Determination of Noise Components in Laser Correlation Spectroscopic Devices for Signal-to-Noise Ratio Estimation

Nepomnyashchaya, Elina; Velichko, Elena; Котов, О. И.

doi:10.1109/eexpolytech.2019.8906887

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…The circuit elements selected according to calculated requirements provided signal-to-noise ratio (SNR) of more than 10 for all detected signals [28]. SNR was calculated using [34][35][36]. The choice of the photomultiplier is discussed in detail in our recent article [36] and is explained by main features of the spectrometer, which are very weak scattered radiation signals (~−70 dBm), low-frequency nature of the received signals (<100 kHz), and low background illumination due to the use of optical fibers in the optical scheme.…”

Section: Dynamic Light Scattering Spectrometermentioning

confidence: 99%

Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering

Velichko

Makarov

Nepomnyashchaya

2020

Biology

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Determination of the concentration and size of the circulating immune complexes in the blood is an essential part of diagnostics of immune diseases. In this work, we suggest using the dynamic light scattering method to determine the sizes of circulating immune complexes in blood serum. By the dynamic light scattering spectrometer, we found that for healthy and sick donors, the size and concentration of circulating immune complexes differed significantly. The dynamics of formation of these complexes were also examined in this work. It was shown that the formation of immune complexes in the blood of healthy donors is faster than the same reactions in the blood serum of donors with diseases. The results can be used in the diagnostics of the immune status and detection of chronic inflammation. We can recommend the dynamic light scattering method for implementation in biomedical diagnostics.

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