Determination of paracetamol and its metabolites via LC-MS/MS in dried blood volumetric absorptive microsamples: A tool for pharmacokinetic studies

Delahaye, Lisa; Baerdemaeker, Luc De; Stove, Christophe

doi:10.1016/j.jpba.2021.114361

Cited by 9 publications

(3 citation statements)

References 33 publications

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“…Based on the chemical structure, paracetamol, and caffeine contain the UV chromophore, so these analyts can be detected by UV. Previous studies were reported paracetamol in herbs powder spectrophotometry (Sari, et al, 2021), FT-IR (Wahyuningsih, et al, 2022), highperformance liquid chromatography (HPLC) (Laksmi, et al, 2016;Wisnuwardani, et al, 2018;Mamat, et al Sari, et al, 2021), high-performance thin layer chromatography (HPTC) (Mahesh, et al, 2011;Prawez, et al, 2022), LC/MS/MS (Delahaye, et al, 2021). However, a simple, fast, selective, and inexpensive method for routine analysis is still preferred.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Paracetamol and Caffeine in Jamu Powders Simultaneously Using TLC-Densitometry

Wahyuningsih,

Isnaeni

2023

bikfar

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Paracetamol and caffeine are chemical compounds that are suspected to be illegally added to the traditional herbs claimed as rheumatics drugs. Identification of paracetamol and caffeine has been done on five samples of jamu powder obtained from the Depot Jamu in Surabaya. This study aimed to simultaneously identify paracetamol and caffeine commonly found in traditional medicine one of which is jamu powder using thin-layer chromatography densitometry (TLC-Densitometry). Evaluate the presence of paracetamol and caffeine in the product of jamu was performed by thin layer chromatography with silica gel GF254 and chloroform-ethyl acetate (1:1) as the stationary and mobile phase respectively. The spots on the TLC plate were detected using a UV at 254 nm and the areas were measured by a Camag TLC scanner. The TLC profile demonstrated a good separation of paracetamol, caffein, and others substances that containing in the products. The retardation factor (Rf) of paracetamol and caffeine were 0,42 and 0,26 with a detection limit of 0,0125 µg/spot and 0,05 µg/spot respectively. The simultaneous identification of caffeine and paracetamol by using thin-layer chromatography densitometry revealed that none of the five samples were detected to contain paracetamol and caffeine. Keywords: Simultaneously, Identification, Paracetamol, Caffeine, Jamu Powder, TLC- Densitometry

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Section: Introductionmentioning

confidence: 99%

“…The TLC allows for greater flexibility in the choice of chromatographic system. The method is simpler, more rapid, and lower cost than HPLC and LC/MS/MS (Delahaye, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Identification of Paracetamol and Caffeine in Jamu Powders Simultaneously Using TLC-Densitometry

Wahyuningsih,

Isnaeni

2023

bikfar

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“…This novel dried blood sampling approach enables more accurate and precise blood volume collection than DBS (25). Antibiotics (26), antiseizure medication (27), and paracetamol (28) were among the drugs that have been investigated using VAMS.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Microsampling and Conventional Sampling Techniques for Quantification of Warfarin in Blood Samples: A Systematic Review

Mulyadi

Harahap

Muliawan

2023

sciphar

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Warfarin is a vitamin K antagonist (VKAs) anticoagulant associated with interindividual patients’ response to therapy, narrow therapeutic index, and serious adverse drug events. Monitoring ensures efficacy and safety by measuring drug concentration in the bloodstream, which demands blood or plasma samples from patients through conventional sampling. Conventional sampling often requires invasive methods that may be uncomfortable for patients. Microsampling offers an opportunity to reduce the burden of multiple blood sampling on patients and simplifies the process of sample transportation and storage. This systematic review describes conventional and microsampling techniques for quantifying warfarin in human blood samples and the bioanalytical method employed to perform the analysis. Related studies (537) were screened from several databases and narrowed down into 12 eligible articles, which were then used to fulfill the purpose of this review in a narrative form. It is concluded that while there are still limited studies regarding the application of microsampling for warfarin quantification in patients, there has been evidence of comparable plasma and micro samples results, highlighting the potential for future development of routine monitoring using the microsampling technique.

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Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos

Wang,

Kang,

et al. 2024

Bull Environ Contam Toxicol

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Determination of paracetamol and its metabolites via LC-MS/MS in dried blood volumetric absorptive microsamples: A tool for pharmacokinetic studies

Cited by 9 publications

References 33 publications

Identification of Paracetamol and Caffeine in Jamu Powders Simultaneously Using TLC-Densitometry

Identification of Paracetamol and Caffeine in Jamu Powders Simultaneously Using TLC-Densitometry

Comparison of Microsampling and Conventional Sampling Techniques for Quantification of Warfarin in Blood Samples: A Systematic Review

Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos

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