Determination of Nucleation and Growth Mechanisms of the B Polymorph of <i>L</i>‐Histidine by Induction Time Measurement

Wantha, Lek

doi:10.1002/ceat.201600045

Cited by 11 publications

(16 citation statements)

References 17 publications

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“…The obtained photomicrographs of the prepared crystals of forms A and B indicated that the crystals of form A exhibited rod‐like shapes consistent with those reported in previous works , , . The shape of crystals of form B appeared plate‐like like those reported in former works , , .…”

Section: Resultssupporting

confidence: 88%

“…Pure crystals of form A of L ‐his were produced from aqueous solution crystallization by cooling operation at 25 °C as described in previous works , , , . A saturated aqueous solution of L ‐his at 45 °C was prepared at 50 °C and then the solution was cooled rapidly to 10 °C.…”

Section: Methodsmentioning

confidence: 99%

“…In literature, L ‐his is known to crystallize in a metastable polymorph B and a stable polymorph A , , . Kitamura et al , studied the formation and transformation of polymorphs of L ‐his by rapidly cooling aqueous and ethanol‐water solutions.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L‐Histidine

2019

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Solution-mediated polymorphic transformation (SMPT) of the metastable polymorph B of L-histidine (L-his) into the stable polymorph A in water-antisolvent solutions was performed. Methanol, acetone, and acetonitrile served as antisolvents. The SMPT was studied via nucleated batch antisolvent crystallization process by determining the change of the fraction of the stable polymorph A of L-his in the crystal phase with time during the crystallization process. The fraction of the stable polymorph A of L-his was assessed offline by Raman spectroscopy. The transformation time depended on the fractions of form A obtained at the initial stage of crystallization. The transformation rate of the metastable polymorph B into the stable polymorph A at lower antisolvent volume fraction was faster than at higher antisolvent volume fraction. The transformation time of polymorph B into polymorph A in water-acetonitrile solution was the shortest compared to the other solutions.

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Section: Resultssupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

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Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L‐Histidine

2019

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“…The data include the solubility as a function of temperature because the solubility of L ‐his increases with temperature . There are reports of the dissolution rate of form B and the growth rate of form A of L ‐his in aqueous solution , and the nucleation and growth mechanisms of form B of L ‐his in the water‐ethanol system .…”

Section: Introductionmentioning

confidence: 99%

Antisolvent Crystallization of Polymorphs of L‐Histidine

2018

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Antisolvent crystallization is the most common method to study solvent effects on polymorphic crystallization. L‐Histidine (L‐his) served as a model substance. Acetonitrile, acetone, and methanol were selected as antisolvents, with water as solvent. The formation of L‐his polymorphs in antisolvent crystallization as a function of supersaturation, antisolvent volume fraction, and temperature was studied. The solubility of polymorph A of L‐his decreased with increasing volume fraction of antisolvent and increased with higher temperature. The metastable polymorph B of L‐his was obtained at higher antisolvent volume fraction and supersaturation. At lower antisolvent volume fraction and supersaturation, a mixture of polymorphs A and B was detected.

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“…In CNT, − the nucleation rate, J (/m 3 s), is described as where A is the pre-exponential factor, with unit of/m 3 s. R is the ideal gas constant. T is the nucleation temperature, with unit of K .…”

Section: Theorymentioning

confidence: 99%

Interaction of Metastable Zone Width and Induction Time Based on Nucleation Potential

Yan

et al. 2020

Ind. Eng. Chem. Res.

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The induction times at supersaturation of 1.15 -1.24 and the metastable zone widths with cooling rates of 6.0 -30.0 K/h have been determined in the system of dicyandiamide and water. A model based on accumulation of nucleation potential, derived from the classical nucleation theory, has been appliedto estimate the critical nucleation potential and pre-exponential factor for both experimental results of induction times and metastable zone widths. The estimation values were fairly agreed with the experimental values. The preexponential factor was assumed to be constant in the model, while the modifications of pre-exponential factor, dependent on the supersaturation, has been introduced to the model, for a more consistent estimations between the induction time and metastable zone width.

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Determination of Nucleation and Growth Mechanisms of the B Polymorph of L‐Histidine by Induction Time Measurement

Cited by 11 publications

References 17 publications

Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L‐Histidine

Influence of Solvents on Solution‐Mediated Polymorphic Transformation of the Polymorphs of L‐Histidine

Antisolvent Crystallization of Polymorphs of L‐Histidine

Interaction of Metastable Zone Width and Induction Time Based on Nucleation Potential

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