Determination of pKa of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration
Alexandra V. Ivoilova,
Polina N. Mozharovskaia,
Liya V. Mokrousova
et al.
Abstract:In this work, for the first time, an approach was suggested for determining the pKa of triazolo[5,1-c][1,2,4]triazine compounds in N,N-dimethylformamide using potentiometric titration. It was noted that change in system potential in the titration curves of triazolo[5,1-с][1,2,4]triazine are observed for compounds containing either H+ located at the nitrogen atom in position 1 or an –NH2 group. The calculated pKa values of the studied molecules correspond to the pKa values of moderately strong acids and are in … Show more
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