Determination of nor-nitrogen mustard hydrochloride using gas chromatography with flame ionization detection

Thulin, Hans

doi:10.1016/s0021-9673(01)88680-5

Cited by 1 publication

(1 citation statement)

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“…No chemical method for the analysis of nor-nitrogen mustard in ambient air or on surfaces was available, therefore appropriate assays were developed for this study (Thulin, 1991(Thulin, , 1993. This is the first time, to our knowledge, that both air and surface contamination has been monitored in combination with measurements of cytological and mutational changes in humans exposed to nor-nitrogen mustard or any other alkylating agent.…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure To Nor-Nitrogen Mustard: Chemical and Biological Monitoring

Thulin¹,

Sundberg²,

Hansson³

et al. 1995

Toxicol Ind Health

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Nor-nitrogen mustard is an alkylating agent used in kilogram quantities in the production of various cytostatics. It has been shown to be mutagenic in vitro, and therefore must be regarded as a health hazard. We have studied the environment and blood of a small group of individuals working with nor-nitrogen mustard. New chemical methods for measuring surface contamination were used to make comparisons with ambient air levels of nor-nitrogen mustard. Surprisingly high levels of surface contamination were found even after decontamination, which has led to new decontamination routines and the establishment of wipe test limits of 0.5 microgram nor-nitrogen mustard/dm2. The wipe test has proved effective in following the day-to-day routine handling of nor-nitrogen mustard. Blood samples were taken before, during, and after production runs and analyzed for the frequency of chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and somatic (HPRT) mutations. No significant differences in chromosome aberrations, SCEs, or somatic mutations were found in the peripheral blood from production workers before, during, or after handling of nor-nitrogen mustard. Nor was any difference found between the production workers and a local control group. However, the local controls' chromosome and HPRT frequencies appeared to be somewhat high, demonstrating the problems involved in these types of studies, in which the group sizes are small.

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Section: Introductionmentioning

confidence: 99%