Determination of Phenylpropanolamine Salts in Dosage Forms through Fluorescent Derivative Formation

Shankle, L.L.

doi:10.1002/jps.2600671137

Cited by 7 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of analytical methods have been reported for the determination of PPA mostly based on spectrophotometry [8,9], spectrofluorimetery [10], room temperature phosphorescence [11], fluoroimmunoassay [12], radioenzymic assay [13], Raman spectroscopy [14], capillary electrophoresis [15,16], thin layer [17], gas (GC) [18][19][20][21][22][23][24] and liquid chromatography (LC) [25][26][27][28][29][30][31][32][33][34]. The procedures based on GC and LC have been more frequently reported.…”

Section: Introductionmentioning

confidence: 99%

Capillary gas chromatographic determination of phenylpropanolamine in pharmaceutical preparation

Abbasi¹,

Bhanger²,

Khuhawar³

2006

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Capillary gas chromatographic determination of phenylpropanolamine in pharmaceutical preparation

Abbasi¹,

Bhanger²,

Khuhawar³

2006

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

“…A good guide to the work published is found as comprehensive monograph in analytical profiles for drugs [4]. Several analytical techniques have been reported for PPA determination either perse or in pharmaceutical preparations and biological fluids including; titrimetry [5], spectrophotometry [6], fluorimetry [7], HPLC [8], capillary electrophoresis [9], flow injection [10] and gas chromatography [11]. …”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric determination of certain CNS stimulants in dosage forms and spiked human urine via derivatization with 2,4-Dinitrofluorobenzene

Walash

El‐Enany

Saad

2011

Chemistry Central Journal

View full text Add to dashboard Cite

A new spectrophotometric method is developed for the determination of phenylpropanolamine HCl (PPA), ephedrine HCl (EPH) and pseudoephedrine HCl (PSE) in pharmaceutical preparations and spiked human urine. The method involved heat-catalyzed derivatization of the three drugs with 2,4-dinitrofluorobenzene (DNFB) producing a yellow colored product peaking at 370 nm for PPA and 380 nm for EPH and PSE, respectively.The absorbance concentration plots were rectilinear over the range of 2-20 for PPA and 1-14 μg/mL for both of EPH and PSE, respectively. The limit of detection (LOD) values were 0.20, 0.13 and 0.20 μg/mL for PPA, EPH and PSE, respectively and limit of quantitation (LOQ) values of 0.60 and 0.40 and 0.59 μg/mL for PPA, EPH and PSE, respectively. The analytical performance of the method was fully validated and the results were satisfactory. The proposed method was successfully applied to the determination of the three studied drugs in their commercial dosage forms including tablets, capsules and ampoules with good percentage recoveries. The proposed method was further applied for the determination of PSE in spiked human urine with a mean percentage recovery of 108.17 ± 1.60 for (n = 3). Statistical comparison of the results obtained with those of the comparison methods showed good agreement and proved that there was no significant difference in the accuracy and precision between the two methods. The mechanism of the reaction pathway was postulated.

show abstract

“…Due to its clinical advantages, PPA received a great interest. Several analytical techniques have been reported for PPA determination such as; titrimetry (4,5), spectrophotometry (6)(7)(8), flourimetry (9), Raman spectroscopy (10), NMR (11), HPLC (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), CE (16)(17)(18)(19)(20), flow injection (21,22), HPTLC (23), micellar chromatography (24)(25)(26)(27), ion pair chromatography (28) and GC (29).…”

Section: Introductionmentioning

confidence: 99%

A New Spectrophotometric Method for Determination of Phenylpropanolamine HCl in its Pharmaceutical Formulations via Reaction with 2,3,5,6-tetrachloro-1,4-benzoquinone

El-Enany,

Walash,

Saad

2010

Int. J Biomed Sci.

View full text Add to dashboard Cite

A selective and simple spectrophotometric method has been developed for the determination of phenylpropanolamine HCl (PPA) in its dosage forms. The method was based on the formation of a colored N-vinyl chlorobenzoquinone derivative of PPA through its reaction with 2,3,5,6-tetrachloro-1,4-benzoquinone in presence of acetaldehyde. The colored product exhibits maximum absorbance at 650 nm. Different experimental parameters affecting formation and stability of the product were carefully studied and optimized. The factors affecting the reaction were studied and optimized. The stoichiometry of the reaction was determined, and the reaction pathway was postulated. The absorbance concentration plot was rectilinear over the range of 5-100 µg/mL with Limit of Detection (LOD) and Limit of Quantitation (LOQ) of 0.244 µg/mL and 0.74 µg/mL respectively. The analytical performance of the method was fully validated, and the results were satisfactory. The proposed method was successfully applied to the determination of PPA in its commercial dosage forms including tablets, capsules and syrups with good recoveries. Statistical comparison of the results with those of the comparison method showed good agreement and proved that there was no significant difference in the accuracy and precision between the reference and the proposed methods. The mechanism of the reaction pathway was postulated.

show abstract

Determination of Phenylpropanolamine Salts in Dosage Forms through Fluorescent Derivative Formation

Cited by 7 publications

References 8 publications

Capillary gas chromatographic determination of phenylpropanolamine in pharmaceutical preparation

Capillary gas chromatographic determination of phenylpropanolamine in pharmaceutical preparation

Spectrophotometric determination of certain CNS stimulants in dosage forms and spiked human urine via derivatization with 2,4-Dinitrofluorobenzene

A New Spectrophotometric Method for Determination of Phenylpropanolamine HCl in its Pharmaceutical Formulations via Reaction with 2,3,5,6-tetrachloro-1,4-benzoquinone

Contact Info

Product

Resources

About