In techno-economic concern, cut-off grade (COG) optimization is the key for efficient mineral liquidation from the huge metalliferous surface mining sector. In this paper, a sequentially advancing algorithm based on exact multi-value dynamic programming (MDP) has been developed to determine the optimum COG of an open-pit metalliferous deposit. The proposed COG optimization algorithm aims to overcome the limitations of straightforward classical techniques in determining the optimum COG. This discrete COG-MDP model is the first of its kind and has the novelty of dealing with the simulation of eight dynamic possibilities to achieve the maximal Net Present Value (NPV). A high-level programming language (Python) has been used to develop the computer model to deal with the complexity of handling a minimum of 500 series of dynamic variables with a precision value of 0.01% in grade bins. This model can generate results in polynomial-time from the complex mine, mill, and smelter and refinery system corresponding to various limiting conditions. The prime objective considered in the model is to optimize the COG of a metalliferous deposit. The model validation has been done using a real-life case study of an open-pit copper mine in India (Malanjkhand Copper Mine, HCL), considering the fixed yearly output of the mining, milling, and smelting and refining. In this study, the optimum COG for the Malanjkhand copper deposit has been found to be (0.33%, 0.23%, 0.52%, 0.26%, 0.27%, 0.22%, 0.24%) with a maximum NPV of ₹ (12204, 14653, 16948, 14609, 21454, 26717, 38821) million corresponding to various scenarios. The findings also show that the present value of net cash-flow grows in the early years, peaks at a specified mid-life time, and then drops as the reserve is depleted. The present value gradually hits zero after the project’s life cycle, confirming the typical pattern of other mining firms.