Chemical flooding methods improve oil extraction after standard waterflooding processes. Chemical EOR methods modify different properties of fluids and/or rock to mobilize the remaining oil. It is expected that the residual oil will be different in properties than conventional. A new technology is presented to study a surfactant–polymer flooding, based on a periodic sampling and measuring properties of oil and water during 15 months. The study area is a terrigenous reservoir with 3 chemical injection wells and 16 production wells. High-precision mass spectrometry methods were carried out on each sample, which made it possible to evaluate the effectiveness of ongoing work on chemical flooding. At each sampling date, 2D reservoir model was built to track these changes in the study area. It is shown that the composition of the water has changed - highly permeable channels were closed and formation waters were involved in the production. The properties of oil have also changed - depending on the site of impact, there are areas with more degraded oil in production after the injection of chemicals. Geochemical monitoring shows the redistribution of filtration flow directions in the reservoir volume.