Determination of Normal Hepatic Elasticity by Using Real-time Shear-wave Elastography

Suh, Chong Hyun; Kim, So Yeon; Kim, Kyung Won; Lim, Young‐Suk; Lee, So Jung; Lee, Moon-Gyu; Lee, Jung Bok; Lee, Sung‐Gyu; Yu, Eunsil

doi:10.1148/radiol.14131251

Cited by 78 publications

(66 citation statements)

References 32 publications

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“…In our experiment, SWE showed an excellent methodology stability and reliability. This conclusion was consistent with the findings in previous studies (31,32).…”

Section: Discussionsupporting

confidence: 94%

Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of Shear Wave Elastography with Serologic Tests

et al. 2018

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Background: Non-invasive evaluation of hepatic fibrosis, especially serum biomarkers and ultrasound elastography, has vigorously developed during the past decades. Objectives: The purpose of this study was to evaluate the diagnostic performance of the latest generation of ultrasound elastography-two-dimensional real-time shear wave elastography (SWE) in accessing liver fibrosis progression in comparison with serologic tests in a rat model. Materials and Methods: Liver fibrosis was induced in 108 rats (control group: 18 rats, experiment group: 90 rats) by intraperitoneal injection of thioacetamide (300mg/kg, twice a week for 12 weeks). SWE examination was done by two operators. Hyaluronic acid (HA), aspartate aminotransferase (AST) to platelet (PLT) ratio index (APRI), AST to alanine aminotransferase (ALT) ratio (AAR) were used for serology tests. Histological fibrosis stages (F0-F4) according to the Scheuer scoring system were referred as the gold standard. Diagnostic performance of elastography and serology methods were determined by the areas under receiver operating characteristic curve (AUROC). Results:Liver stiffness values increased with the progression of hepatic fibrosis. Liver stiffness assessed by SWE exhibited a strong positive correlation with histological fibrosis stages (r = 0.849, P < 0.001). SWE showed a better diagnostic performance than the selected serological biomarkers HA, APRI, and AAR (AUROC for SWE, HA, APRI, and AAR were 0.933, 0.707, 0.714, and 0.691 in diagnosing

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“…In our experiment, SWE showed an excellent methodology stability and reliability. This conclusion was consistent with the findings in previous studies (31,32).…”

Section: Discussionsupporting

confidence: 94%

Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of Shear Wave Elastography with Serologic Tests

et al. 2018

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“…Con respecto a los 33 sujetos analizados, se observó una diferencia entre el grupo de hombres y mujeres en los valores de rigidez hepática; estos mismos resultados se observaron en otros estudios. En el estudio de Suh y colaboradores (19), con 196 donantes potenciales para trasplante de hígado con donante vivo, el rango de referencia para la elasticidad hepática normal confirmada por biopsia fue 2,6-6,2 kPa, con una elasticidad media de 4,4 kPa. El valor medio de elasticidad hepática normal en nuestro estudio fue 4,28 kPa, que está en concordancia con los datos de Suh (en cuyo estudio la mayoría eran sujetos delgados similares a los nuestros) y con valores obtenidos en voluntarios sanos sin corroboración histológica (4,6-4,9 kPa) (20).…”

Section: Discussionunclassified

Elastografía en tiempo real (supersonic): comportamiento de la prueba en sujetos sanos de Bogotá

Ortiz

Pardo

Ortíz

et al. 2017

Rev. Colomb. Gastroenterol.

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Introducción: La elastografía en tiempo real (Supersonic), es una prueba no invasiva que se utiliza para determinar la elasticidad del hígado y de esa forma calcular el grado de fibrosis hepática; en algunas ocasiones reemplaza la toma de la biopsia hepática y es útil para el seguimiento de la mayoría de pacientes con hepatopatías. En Colombia, la prueba se introdujo recientemente y no existen hasta el momento estudios del comportamiento de la prueba en personas sanas.Objetivo: Evaluar el comportamiento de la elastografía en tiempo real en sujetos sanos en Bogotá Materiales y métodos: Estudio piloto retrospectivo de sujetos sanos entre 15 y 37 años, entre el 1 de junio de 2016 y el 31 de marzo del 2017. Se realizaron la historia clínica y la evaluación básica de la función hepática para descartar anormalidades. Resultados: La serie incluyó 33 sujetos sanos, 60,6 % mujeres y 39,4 % hombres con una edad promedio de 24,8 años. Al practicar la prueba se encontró un valor promedio de 4,28 kilopascales (kPs), con una diferencia mínima entre sexos, siendo mayor la rigidez hepática en los hombres.Conclusiones: Los valores promedio de la rigidez hepática en 33 sujetos sanos en Bogotá son los mismos reportados en los estudios iniciales de las pruebas a nivel internacional, estos hallazgos sugieren que la prueba puede ser muy útil en nuestro medio para la evaluación de pacientes con hepatopatías.

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“…In three studies, the intraobserver reproducibility of SSI during the same session was excellent (ICC ranged from 0.92 to 0.95) [23,73,118]. The interobserver agreement on different days was affected by operator experience and ranged from 0.63 to 0.84 [23,118].…”

Section: Reproducibility In Healthy Subjectsmentioning

confidence: 92%

“…2D-SWE measurements of Young's modulus using supersonic shear imaging (SSI) in healthy subjects cover the range 4.5 -5.5 kPa (95 th percentile 6.2 kPa) [73,74]. Healthy men may have higher LSMs than healthy women, while BMI and age do not seem to influence LSM in subjects without liver disease [74].…”

Section: Recommendationmentioning

confidence: 99%

Untitled

2017

Ultraschall in Med

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Determination of Normal Hepatic Elasticity by Using Real-time Shear-wave Elastography

Abstract: Hepatic elasticity values measured with SWE in histologically proven normal livers ranged from 2.6 to 6.2 kPa, with high measurement reliability. The effect of the potential confounding factors on liver elasticity was negligible.

Cited by 78 publications

References 32 publications

Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of Shear Wave Elastography with Serologic Tests

Non-Invasive Assessment of Liver Fibrosis in a Rat Model: Comparison of Shear Wave Elastography with Serologic Tests

Elastografía en tiempo real (supersonic): comportamiento de la prueba en sujetos sanos de Bogotá

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