Determination of pharmaceuticals and heavy metals in groundwater for human and animal consumption and crop irrigation in Galicia

Veiga-Gómez, María; Nebot, Carolina; Falqué, Elena; Perez, Benita; Franco, Carlos; Cepeda, Alberto

doi:10.1080/19440049.2021.1964702

Cited by 6 publications

(4 citation statements)

References 105 publications

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“…Thus, this may lead to the acquisition of drug resistance by the soil microflora 31 . After getting into the soil along with fertilizers, antibiotics can also get into groundwater and surface waters, posing a threat to humans and animals 32 . These results suggest that regular monitoring of antibiotics in fertilizers is needed to prevent the risk from excessive use of antibiotics in the livestock and proper management of their discharges to the environment.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of veterinary antibiotics in natural and organic fertilizers from animal food production and assessment of their potential ecological risk

et al. 2023

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BACKGROUND: Veterinary antibiotics are emerging contaminants and enter into soil principally by agricultural application of organic fertilizers. This article presents the results of the research obtained for the analyzed 70 samples of fertilizers (pig and poultry manure and slurry and digestate) for various classes of antibiotics.RESULTS: Doxycycline, oxytetracycline, tetracycline, lincomycin, tiamulin and enrofloxacin were found in tested samples. Doxycycline was found as a dominant compound, and its highest concentration was 175 mg/kg in pig manure. This investigation indicated that fertilization with manure, especially animal feces, might be the primary source of antibiotics. Additionally, a risk assessment based on a risk quotient was carried out, which showed that the determined concentrations of antibiotics in fertilizers may pose a threat to soil microorganisms. CONCLUSIONS: Results suggested that the ecological risk effects of antibiotic contamination on soil bases and their potential adverse risk on human health needs special attention.

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Section: Resultsmentioning

confidence: 99%

Prevalence of veterinary antibiotics in natural and organic fertilizers from animal food production and assessment of their potential ecological risk

et al. 2023

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“…It is also the predominant PPCP identified in this study. While griseofulvin has been reported to be present in surface and groundwater, 62,63 its carcinogenic risk to humans has not been calculated in previous research. Studies have suggested a carcinogenic effect of griseofulvin on experimental animals.…”

Section: Health Risk Assessmentmentioning

confidence: 94%

Occurrence and Health Risks of Organic Micropollutants in Tap Water in Dalian

Cai,

Tian,

Huang

et al. 2023

Chem. Res. Toxicol.

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“…Twenty-one different drugs were detected in water for human consumption, with the presence of anti-inflammatory, antihypertensive and psychiatric [ 9 ]. Seventeen pharmaceuticals were also detected in groundwater for human consumption in Galicia, with a concentration ranged between 21 and 14.9 µg/L [ 10 ]. Many articles reflect the problem of water contamination with pharmaceuticals, which in many areas are the source of drinking water, and this problem has been described in many countries around the world, including Spain [ 9 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…The therapeutic groups detected include, among others, antibiotics, antihypertensives, anti-inflammatories, glucocorticoids and antitumoral [ 11 ]. In ground water, another source of drinking water, pharmaceuticals have also been detected, and in some countries such as Spain, the frequency of detection reported in groundwater samples is more than 10% [ 10 , 16 , 17 ]. The frequency of detection changes from one area to another due to different factors such as prescription practices, excretion rate, chemical properties of the compounds, geological characteristics, and weather conditions.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Multi-Residue Method for Drugs Analysis in Human Feces by Liquid Chromatography–Tandem Mass Spectrometry

Míguez-Suárez¹,

Cardelle‐Cobas²,

Sinisterra-Loaiza³

et al. 2022

Molecules

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The use of veterinary drugs in animal production is a common practice to secure animal and human health. However, residues of administrated drugs could be present in animal food products. Levels of drugs in food of animal origin are regulated within the European Union. In recent years, residues have been detected not only in food, but also in the environmental elements such as water or soil, meaning that humans are involuntarily exposed to these substances. This article presents a multiclass method for the analysis of various therapeutic groups of pharmaceuticals in human feces. Pharmaceuticals are extracted from feces with an acid extraction solvent, and after filtration the extract was analyzed by HPLC–MS/MS. A limit of detection of 10 ng/g was achieved for 9 pharmaceuticals, with linearity over 0.99 and repeatability and reproducibility lower than 20%. The method was satisfactorily applied in 25 feces samples of individuals that had declared not to be under medical treatment for the last two months. Results indicate the presence of six different compounds at concentration between 10 and 456 ng/g. This preliminary study showed the involuntary exposure of human gut microbiota to active substances such as pharmaceuticals

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Determination of pharmaceuticals and heavy metals in groundwater for human and animal consumption and crop irrigation in Galicia

Cited by 6 publications

References 105 publications

Prevalence of veterinary antibiotics in natural and organic fertilizers from animal food production and assessment of their potential ecological risk

Prevalence of veterinary antibiotics in natural and organic fertilizers from animal food production and assessment of their potential ecological risk

Occurrence and Health Risks of Organic Micropollutants in Tap Water in Dalian

Development and Validation of Multi-Residue Method for Drugs Analysis in Human Feces by Liquid Chromatography–Tandem Mass Spectrometry

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