Determination of phentermine, N -hydroxyphentermine and mephentermine in urine using dilute and shoot liquid chromatography–tandem mass spectrometry

Choi, Yun Jeong; Sim, Arum; Kim, Min Kyung; Suh, Sunglll; In, Moon Kyo; Kim, Jin Young

doi:10.1016/j.jchromb.2016.06.045

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…9,10 Urine is also commonly utilized in anti-obesity drug testing since it contains both the drug itself and its metabolites. [11][12][13] Additionally, the concentration of anti-obesity drugs in urine remains signicantly higher than in plasma and oral uids. 14 Despite these advantages, testing anti-obesity drugs in urine can pose challenges due to the need for pre-processing procedures to overcome matrix effects and address insufficient limits of detection (LODs) in urine samples.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry

Jiang,

Zhao,

Yan

et al. 2023

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

“…9,10 Urine is also commonly utilized in anti-obesity drug testing since it contains both the drug itself and its metabolites. 11–13 Additionally, the concentration of anti-obesity drugs in urine remains significantly higher than in plasma and oral fluids. 14…”

Section: Introductionmentioning

confidence: 99%

Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry

Jiang,

Zhao,

Yan

et al. 2023

Anal. Methods

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Mephentermine dependence induced psychosis: A case report and a review of literature

Roshan,

2024

Psychiatry Research Case Reports

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Synthesis of Phentermine and its Derivatives

Khushbu

Shruti

Meena

et al. 2024

COS

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In recent years, a growing global concern has been obesity. Patients with obesity are at major risk for developing several diseases. These diseases may significantly impact patients’ daily lives and increase the mortality rate [1]. Over a year, medication for obesity has undergone substantial changes. An amphetamine-like prescription drug called Phentermine (Adipex-P, Lomaira) appetite. In the last few years, Phentermine and its derivatives have attracted much attention due to their use in weight reduction; by reducing appetite or prolonging the feeling of fullness, it can aid in weight reduction. So, reviewing the synthesis of Phentermine and its derivatives becomes imperative. Therefore, various synthetic routes for Phentermine (from benzaldehyde, isopropyl phenyl ketone, dimethyl benzyl carbinol) and its derivatives synthesis, involving ortho-palladation, are also reviewed here comprehensively.

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Determination of phentermine, N -hydroxyphentermine and mephentermine in urine using dilute and shoot liquid chromatography–tandem mass spectrometry

Cited by 3 publications

References 17 publications

Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry

Analysis of 15 anti-obesity drugs in urine using thermal-assisted paper spray mass spectrometry

Mephentermine dependence induced psychosis: A case report and a review of literature

Synthesis of Phentermine and its Derivatives

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