Determination of pravastatin in tablets by capillary electrophoresis

Kircali, Kevser; Tunçel, Muzaffer; Aboul‐Enein, Hassan Y.

doi:10.1016/j.farmac.2003.11.006

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…First of all, experiments under constant oxygen bubbling for 3 hrs. at different pHs (3,7,10) were carried out, obtaining that pravastatin was not oxidized in such experimental conditions. Therefore, a nitrogenous atmosphere was not necessary to perform the degradation trials.…”

Section: Resultsmentioning

confidence: 99%

Stability Study of Pravastatin Under Hydrolytic Conditions Assessed by HPLC

Brain-Isasi

Requena

Álvarez‐Lueje

2008

J. Chil. Chem. Soc.

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In this work an HPLC stability-indicating method was developed and applied to study the hydrolytic behavior of pravastatin in different pHs and temperatures.From the system suitability test, the selected chromatographic conditions were a C-18 column, acetonitrile-30 mmol L -1 phosphate buffer solution pH 2 (28:72) as mobile phase, 40ºC temperature column, a flux of 1 mL/min and 239 nm as wavelength detection. The developed method exhibited an adequate repeatability and reproducibility (CV 0.11% and 0.49%, respectively) and a recovery higher than 98%. Furthermore, the detection and quantitation limits were 3.4×10 -7 mol L -1 and 3.7×10 -6 mol L -1 . The kinetic degradation of pravastatin fits to a pseudo-first order kinetic. The degradation was pH-dependent: alkaline pH < acid pH and the generation of degradation products was dependent of the media tested (one product in alkaline medium and 4 products in acid medium). Activation energy, kinetic rate constants at different temperatures, t 1/2 and t 90 values are also reported.

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Section: Resultsmentioning

confidence: 99%

Stability Study of Pravastatin Under Hydrolytic Conditions Assessed by HPLC

Brain-Isasi

Requena

Álvarez‐Lueje

2008

J. Chil. Chem. Soc.

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“…Pınar Talay Pınar 1* , Tamer Tuluk 1 , Zühre Şentürk 2 [11,12], liquid chromatography-mass spectrometry [13][14][15][16], and capillary electrophoresis [17,18].…”

Section: Determination Of Pravastatin Drug Formulation By Squarewave Voltammetry On Glassy Carbon Elektrode Pravastatin'in Camımsı Karbonmentioning

confidence: 99%

“…Several analytical methods are available for the estimation of PRV in bulk form, pharmaceutical preparations and biological matrices, including high-performance liquid chromatography [7][8][9][10] [11,12], liquid chromatography-mass spectrometry [13][14][15][16], and capillary electrophoresis [17,18].…”

Section: Introductionmentioning

confidence: 99%

Pravastatin′in Camımsı Karbon Elektrot üzerinde Kare-dalga Voltametrisi ile İlaç Formülasyonunda Tayini

Pınar¹,

Tuluk²,

Şentürk

2020

Deu Muhendislik Fakultesi Fen Ve Muhendislik

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The electrochemical behavior of Pravastatin, a lipid-lowering drug, on a glassy carbon electrode was explored in Britton-Robinson buffer by using cyclic and square-wave voltammetry. Cyclic voltammetric studies indicated that the compound underwent irreversible oxidation, which was a diffusion-controlled process. Using square-wave voltammetry, Pravastatin could be determined at +1.24 V (vs. Ag/AgCl) in the concentration range 2.4×10-7-2.8×10-6 M at pH 2.0, with a detection limit of 5.0×10-8 M. The suggested method was successfully applied for the assay of Pravastatin in tablets.

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“…Literature survey reveals that pravastatin is official in British Pharmacopoeia (British Pharmacopoeia, 2007a). Several analytical methods are available for the estimation of pravastatin in bulk, pharmaceutical dosage forms and biological matrices, these include UV spectrophotometry (Balaji and Suman, 2009;Kunjan et al, 2014), visible spectrophotometry (Kalvikkarasi et al, 2009;Safwan and Mouhammed, 2011), HPLC (Bauer et al, 2005;Önal and Sagirli, 2006;Brain-Isasi et al, 2008;Safwan et al, 2008;Raj et al, 2010;Jane and Janivishal, 2013;Vania, 2014), LC-MS (Mulvana et al, 2000;Zhu and Neirinck, 2003;Kawabata et al, 2005;Sampath et al, 2011), capillary electrophoresis (Kircali et al, 2004;Nigovic and Vegar, 2008) and voltammetry (Nigović, 2006). Aspirin, chemically known as 2-acetyloxybenzoic acid (Figure 2), is a nonsteroidal anti-inflammatory drug used in the temporary relief of various forms of pain and inflammation associated with various conditions (Valentin and Joseph, 2011).…”

Section: Pravastatin Chemically Known As (3r5r)-7-[(1s2s6s8s8armentioning

confidence: 99%

Stability Indicating HPLC Method for the Simultaneous Quantification of Aspirin and Pravastatin in bulk and Tablets: Method Development and Validation

2017

J App Pharma Sci

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The aim of the present study was to develop and validate a stability indicating HPLC method for the simultaneous determination of aspirin and pravastatin in bulk and pharmaceutical dosage forms. The chromatographic separation of aspirin, pravastatin and their degradation products was achieved on Phenomex C18 column with mixture of water, acetonitrile and acetic acid (40:59:01, v/v/v) as mobile phase in an isocratic elution mode at a flow rate of 1.5 mL/min. The method exhibited linearity in the concentration range of 20.5 -61.5 μg/mL and 10-30 μg/mL for aspirin and pravastatin, respectively. The limits of detection and quantification were 0.204μg/mL and 0.680 μg/mL for aspirin and 0.077 μg/mL and 0.256 μg/mL for pravastatin, respectively. The developed method was validated with respect to accuracy, precision, selectivity, specificity and robustness. All the parameters examined were within the acceptance limits. The stability-indicating power of the proposed method was proved by subjecting the drugs to hydrolytic (acid and base), oxidative, photolytic and dry heat stress conditions. The developed method was found to be suitable for routine analysis of aspirin and pravastatin simultaneous in the presence of its stress degradation products.

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Determination of pravastatin in tablets by capillary electrophoresis

Cited by 11 publications

References 18 publications

Stability Study of Pravastatin Under Hydrolytic Conditions Assessed by HPLC

Stability Study of Pravastatin Under Hydrolytic Conditions Assessed by HPLC

Pravastatin′in Camımsı Karbon Elektrot üzerinde Kare-dalga Voltametrisi ile İlaç Formülasyonunda Tayini

Stability Indicating HPLC Method for the Simultaneous Quantification of Aspirin and Pravastatin in bulk and Tablets: Method Development and Validation

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