Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry

Gadaj, Anna; Lullo, Valentina di; Cantwell, Helen; McCormack, Martin; Furey, Ambrose; Danaher, Martin

doi:10.1016/j.jchromb.2014.04.024

Cited by 25 publications

(17 citation statements)

References 33 publications

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“…A low residue method validation was reported previously (Gadaj et al 2014). Briefly, depending on the analyte.…”

Section: Methods Validationmentioning

confidence: 99%

“…Dimetridazole (high residue method) were used in this study. A low residue method was reported previously (Gadaj et al 2014), whereas an additional high residue procedure was developed and validated for the current study since the concentration of nitroimidazole residues detected in treated shrimp tissues at certain time points (day 0 (MNZ), day 0 -8 (DMZ) and day 0 -4 (RNZ)) exceeded the range of the initial method used.…”

Section: Materials and Reagentsmentioning

confidence: 99%

“…A high mixed calibration range was prepared at concentrations of 0.2 (std 1), 0.5 (std 2), 1 (std 3), 2.5 (std 4), 5 (std 5), 10 (std 6), 25 (std 7), 50 (std 8) and 100 (std 9) µg mL -1 in MeOH, by serial dilution of the stock solutions. The preparation of standards for a low calibration range is described elsewhere (Gadaj et al 2014). An intermediate and a working internal standard mix solution were prepared at 100 and 5 µg mL…”

Section: Materials and Reagentsmentioning

confidence: 99%

“…Following the addition of 1 mL of H 2 O, samples were vortexed for 60 s. Extracts were filtered through 0.2 µm PTFE 13 mm Millex-FG syringe filters (Millipore, Cork, Ireland) and 2 µL were injected onto the UHPLC-MS/MS system. The UHPLC-MS/MS conditions are described in detail elsewhere (Gadaj et al 2014). …”

Section: Analysis Of Nitroimidazole Residues In Test Samplesmentioning

confidence: 99%

“…Samples were vortexed for 60 s and 1 mL of the extracts were transferred to clean empty 5 mL glass tubes. The preparation of extracted matrix calibrants and controls checks for the low residue method is described elsewhere (Gadaj et al 2014). …”

Section: Preparation Of Extracted Matrix Calibrants and Recovery Contmentioning

confidence: 99%

See 4 more Smart Citations

Determination of the persistence of dimetridazole, metronidazole and ronidazole residues in black tiger shrimp (Penaeus monodon) tissue and their stability during cooking

Gadaj

Cooper

Karoonuthaisiri

et al. 2014

Food Additives & Contaminants: Part A

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“…A low residue method validation was reported previously (Gadaj et al 2014). Briefly, depending on the analyte.…”

Section: Methods Validationmentioning

confidence: 99%

Section: Materials and Reagentsmentioning

confidence: 99%

Section: Materials and Reagentsmentioning

confidence: 99%

Section: Analysis Of Nitroimidazole Residues In Test Samplesmentioning

confidence: 99%

Section: Preparation Of Extracted Matrix Calibrants and Recovery Contmentioning

confidence: 99%

See 3 more Smart Citations

Determination of the persistence of dimetridazole, metronidazole and ronidazole residues in black tiger shrimp (Penaeus monodon) tissue and their stability during cooking

Gadaj

Cooper

Karoonuthaisiri

et al. 2014

Food Additives & Contaminants: Part A

Self Cite

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Development and validation of a liquid chromatography with tandem mass spectrometry method for the determination of nitroimidazole residues in beeswax

Mitrowska

Antczak

2017

J. Sep. Sci.

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In this study, a new method for the determination of 12 nitroimidazoles and their hydroxymetabolites (metronidazole, hydroxymetronidazole, dimetridazole, ronidazole, hydroxydimetridazole, ipronidazole, hydroxyipronidazole, carnidazole, ornidazole, secnidazole, ternidazole, tinidazole) in beeswax has been developed and validated. The optimized sample preparation procedure included melting and dilution of beeswax in a mixture of n-hexane and isopropanol followed by extraction with 2% acetic acid. The extracts were purified on strong cation exchange based solid-phase extraction cartridges and evaporated in a vacuum system with vortex motion. The separation and detection of the nitroimidazoles in the beeswax extracts were achieved within 12 min by liquid chromatography tandem mass spectrometry using a pentafluorophenyl analytical column and applying a gradient elution with acetonitrile and 0.01% acetic acid as mobile phases. The method performance characteristics were evaluated at three concentration levels (1, 2, and 5 μg/kg) and the method was found to be suitable for determination of all tested nitroimidazoles. The limits of detection and quantification were 0.2-0.5 and 0.5-1 μg/kg, respectively. The recoveries varied from 71.2 to 104.9% while the relative standard deviations were less than 13.8% under the intermediate precision conditions.

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The combined determinations of multiple veterinary drugs in animal foods by high‐performance liquid chromatography‐diode array detection and their application in drug residue investigation

Liu,

Kong,

et al. 2024

Separation Science Plus

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The application of veterinary drugs has brought great economic benefits, but its unreasonable application has also caused a series of safety problems. The study aimed to establish methods that will provide accurate quantitative information for the monitoring of veterinary drug residues in animal‐derived foods. Selecting nine veterinary drugs in four categories, the study combined quick, easy, cheap, effective, rugged, and safe technology with high‐performance liquid chromatography (HPLC) to detect multiple veterinary drugs in animal foods simultaneously. The study established two rapid, efficient, and accurate HPLC‐diode array detection methods to achieve the simultaneous detection of nitroimidazoles and β‐adrenergic agonists, and the simultaneous detection of benzimidazoles and diethylstilbestrol. The limit of detection of the former was 1.36–2.05 μg/kg and the latter 0.42–0.72 μg/kg. Then the two methods were used to detect veterinary drug residues in 297 animal foods from 10 categories to investigate the drug residues. For the seven banned drugs, the detection rates ranged from 1.35% to 7.41%. And for the two restricted drugs, the over‐standard rates were 4.38% and 0.00%.

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Determination of nitroimidazole residues in aquaculture tissue using ultra high performance liquid chromatography coupled to tandem mass spectrometry

Cited by 25 publications

References 33 publications

Determination of the persistence of dimetridazole, metronidazole and ronidazole residues in black tiger shrimp (Penaeus monodon) tissue and their stability during cooking

Determination of the persistence of dimetridazole, metronidazole and ronidazole residues in black tiger shrimp (Penaeus monodon) tissue and their stability during cooking

Development and validation of a liquid chromatography with tandem mass spectrometry method for the determination of nitroimidazole residues in beeswax

The combined determinations of multiple veterinary drugs in animal foods by high‐performance liquid chromatography‐diode array detection and their application in drug residue investigation

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