Determination of propisomide, a new antiarrhythmic agent, in biological samples by gas chromatography with a thermionic detector

Necciari, J.; Mery, Domingo; Sales, Y.; Berthet, D.; Cautreels, W.

doi:10.1016/s0378-4347(00)84029-3

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1987

1996

Publication Types

Select...

Article3

Book1

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

HPLC measurement of penticainide and desalkylpenticainide in biological fluids

Walker

Flanagan

Holt

1987

Biomedical Chromatography

View full text Add to dashboard Cite

A simple HPLC method has been developed to measure the antiarrhythmic agent penticainide and its N-desalkyl metabolite in biological fluids. Solvent extraction of a small (200 microL) sample volume with direct analysis of the extract is used to measure the plasma and urinary concentrations of these compounds attained during chronic therapy, although a larger sample volume (1.0 mL) and prior concentration of the extract are required for single oral dose work. In each case chromatographic analysis is performed using a microparticulate (5 microns) silica column and methanolic ammonium perchlorate (10 mM, pH 6.7) as eluent with UV detection (260 nm). No endogenous sources of interference have been encountered and potential interference from other drugs is minimal.

show abstract