Determination of Pindone in Baits by using Time-Resolved Lanthanide-Sensitized Luminescence and Kinetic Methodology

Abstract

A simple and fast kinetic method for the determination of pindone in baits was developed. It is based on the inhibitory effect of this indanedione rodenticide on the luminescence of the europium(III)-thenoyltrifluoracetone system in the presence of cetyltrimethylammonium bromide. The relatively long lifetime of this system allows the time-resolved mode to be used, which eliminates any fluorescence signal. To avoid the potential static background signal of the sample, the difference between the initial rate obtained in the absence and presence of pindone is used as the analytical parameter, which is obtained within only 0.2 s with the aid of a stopped-flow mixing technique. The calibration graph is linear in the range 0.1-10.0 )•

Kinetic Determinations and Some Kinetic Aspects of Analytical Chemistry

“…Time-resolved lanthanide-sensitized luminescence has been used for the kinetic determination of p-aminobenzoic acid (104) and pindone (105). The former method is based on the of a complex with terbium(III) in the presence of trioctylphosphine oxide and Triton X-100.…”

Interaction of Pindone and its Tautomers with Calcium Dication – A DFT Study

“…Pindone inhibits the manufacture of blood clotting factors (prothrombin), leading to a reduction in the clotting ability of the blood. One of the advantages of pindone is the availability of an antidote in the case of accidental poisonings [6].…”

Tautomerism in Pindone – A DFT Study

“…This causes anticoagulant poisoning with a long latent period between ingestion and mortality, resulting in death due to internal haemorrhaging. One of the advantages of pindone is the availability of an antidote in the case of accidental poisonings [6].…”