Determination of paroxetine in geriatric depression by high-performance liquid chromatography

Zainaghi, Isis A.; Lanchote, Vera Lúcia; Queiróz, Regina Helena Costa

doi:10.1016/s1043-6618(03)00098-7

Cited by 20 publications

(13 citation statements)

References 22 publications

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“…195 Paroxetine is derivatized with pentafluorobenzyl carbamate or heptafluorobutyric anhydride before injection onto a GC-MS in negative chemical ionization mode or on a GC-ECD configuration. 298−300 In LC, the following detectors are used: UV, 147,228,229,301,302 DAD, 146 fluorescence, 50,57,147,232,303,304 coulometric detection, 305 and mass detectors in electrospray 152,306,307 as well as in APCI mode. 153 When using the UV detector, a typical spectrum arises in acidic conditions at absorption of 233, 264, 270 and 293 nm.…”

Section: Methodsmentioning

confidence: 99%

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Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Wille

Cooreman

Neels

et al. 2008

Critical Reviews in Clinical Laboratory Sciences

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2 This review provides specific information concerning the interpretation and usefulness of antidepressant drug monitoring. Fifteen antidepressants (ADs) were selected based on their importance in the 7 major markets (Japan, USA, France, United Kingdom, Italy, Spain, Germany) according to the Cognos Plus Study #11. Literature data were reviewed concerning monitoring of the tricyclic ADs amitriptyline, clomipramine, imipramine, and new generation antidepressants such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, mianserin, mirtazapine, bupropion, and milnacipran. In addition, St.-John's Wort was added as this natural antidepressant is very popular in Europe. The objectives of therapeutic drug monitoring (TDM) for old and new generation ADs differs, as older ADs have narrow therapeutic windows with higher risks of severe drug interactions, while the new ADs have a wide therapeutic range, but an unclear plasma concentration-effect relationship. Therefore, the purpose of TDM for new-generation ADs leads more to the monitoring of patient compliance and special patient groups such as the elderly, patients with liver and kidney impairment, patients with poor metabolism by CYP 450 and comedication with inhibitors and inducers of those enzymes.Keywords Depression, monoamine oxidase inhibitors, noradrenergic and specific serotonergic antidepressants, serotonin-antagonist and reuptake inhibitors, selective noradrenaline reuptake inhibitors, selective serotonin reuptake enhancer, selective serotonin reuptake inhibitors, serotonin and noradrenaline reuptake inhibitors, tricyclic antidepressants, therapeutic drug monitoring, analytical methods, St. John's Wort. 25Critical Reviews in Clinical Laboratory Sciences Downloaded from informahealthcare.com by Dokuz Eylul Univ. on 11/05/14For personal use only. 26 S. M. R. Wille et al.

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Section: Methodsmentioning

confidence: 99%

“…Sample preparation usually consists of a liquid-liquid extraction after alkalinization, 50,57,298,299,302,307,309 although many SPE methods 57,147,152,155,193,229,304 have been published. Most methods allow quantitative determination in the lower ng/ml range (LOQ between 1-5 ng/ml), and are thus suitable for TDM.…”

Section: Methodsmentioning

confidence: 99%

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Wille

Cooreman

Neels

et al. 2008

Critical Reviews in Clinical Laboratory Sciences

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“…The methods reported for quantitative determination of PRX in tablets and/or biological fluids include voltammetry [5, 6], densitometry [7, 8], high-performance liquid chromatography [9–14], gas chromatography [15–17], and capillary electrophoresis [18]. These methods offered the required sensitivity and selectivity for the analysis of PRX in biological fluids; however, their sophisticated instrumentation and high analysis cost limited their routine use in quality control laboratories for analysis of PRX in its pharmaceutical tablets.…”

Section: Introductionmentioning

confidence: 99%

Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2‐Naphthoquinone‐4‐Sulphonate as a Chromogenic Reagent

Darwish

Abdine

Amer

et al. 2009

International Journal of Analytical Chemistry

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Simple and rapid spectrophotometric method has been developed and validated for the determination of paroxetine (PRX) in tablets. The proposed method was based on nucleophilic substitution reaction of PRX with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium to form an orange-colored product of maximum absorption peak (λ max) at 488 nm. The stoichiometry and kinetics of the reaction were studied, and the reaction mechanism was postulated. Under the optimized reaction conditions, Beer's law correlating the absorbance (A) with PRX concentration (C) was obeyed in the range of 1–8 μg mL−1. The regression equation for the calibration data was: A = 0.0031 + 0.1609 C, with good correlation coefficients (0.9992). The molar absorptivity (ε) was 5.9 × 105 L mol−1 1 cm−1. The limits of detection and quantitation were 0.3 and 0.8 μg mL−1, respectively. The precision of the method was satisfactory; the values of relative standard deviations did not exceed 2%. The proposed method was successfully applied to the determination of PRX in its pharmaceutical tablets with good accuracy and precisions; the label claim percentage was 97.17 ± 1.06 %. The results obtained by the proposed method were comparable with those obtained by the official method.

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“…Because of the ever-increasing need for analytical methods with high sample-throughput, low limits of detection, and low maintenance costs, new methodologies are constantly being developed. During the past 6 years the majority of these methods were based on chromatography; high-performance liquid chromatography coupled with ultraviolet/diode array [1][2][3][4][5][6][7][8][9][10][11], mass [12][13][14][15][16][17][18], fluorimetric [19,20], and coulometric [21] detectors; gas chromatography with mass [22][23][24], flame-ionisation [25], nitrogen-phosphorus [26] and electron-capture [27] detection; micellar electrokinetic capillary chromatography [28]; and thin layer chromatography [9,29]. Capillary electrophoresis [30][31][32], flowinjection analysis with ultraviolet detection [33], and visible spectrophotometry [34,35] have also been applied in the analysis of PRX.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical determination of paroxetine in pharmaceuticals

Nouws

Delerue–Matos

Barros

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with SWAdSV detection (FIA-SWAdSV) were developed for the determination of paroxetine (PRX). The methods were based on the reduction of PRX at a mercury drop electrode at −1.55 V versus Ag/AgCl, in a borate buffer of pH 8.8, and the possibility of accumulating the compound at the electrode surface. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was also possible to determine PRX using FIASWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs. Both methods developed were validated and successfully applied to the quantification of PRX in pharmaceutical products.

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Determination of paroxetine in geriatric depression by high-performance liquid chromatography

Cited by 20 publications

References 22 publications

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Relevant Issues in the Monitoring and the Toxicology of Antidepressants

Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2‐Naphthoquinone‐4‐Sulphonate as a Chromogenic Reagent

Electroanalytical determination of paroxetine in pharmaceuticals

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