Determination of NS3 inhibitors drug resistance mutations in chronic Hepatitis C patients infected with genotype 1

Şanlıdağ, Tamer; Sayan, Murat; Akçalı, Sinem; Kasap, Elmas; Buran, Tahi̇r; Arıkan, Ayşe

doi:10.1016/j.jbiotec.2017.06.1087

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“…The Y93H is a mutation related to cross-resistance in the NS5A inhibitor group (34). However, Y93H mutation was the first case to be reported in Turkey (35,36). These findings suggested the resistance analysis, as experienced in CHC patients on therapy should remain a basic part of the management.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Direct Acting Antivirals Efficiency in Turkish Patients with Chronic Hepatitis C Under Strict Rules

Sarıgül¹,

Sayan

User³

et al. 2019

Hepat Mon

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In chronic hepatitis C treatment, direct acting antivirals have a strong effect and are well tolerated since 2014, yet it is unclear whether resource-constrained countries have the same achievement. This study aimed at evaluating direct acting antivirals used to treat Turkish chronic hepatitis C patients between the years of 2016 to 2017. Within the one-year period, 101 out of 105 patients reached a sustained virological response rate. The type of direct acting antivirals and treatment length were chosen according to the Health Implementation Guideline of Turkey. The analyses of effectiveness according to therapeutic regimes showed the following sustained virological response rate: Ledipasvir/sofosbuvir and +/-; ribavirin (97%), ombitasvir/paritepravir/dasabuvir and +/-; ribavirin (100%) and sofosbuvir + ribavirin (100%). One patient had virological relapse on the 12th week by the end of the therapy. In this patient, cross-resistance mutation Y93H was specified for the NS5A region. On the other hand, amino acid changes, S282G and C316S, were determined in the NS5B region. The adverse effects were 22% in all patients. Most of them were mild or moderate. The researchers concluded that the results of the highly efficient and well-tolerated therapy with direct acting antivirals could be examples in resource-constrained countries. In addition, resistant variants should be detected after unsuccessful treatment in the management of new therapy options.

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Section: Discussionmentioning

confidence: 99%