Determination of pedigrees and taxa of primates by protein electrophoresis

Lacy, Robert C.; Foster, Melissa L.; STAFF, THE PRIMATE DEPARTMENT

doi:10.1111/j.1748-1090.1987.tb01526.x

Cited by 3 publications

(8 citation statements)

References 13 publications

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“…The Baboon Island colony clearly has an extremely low level of genetic variability, a fact already apparent from previous studies (LAcy & FOSTER, 1988;TURNER et al, 1992). Such low levels of genetic variability revealed by DNA fingerprinting are extremely rare in natural populations, except where the underlying social system produces highly inbred individuals (e.g.…”

Section: Discussionmentioning

confidence: 73%

“…Since that time 40 -60 baboons have been continuously kept on the island, with about half being adult, and at no time since 1940 have any unrelated individuals been introduced into the colony. It has been presumed, therefore that there is considerable inbreeding in this population (LACY & FOSTER, 1988). Since 1970, maternity records have been kept, but the presence of multiple reproductively active males in the colony has prevented the assignment of paternity to specific individuals (LACY & FOSTER, 1988;TURNER et al, 1992).…”

Section: Introductionmentioning

confidence: 96%

“…It has been presumed, therefore that there is considerable inbreeding in this population (LACY & FOSTER, 1988). Since 1970, maternity records have been kept, but the presence of multiple reproductively active males in the colony has prevented the assignment of paternity to specific individuals (LACY & FOSTER, 1988;TURNER et al, 1992). During the period of this study seven males were actually or potentially reproductively active.…”

Section: Introductionmentioning

confidence: 96%

“…During the period of this study seven males were actually or potentially reproductively active. LACY and FOSTER (1988) have attempted to determine paternities in this colony using protein electrophoresis, however this proved impossible as of the 32 loci examined, 31 were invariant. Mean heterozygosity was 1.0070, compared with values from wild baboon populations of 3.9% for P.. h. papio (LuCOTTE, 1979), 1.8% (LucOTTE, 1979, 1.7%, and 2.9o/0 (SHOTAKE, 1981) for P. h. anubis, 2.8O/o for P.. h. cynocephalus (LuCOTTE, 1979), 3.6070 and 4.507o (SHOTAKE, 1981), and5.0070 (LucOTTE, 1979) for P h. hamadryas.…”

Section: Introductionmentioning

confidence: 99%

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DNA fingerprinting and the problems of paternity determination in an inbred captive population of guinea baboons (Papio hamadryas papio)

Bruford

Altmann

1993

Primates

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ABSTRACT. Multilocus DNA fingerprinting was carried out on 65 individuals from a captive colony of guinea baboons (Papio hamadryaspapio) at Brookfield Zoo, in order to determine the allocation of reproductive success among 7 active males. DNA fingerprinting was found to reveal very low levels of genetic variability in the study population, rendering discrimination of different levels of relatedness, and hence paternity, impossible. A method was therefore developed for emphasizing the region of the fingerprint pattern which revealed the greatest level of band variability, and the effect of this experimental modification on band sharing statistics was tested. Band sharing coefficients among unrelated individuals were significantly lower using the modified system, which was then applied to paternity testing in the whole population. However even when using the modified system, of the 33 offspring analyzed only 4 could be assigned solely to 1 male, 14 offspring were assigned to 1 of 2 males, 7 offspring had 3 potential fathers, and the remainder had 4 or more possible fathers. The implications of the limitations of these data for behavioural studies and genetic management of captive populations are discussed.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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DNA fingerprinting and the problems of paternity determination in an inbred captive population of guinea baboons (Papio hamadryas papio)

Bruford

Altmann

1993

Primates

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“…This study utilized genetic samples from two populations of savannah baboons and serum protein samples from one of these populations. The first set of samples was obtained from a captive breeding colony of Guinea baboons (Papio papio) in residence at the Brookfield Zoo in Brookfield, Illinois (Lacy and Foster, 1988;Bruford and Altmann, 1993 for the history of this population). DNA was extracted from whole blood from 65 individuals in the Brookfield colony for molecular genetic analysis, representing close to exhaustive sampling of this population.…”

Section: Materials and Methods Subjectsmentioning

confidence: 99%

Parallel effects of genetic variation in ACE activity in baboons and humans

Tung

Rudolph

Altmann

et al. 2007

American J Phys Anthropol

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Like humans, savannah baboons (Papio sp.) show heritable interindividual variation in complex physiological phenotypes. One prominent example of such variation involves production of the homeostatic regulator protein angiotensin converting enzyme (ACE), which shows heritable variation in both baboons and humans. In humans, this phenotypic variation is associated with an Alu insertion-deletion polymorphism in the ACE gene, which explains approximately half of the variation in serum ACE activity. We identified a similar Alu insertion-deletion polymorphism in the baboon ACE homologue and measured its frequency in a wild population and a captive population of baboons. We also analyzed the contribution of ACE genotype at this indel to variation in serum ACE activity in the captive population. When conditioned on weight, a known factor affecting ACE activity in humans, age and ACE genotype both accounted for variance in ACE activity; in particular, we identified a significant nonadditive interaction between age and genotype. A model incorporating this interaction effect explained 21.6% of the variation in residual serum ACE activity. Individuals homozygous for the deletion mutation exhibited significantly higher levels of ACE activity than insertion-deletion heterozygotes at younger ages (10-14 years), but showed a trend towards lower levels of ACE activity compared with heterozygotes at older ages (> or =15 years). These results demonstrate an interesting parallel between the genetic architecture underlying ACE variation in humans and baboons, suggesting that further attention should be paid in humans to the relationship between ACE genetic variation and aging.

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Captive breeding of squirrel monkeys, Saimiri sciureus and Saimiri boliviensis: The problem of hybrid groups

1998

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The electrophoretic variability of blood proteins coding for up to 32 genetic loci was analyzed in 108 squirrel monkeys (Saimiri sciureus, Saimiri boliviensis, hybrids) from two captive colonies. Twelve polymorphic loci with 31 alleles are reported. The biallelic Ada* locus, G-statistics and Hardy-Weinberg genotype equilibria are useful for recognizing hybrids between S. sciureus and S. boliviensis. Backcrosses in hybrid stocks and gene flow in a natural hybrid belt, however, complicate the taxonomic diagnosis of captive specimens: S. sciureus phenotypes imported from Peru possessed the allele Ada*132, which generally characterizes S. boliviensis (or species hybrids). The complex taxonomy of Saimiri spp. requires careful planning of captive breeding. We suggest a genetic analysis of the founder individuals before their inclusion in the European studbook population and to breed S. sciureus from Guyana separately from Peruvian imports, because the latter bear a greater risk of being taxonomically heterogeneous. Zoo Biol 17: 95-109, 1998.

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Determination of pedigrees and taxa of primates by protein electrophoresis

Cited by 3 publications

References 13 publications

DNA fingerprinting and the problems of paternity determination in an inbred captive population of guinea baboons (Papio hamadryas papio)

DNA fingerprinting and the problems of paternity determination in an inbred captive population of guinea baboons (Papio hamadryas papio)

Parallel effects of genetic variation in ACE activity in baboons and humans

Captive breeding of squirrel monkeys, Saimiri sciureus and Saimiri boliviensis: The problem of hybrid groups

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