Determination of polybrominated diphenyl ethers in fish tissues by matrix solid-phase dispersion and gas chromatography coupled to triple quadrupole mass spectrometry: Case study on European eel (Anguilla anguilla) from Mediterranean coastal lagoons

Labadie, Pierre; Alliot, Fabrice; Bourges, Catherine; Desportes, Annie; Chevreuil, Marc

doi:10.1016/j.aca.2010.07.010

Cited by 57 publications

(32 citation statements)

References 37 publications

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“…As described by Labadie et al 2010, POPs levels were blank corrected and the method detection limit (LoD) was derived from the blank value variability, For PCBs LoQs were comprised between 0.2 and 2 ng/g dw; for OCPs they were comprised between 0.1 and 0.4 ng/g dw; for PBDEs they were comprised between 0.1 and 0.2 ng/g dw.…”

Section: Organic Pollutants Analysesmentioning

confidence: 99%

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

et al. 2014

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Identifying specific effects of contaminants in a multi-stress field context remain a challenge in ecotoxicology. In this context, ''omics'' technologies, by allowing the simultaneous measurement of numerous biological endpoints, could help unravel the in situ toxicity of contaminants. In this study, wild Atlantic eels were sampled in 8 sites presenting a broad contamination gradient in France and Canada. The global hepatic transcriptome of animals was determined by RNA-Seq. In parallel, the contamination level of fish to 8 metals and 25 organic pollutants was determined. Factor analysis for multiple testing was used to identify genes that are most likely to be related to a single factor. Among the variables analyzed, arsenic (As), cadmium (Cd), lindane (c-HCH) and the hepato-somatic index (HSI) were found to be the main factors affecting eel's transcriptome. Genes associated with As exposure were involved in the mechanisms that have been described during As vasculotoxicity in mammals. Genes correlated with Cd were involved in cell cycle and energy metabolism. For c-HCH, genes were involved in lipolysis and cell growth. Genes associated with HSI were involved in protein, lipid and iron metabolisms. Our study proposes specific gene signatures of pollutants and their impacts in fish exposed to multi-stress conditions.

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Section: Organic Pollutants Analysesmentioning

confidence: 99%

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

et al. 2014

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“…High recovery rates (greater than 70%) were achieved for all twenty-eight PBDEs, including perbrominated BDEs, though high solvent consumption was necessary (more than 100 mL per 3 g of freeze-dried sample) [57]. Miniaturization of MSPD using C 18 and Florisil as dispersants and acetonitrile:water as eluting solvent resulted in lower sample size (0.1 g) and low sorbent (0.4 g) and solvent (2.6 mL) request, with satisfactory recoveries (between 55% and 130%) for tetra-and penta-BDEs [71].…”

Section: Integrated Extraction and Cleanupmentioning

confidence: 99%

“…It seems that, regardless of matrix fat content, a single SPE step is enough to yield adequate recovery rates [46,56,57,66,67], although more exhaustive cleanup (up to three sequential SPE) can also be employed, even for low fat samples [58,68]. Additionally, different eluents can be sequentially added for fractionation, thus separating PBDEs from MeO-PBDEs and OH-PBDEs, in order to improve chromatographic resolution [69].…”

Section: Solid-phase Extractionmentioning

confidence: 99%

“…Labadie and colleagues [57] used ultrasound assisted-MSPD with activated silica gel and sulphuric acid-impregnated silica gel, followed by sulphuric acid digestion and multilayer cartridge cleanup to promote complete lipid removal and elimination of matrix effects during instrumental analysis. High recovery rates (greater than 70%) were achieved for all twenty-eight PBDEs, including perbrominated BDEs, though high solvent consumption was necessary (more than 100 mL per 3 g of freeze-dried sample) [57].…”

Section: Integrated Extraction and Cleanupmentioning

confidence: 99%

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Polybrominated diphenyl ethers and metabolites – An analytical review on seafood occurrence

Cruz

Cunha

Marques

et al. 2017

TrAC Trends in Analytical Chemistry

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a b s t r a c tEnvironmental health is systematically compromised by persistent toxic substances, which may have serious implications in terms of food safety issues and, thus, in general public health. In this context, polybrominated diphenyl ethers (PBDEs) and their biologically active metabolites have been increasingly assessed in seafood, the main route of human exposure.As a consequence, a multiplicity of solvent-assisted analytical approaches is now available to accurately determine tiny amounts of these contaminants in complex matrices, like seafood. However, the majority of analytical procedures lead to high organic solvent consumption, thereby also contributing to the deterioration of environmental health.The current review provides up-to-date information and critical discussion regarding the most common methodologies applied in the determination of PBDEs and their metabolites in seafood (2006 e2016), from sample preparation to instrumental analysis. The ultimate goals of this comprehensive survey are to sensitize field researchers to work under the principles of green chemistry and to improve the global consciousness on the potential necessity of their regulation in foodstuffs.

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“…After analysis of PBDEs (see next section), F1 and F2 were combined, and the so-obtained extract was analyzed for PCBs (see next section). PBDE/PCB Analysis PBDE analysis was achieved using an Agilent 7890 A gas chromatograph coupled to an Agilent 7000 B triple quadripole mass spectrometer (GC-MS/MS; Agilent, Massy, France) as described by Labadie et al (2010a). PCB analysis was achieved with a 7890 A gas chromatograph coupled to a 5975 C mass spectrometer (Agilent Technologies).…”

Section: Extract Clean-up Proceduresmentioning

confidence: 99%

Influence of Hydrological Parameters on Organohalogenated Micropollutant (Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls) Behaviour in the Seine (France)

Tlili¹,

Labadie

Alliot

et al. 2011

Arch Environ Contam Toxicol

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The temporal dynamics of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) were investigated in a heavily urbanized river (Seine River, Paris, France) from November 2009 to May 2010. Pollutant concentrations were in the range of 0.2 to 3.8 ng l(-1) (median 1.1) and 0.4 to 3.6 ng l(-1) (median 1.1) for ∑ tri-deca BDEs and ∑ 7PCBs, respectively. In addition, for both PBDEs and PCBs, the partitioning between the particulate and dissolved phases was investigated. Due to their low water solubility, PBDEs were mainly (>70%) bound to particles. In contrast, only 54% of ∑ 7PCBs occurred in the particulate phase, and their partitioning was influenced by the degree of chlorination. During the sampling period, PBDE/PCB fluxes were quite similar and ranged from 3 to 128 and from 6 to 125 g day(-1), respectively. The annual mass flow of PBDEs and PCBs was estimated to 10 kg for both. Contrary to PCBs and BDE-209, the temporal evolution of ∑ tri-hepta BDEs was related to particulate organic matter content, which is controlled by river flow variations. This suggests that they exhibit different sources or behavior in the Seine River.

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Determination of polybrominated diphenyl ethers in fish tissues by matrix solid-phase dispersion and gas chromatography coupled to triple quadrupole mass spectrometry: Case study on European eel (Anguilla anguilla) from Mediterranean coastal lagoons

Cited by 57 publications

References 37 publications

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

Transcriptome profile analysis reveals specific signatures of pollutants in Atlantic eels

Polybrominated diphenyl ethers and metabolites – An analytical review on seafood occurrence

Influence of Hydrological Parameters on Organohalogenated Micropollutant (Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls) Behaviour in the Seine (France)

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