Determination of residual amounts ofO-IsobutylS-2-(N,N-Diethylamino)ethyl methylphosphonate in decontaminating solutions by gas chromatography

Stan'kov, I. N.; Sergeeva, A. A.; Derevyagina, I. D.

doi:10.1007/bf02756092

Cited by 2 publications

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“…Analysis of VX or its Russian analogue O -isobutyl S -(2-diethylaminoethyl) methylphosphonothiolate (R-VX; Figure ) is not a problem by itself, and several methods are now documented in the scientific literature for its selective and specific detection in liquid organic or aqueous matrixes (with liquid chromatographic separation or organic solvent extraction prior to gas chromatographic analysis). These methods involve gas chromatographic separation with phosphorus-selective detection or mass spectrometry, or liquid chromatography hyphenated to mass spectrometry.…”

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Extraction of Nerve Agent VX from Soils

2004

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The development and optimization of a method allowing the extraction of intact organophosphorus chemical warfare agent O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX) from several types of soils are presented here. This involved the selection of an appropriate buffer to bring the sample to a pH close to the pK(a) of VX but sufficiently low to avoid its basic hydrolysis. Buffering with Tris (pH 9) and subsequent extraction of the aqueous layer by a 85:15 (v/v) hexane/dichloromethane mixture allows rapid and sensitive flame photometric detection of VX at spiking levels lower than 10 microg x g(-1), even after 3 months of aging. Extraction yields were close to 60% in complex matrixes. This method also allows recovery and identification of a characteristic degradation product of VX, bis(2-diisopropylaminoethyl) disulfide, which appears to be formed during the aging process. The performance of this method is far better than that of OPCW reference operating procedure, which does not allow extraction of detectable amounts of VX (spiked at 10 microg x g(-1)) in one of the soils used for this study.

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Extraction of Nerve Agent VX from Soils

2004

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“…The industrial hazards associated with the production and handling of MEA are skin and eye irritation [1,2]. The U.S. National Institute of Occupational Safety and Health (NIOSH) has adopted an exposure limit of 7.5 mg/m 3 (7.5 ng/mL, 3 ppm) for MEA as time-weighted average values [3], and several analytical methods have been reported for the determination of MEA in air samples [4][5][6][7][8][9][10].…”

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confidence: 99%

“…Derivatization of the target analyte is a method of choice to enhance the sensitivity, and a wide variety of derivatization reagents and the corresponding derivatization reactions have been developed [6][7][8][9][10][11][12][13][14][15][16][17]. Introducing a derivatization reaction before the analysis, the detectivity and sensitivity can be significantly improved.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Derivatization and Extraction of Volatile Amines with Fiber-Packed Needle and Subsequent Analysis in Gas Chromatography

et al. 2018

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A needle-type sample preparation device packed cyclohexanone-coated fibers as an extraction medium has been developed for the gas chromatographic (GC) analysis of volatile amines in air samples. For a simultaneous derivatization/extraction of monoethanolamine (MEA), a fiber-packed needle was employed, where a bundle of heat resistant filaments, Zylon, poly(p-phenylene-2,6-benzobisoxazole) was packed longitudinally into the specially-designed needle. To the needle-type device, cyclohexanone was loaded in the preconditioning process. Gaseous MEA was sampled by a vacuum air sampler connected to the needle, and a simultaneous derivatization/extraction was carried out therein. Desorption of MEA derivative was successfully made at a heated GC injection port without using any desorption solvent. Introducing the simultaneous derivatization with cyclohexanone, the sensitivity was significantly improved, allowing a more sensitive detection of volatile amines. Taking advantage of the specially-designed needle, the needle was able to be stored for several days at room temperature after the sampling, where the derivatives of the volatile amines were stably trapped on the surface of the Zylon filaments in the needle.

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Determination of residual amounts ofO-IsobutylS-2-(N,N-Diethylamino)ethyl methylphosphonate in decontaminating solutions by gas chromatography

Cited by 2 publications

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Extraction of Nerve Agent VX from Soils

Extraction of Nerve Agent VX from Soils

Simultaneous Derivatization and Extraction of Volatile Amines with Fiber-Packed Needle and Subsequent Analysis in Gas Chromatography

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