Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas—liquid chromatographic methods

Papp, O.; Valkó, Klára; Szász, G; Hermecz, István; Vámos, J; Hankó, K.; Ignáth-halász, Zs.

doi:10.1016/s0021-9673(01)88398-9

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1984

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Cited by 20 publications

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“…A similar method employing correlations between log K0K and retention times obtained from reversed-phase thin-layer chromatography (RP-TLC) has also appeared in the literature (18,22,23). This technique, although rapid and inexpensive to perform, suffers from the same inherent weaknesses as the RP-HPLC method.…”

Section: Introductionmentioning

confidence: 99%

Generator column determination of octanol/water partition coefficients for selected polychlorinated biphenyl congeners

Woodburn¹,

Doucette²,

Andrén³

1984

Environ. Sci. Technol.

115

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Section: Introductionmentioning

confidence: 99%

Generator column determination of octanol/water partition coefficients for selected polychlorinated biphenyl congeners

Woodburn¹,

Doucette²,

Andrén³

1984

Environ. Sci. Technol.

115

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Pyrido[1,2‐a]pyrimidines; New chemical entities in medicinal chemistry

Hermecz

1988

Medicinal Research Reviews

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Use of gas chromatographic retention indices for quantitative structure activity relationship studies of dialkyl phenyl phosphates

et al. 1990

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Thirty‐five dialkyl phenyl phosphates analogous to methyl and ethyl paraoxon were synthesized and their insecticidal activity against house fly (Musca nebulo) determined. Gas chromatographic retention indices (GCRI) at 200°C for all the phosphates were determined on OV‐101, DB‐1701 and DB‐WX fused‐silica capillary columns. The retention indices on polar and nonpolar columns (DB‐1701 and OV‐101, DB‐WX and OV‐101) considered together were shown to be related to the Hansch hydrophobic constant (II). Multiple regression analysis using the least‐square method was carried out to establish the linear relationships between insecticidal activity and GCRI along with the Hammett constant, (σ). The multiple correlation coefficients (r) of various parameters obtained using GCRI were found to be as significant as those obtained using II values. It was found that both hydrophobic and electronic effects made a significant contribution to the insecticidal activity of dialkyl phenyl phosphates. It is concluded that GCRI on two columns can be used directly as an indicator for hydrophobicity in QSAR studies provided that a suitable pair of polar and nonpolar columns is used for this purpose.

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Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas—liquid chromatographic methods

Cited by 20 publications

References 22 publications

Generator column determination of octanol/water partition coefficients for selected polychlorinated biphenyl congeners

Generator column determination of octanol/water partition coefficients for selected polychlorinated biphenyl congeners

Pyrido[1,2‐a]pyrimidines; New chemical entities in medicinal chemistry

Use of gas chromatographic retention indices for quantitative structure activity relationship studies of dialkyl phenyl phosphates

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