2008
DOI: 10.1002/bmc.995
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Determination of plasma topiramate concentration using LC‐MS/MS for pharmacokinetic and bioequivalence studies in healthy Korean volunteers

Abstract: A rapid, simple and validated liquid chromatography coupled to tandem mass spectrometric method (LC-MS/MS) for topiramate analysis in human plasma has been applied to pharmacokinetic and bioequivalence studies in 24 healthy male Korean volunteers. The procedure involves a simple liquid extraction of topiramate and prednisone (internal standard) with acetonitrile and separation by HPLC equipped with a Capcell Pak C18 column using acetonitrile-0.1% triethylamine (80:20, v/v) as a mobile phase. Detection was carr… Show more

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Cited by 22 publications
(18 citation statements)
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“…For various reasons, including insufficient analytical sensitivity 12,23,24,26,28,29,31,35 and linearity, 24,25,[32][33][34]36 previously reported liquid chromatography techniques coupled with various detection systems can not accurately determine full therapeutic range of TPM concentrations. These methods either lack adequate sensitivity, and consequently cannot be applied in pharmacokinetic studies, or the method range is to narrow and therefore they are not practical for routine TDM.…”
Section: Clinical Application Of the Methodsmentioning
confidence: 99%
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“…For various reasons, including insufficient analytical sensitivity 12,23,24,26,28,29,31,35 and linearity, 24,25,[32][33][34]36 previously reported liquid chromatography techniques coupled with various detection systems can not accurately determine full therapeutic range of TPM concentrations. These methods either lack adequate sensitivity, and consequently cannot be applied in pharmacokinetic studies, or the method range is to narrow and therefore they are not practical for routine TDM.…”
Section: Clinical Application Of the Methodsmentioning
confidence: 99%
“…It needs to be emphasized that sensitivity of the present HPLC-FLD method is comparable to the sensitivity of the more sophisticated LC-MS methods, 30,[32][33][34]36 which makes it appropriate also for pharmacokinetic profiling and bioequivalence assessments of low-dose TPM formulations in healthy volunteers.…”
Section: Clinical Application Of the Methodsmentioning
confidence: 99%
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“…A commercial reagent-based FPIA method is available for the measurement of TPM in plasma or serum [219,220]. More recently, an improved GLC-NPD method was reported [221] and either GLC or HPLC with MS [222][223][224] and tandem MS detection have developed [221,225].…”
Section: Topiramate (Tpm)mentioning
confidence: 99%