Determination of rice herbicides, their transformation products and clofibric acid using on-line solid-phase extraction followed by liquid chromatography with diode array and atmospheric pressure chemical ionization mass spectrometric detection

Santos, Teresa Cristina Rodrigues dos; Rocha, Júlio César; Barceló, Damià

doi:10.1016/s0021-9673(00)00100-x

Cited by 77 publications

(23 citation statements)

References 21 publications

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“…High-performance liquid chromatography (HPLC) is preferred with various detection systems including ultraviolet (UV) [20][21][22][23], diode array detection (DAD) [23][24][25][26], MS [27,28] and tandem mass spectrometry (MS n ) [29], and fluorescence detection (FLD) [30]. Generally, LC-MS techniques are considered superior to all the above-mentioned detection techniques, in terms of specificity and sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Determination of Deltamethrin in Mice Plasma and Immune Organs by Simple Reversed-Phase HPLC

Kumar¹,

Dubey²,

Kant³

et al. 2016

Acta Chromatographica

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Deltamethrin, a well-known type 2 synthetic pyrethroid insecticide, is a widespread environmental toxicant. It has potential to accumulate in body fluids and tissues due to its lipophilic characteristics. The immune system is among the most sensitive targets regarding toxicity of environmental pollutants. Various methods are available in the literature to analyze deltamethrin (DLM) concentration in plasma and tissues, but regarding the immune organs, only one gas chromatography–tandem mass spectrometry (GC–MS/MS) method (on spleen tissues) has been reported. In the present investigation, a rapid and sensitive high-performance liquid chromatography (HPLC) method has been developed and validated to determine DLM concentration in plasma, thymus, and spleen using zaleplone as an internal standard. Liquid chromatography (LC) separation is performed on an Agilent Zorbax® C8 column (250 mm × 4.6 mm, i.d., 5 μm) with isocratic elution using a mobile phase consisting of acetonitrile–5 mM KH2PO4 (70:30, v/v) at a flow rate of 1 mL min−1. The lower limit of quantification (LLOQ) for DLM is 10 ng mL−1 (plasma, thymus, and spleen). The method has been validated in terms of establishing linearity, specificity, sensitivity, recovery, accuracy, and precision (intra- and inter-day) and stabilities study. This validated method was successfully applied to a pharmacokinetic and tissue distribution study of DLM in mice.

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Section: Introductionmentioning

confidence: 99%

Determination of Deltamethrin in Mice Plasma and Immune Organs by Simple Reversed-Phase HPLC

Kumar¹,

Dubey²,

Kant³

et al. 2016

Acta Chromatographica

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“…Others extraction techniques, which usually are faster and consume smaller volumes of organic solvent, have been developed for some food samples, such as supercritical fluid extraction, 6 solid-phase microextraction 7 and solid-phase extraction. 8 Multiresidue methods for pesticides analysis were discussed by Ahmed,9 who presented eight techniques for sample preparation.…”

Section: Introductionmentioning

confidence: 99%

“…This method usually uses a relatively small sample blended in a mortar (or glass beaker) with a pestle, using a solid phase in a four-to-one ratio of solid phase to sample. 16 The solid phase, such as silica, often has been derivatized to produce a bound organic phase, such as C 8 or C 18 , on its surface. The solid serves as a shearing force during the blending with a mortar and pestle to disrupt the gross architecture of the sample, breaking the material into smaller pieces.…”

Section: Introductionmentioning

confidence: 99%

Analysis of pesticide residues in rice using matrix solid-phase dispersion (MSPD)

Dórea¹,

Sobrinho²

2004

J. Braz. Chem. Soc.

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Este trabalho apresenta um método multirresíduo de extração por dispersão da matriz em fase sólida (MSPD) para quantificação de dois inseticidas organofosforados (malation e paration metílico) e um organoclorado (β-endosulfan) em arroz por cromatografia gasosa de alta resolução com detector por captura de elétrons. Experimentos foram realizados com adição de pesticidas na amostra, variando quantidades de amostra e de suporte, tipo de suporte e solvente de eluição. A eficiência do método proposto foi demonstrada pelos valores médios de recuperação entre 75,5% e 116,0%, com valores de desvio padrão relativo entre 0,5% e 10,9%, obtidos nas análises de recuperação com amostras fortificadas nos níveis de 0,5 a 10,0 mg kg -1 . Os limites de detecção foram de 20 a 105 pg para os pesticidas estudados. Arroz comercial foi analisado para a aplicação do método.This work reports a multi-residue extraction method based on matrix solid-phase dispersion (MSPD) and capillary gas chromatography -electron capture detection for quantification of two widely used organophosphorus insecticides (malathion and parathion-methyl) and an organochlorine pesticide (β-endosulfan) in rice. A set of experiments was done with a spiked matrix with a standard mix, varying sample and solid phase amounts, solid phase and eluting solvent. Analyses of fortified rice samples were performed at different levels (0.5-10.0 mg kg -1 ). Mean recoveries from three replicates ranged from 75.5% to 116.0%, with coefficients of variation from 0.5% to 10.9%. The limit of detection was in the range of 20 to 105 pg for the pesticides. Commercial rice was analyzed for method application.

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“…Os métodos de análise do 2,4-D por CL costumam ser mais simples e rápidos, se comparados com sua determinação por CG 12 . Vários métodos baseados em CL determinam simultaneamente o herbicida e seu principal produto de degradação, o 2,4-DCF, em amostras de água 13 , embora apenas dois métodos sejam citados para esta análise simultânea em amostras de solo: (i) o primeiro utilizando compostos radiomarcados, apresentado pela Agência de Proteção Ambiental dos Estados Unidos (US-EPA) e (ii) o segundo consistindo de uma simples extração seguida da análise cromatográfica com detecção por UV 14 . Devido à sua ampla utilização, o conhecimento e a avaliação dos principais métodos de determinação do 2,4-D em amostras ambientais são de fundamental importância.…”

Section: Introductionunclassified

Breve revisão de métodos de determinação de resíduos do herbicida ácido 2,4-diclorofenoxiacético (2,4-D)

Júnior¹,

Santos²,

Nunes³

et al. 2003

Quím. Nova

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Determination of rice herbicides, their transformation products and clofibric acid using on-line solid-phase extraction followed by liquid chromatography with diode array and atmospheric pressure chemical ionization mass spectrometric detection

Cited by 77 publications

References 21 publications

Determination of Deltamethrin in Mice Plasma and Immune Organs by Simple Reversed-Phase HPLC

Determination of Deltamethrin in Mice Plasma and Immune Organs by Simple Reversed-Phase HPLC

Analysis of pesticide residues in rice using matrix solid-phase dispersion (MSPD)

Breve revisão de métodos de determinação de resíduos do herbicida ácido 2,4-diclorofenoxiacético (2,4-D)

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