2023
DOI: 10.1016/j.jpba.2023.115291
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Determination of polymyxin B in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application in therapeutic drug monitoring

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Cited by 10 publications
(7 citation statements)
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“…31 Therefore, the concentrations of PMB were quantified by monitoring both PB1 and PB2 in this study and determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS; Shimadzu Jasper™ HPLC system coupled to an AB SCIEX Triple Quad™ 4500MD-ESI mass spectrometer, Singapore) with minor modifications to a previously described method. 15 The calibration curves showed acceptable linearity, ranging from 0.156 to 10 μg/mL for PB1 and from 0.0156 to 1.0 μg/mL for PB2. The accuracy of the intraday and interday studies ranged from 80.6% to 114.9%, and the coefficient of variation ranged from 2.6% to 14.8%.…”
Section: Sample Collection and Quantification Of Pmb Concentrationsmentioning
confidence: 83%
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“…31 Therefore, the concentrations of PMB were quantified by monitoring both PB1 and PB2 in this study and determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS; Shimadzu Jasper™ HPLC system coupled to an AB SCIEX Triple Quad™ 4500MD-ESI mass spectrometer, Singapore) with minor modifications to a previously described method. 15 The calibration curves showed acceptable linearity, ranging from 0.156 to 10 μg/mL for PB1 and from 0.0156 to 1.0 μg/mL for PB2. The accuracy of the intraday and interday studies ranged from 80.6% to 114.9%, and the coefficient of variation ranged from 2.6% to 14.8%.…”
Section: Sample Collection and Quantification Of Pmb Concentrationsmentioning
confidence: 83%
“…Among the four main components of PMB, PB1 and PB2 are the major components accounting for more than 85% of the mixture 31 . Therefore, the concentrations of PMB were quantified by monitoring both PB1 and PB2 in this study and determined using liquid chromatography–tandem mass spectrometry (LC–MS/MS; Shimadzu Jasper™ HPLC system coupled to an AB SCIEX Triple Quad™ 4500MD‐ESI mass spectrometer, Singapore) with minor modifications to a previously described method 15 . The calibration curves showed acceptable linearity, ranging from 0.156 to 10 μg/mL for PB1 and from 0.0156 to 1.0 μg/mL for PB2.…”
Section: Methodsmentioning
confidence: 99%
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“…The AB Sciex 4500 MD platform interfaced with Shimadzu (Kyoto, Japan) HPLC was employed for LC-MS/MS analysis. Chromatography was gradient-eluted with 0.2% FA (v/v) in acetonitrile and 0.2% FA (v/v) in water, and electrospray ionization (ESI) positive ion and multiple reaction monitoring (MRM) modes were used ( Huang et al, 2022 ; Zhang et al, 2023 ). Results showed that the polymyxin B concentrations of the peak and trough at a steady state were 4.30 mg/L and 1.48 mg/L, respectively.…”
Section: Case Descriptionmentioning
confidence: 99%