Determination of poly(vinyl alcohol) via its complex with boric acid and iodine

Joshi, D.P.; Lan-Chun-Fung, Y.L.; Pritchard, Jane

doi:10.1016/s0003-2670(01)83825-3

Cited by 82 publications

(51 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The estimation of residual PVA coupled with NPs was based on colorimetric complex formation between two adjacent hydroxyl groups of PVA and an iodine molecule (30). Briefly, 2 mg of NP sample was reacted with 2 mL of 0.5 N NaOH for 15 min at 60°C which was subsequently neutralized with 900 μL of 1 N HCl, and the volume was adjusted to 5 mL with distilled water (DW).…”

Section: Estimation Of Residual Pvamentioning

confidence: 99%

Protein-Functionalized PLGA Nanoparticles of Lamotrigine for Neuropathic Pain Management

et al. 2014

View full text Add to dashboard Cite

Abstract. Lamotrigine (LTG), a sodium and calcium channel blocker, has demonstrated efficacy for the treatment of neuropathic pain in multiple, randomized, controlled trials. However, its potential clinical applications in neuropathic pain are limited due to the risk of dose-dependent severe rashes associated with high dose and prompt dose escalation. Further, the poor pharmacokinetic profile due to non-selective distribution to organs other than brain reduces the efficacy of dosage regimen. Therefore, the aim of present investigation is to develop surface-engineered LTG nanoparticles (NPs) using transferrin and lactoferrin as ligand to deliver higher amount of drug to brain and improve the biodistribution and pharmacokinetic profile of drug with prolonged duration of action and reduced accumulation in nontarget organs. The LTG NPs were prepared by nanoprecipitation and optimized by factorial design for high entrapment and optimized particle size. The optimized NPs were surface functionalized by conjugating with the lactoferrin (Lf) and transferrin (Tf) as ligands. The developed NPs were characterized for different physicochemical parameters and stability. The in vivo biodistribution showed preferential targeting to brain and reduced accumulation in non-target organs over a prolonged duration of time. Finally, partial sciatic nerve injury model was used to demonstrate the increased pharmacodynamic response as antinociceptive effect. Both biodistribution and pharmacodynamic study in mice confirmed that the approach used for LTG can help to increase clinical applications of LTG due to brain targeting and reduced side effects.

show abstract

Section: Estimation Of Residual Pvamentioning

confidence: 99%

Protein-Functionalized PLGA Nanoparticles of Lamotrigine for Neuropathic Pain Management

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Microparticle (MP) residual PVA content was studied by a colorimetric assay based on the reaction occurring between two adjacent hydroxyl groups of PVA and iodine molecule leading to the formation of a colored complex (Joshi et al, 1979).…”

Section: Preparation Of Coenzyme Q 10 Encapsulated Nanoparticlesmentioning

confidence: 99%

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Simón-Yarza

Tamayo

Benavides

et al. 2013

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Myocardial ischemia (MI) remains one of the leading causes of death worldwide.Angiogenic therapy with the vascular endothelial growth factor (VEGF) is a promising strategy to overcome hypoxia and its consequences. However, from the clinical data it is clear that fulfillment of the potential of VEGF warrants a better delivery strategy. On the other hand, the compelling evidences of the role of oxidative stress in diseases like MI encourage the use of antioxidant agents. Coenzyme Q 10 (CoQ 10 ) due to its role in the electron transport chain in the mitochondria seems to be a good candidate to manage MI but is associated with poor biopharmaceutical properties seeking better delivery approaches.The female Sprague Dawley rats were induced MI and were followed up with VEGF microparticles intramyocardially and CoQ 10 nanoparticles orally or their combination with appropriate controls. Cardiac function was assessed by measuring ejection fraction before and after three months of therapy.Results demonstrate significant improvement in the ejection fraction after three months with both treatment forms individually; however the combination therapy failed to offer any synergism. In conclusion, VEGF microparticles and CoQ 10 nanoparticles can be considered as promising strategies for managing MI.

show abstract

“…The amount of PVA associated with microparticles was determined by a colorimetric method based on the formation of a coloured complex between two adjacent hydroxyl groups of PVA and an iodine molecule [24,25]. Briefly, 2 mg of lyophilized microparticles samples were treated with 2 ml of 0.5 M NaOH for 15 min at 60 ºC.…”

Section: Determination Of Residual Pvamentioning

confidence: 99%

Sustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheres

Garbayo

Ansorena

Lanciego

et al. 2008

European Journal of Pharmaceutics and Biopharmaceutics

View full text Add to dashboard Cite

Determination of poly(vinyl alcohol) via its complex with boric acid and iodine

Cited by 82 publications

References 13 publications

Protein-Functionalized PLGA Nanoparticles of Lamotrigine for Neuropathic Pain Management

Protein-Functionalized PLGA Nanoparticles of Lamotrigine for Neuropathic Pain Management

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Sustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheres

Contact Info

Product

Resources

About