet/bubble swarms, and evolution of flow regimes.…”