Determination of prohibited ketone flavors in infant’s cosmetics by high performance liquid chromatography-tandem mass spectrometry

Abstract

A rapid screening method of liquid chromatography-tandem mass spectrometry (LC-MS/MS) for five banned ketone fragrances in infant cosmetics has been established. The sample was ultrasonically extracted with acetonitrile, concentrated by nitrogen blowing. Methanol and 0.1% formic acid aqueous solution were used as mobile phases, and separated by gradient elution of HP C18 chromatographic column, and qualitative and quantitative by mass spectrometer. The results showed that the 5 banned ketone fragrances presented a good linear relationship within the mass concentration range of 0.5ug/kg∼50.0ug/kg, and the correlation coefficient r2>0.9983; the detection limit was 0.03ug/kg∼6.25ug/kg, and the limit of quantification is 0.1ug/kg∼ 0.5ug/kg; the average recovery rate of standard addition is between 84.3%∼ 100.6%, and the RSD is between 1.3%∼3.8%. This LC-MS/MS method is suitable for the rapid screening of 5 banned ketone fragrances in complex matrix infant cosmetics, and has the advantages of high recovery rate, low detection limit, and good precision. It can be used to further supplement and improve the technical support for hygiene regulations and quality supervision of banned ketones in cosmetics infant’s cosmetics.