Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals

Patil, Mithun Vishwanath K.; Kandhare, Amit D.; Ghosh, Pranab; Bhise, Sucheta D.

doi:10.1007/s13596-012-0072-4

Cited by 30 publications

(13 citation statements)

References 29 publications

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“…This elevated level of ROS downregulates copper-zinc-SOD enzyme activity along with GSH concentration in myocytes. It caused significant loss of myocardial integrity and necrosis [8,[65][66][67]. Superoxide anions and their derivatives including hydroxyl radicals are the most abundantly generated ROS in cardiac myocytes, which cause peroxidation of the lipid membrane [68].…”

Section: Discussionmentioning

confidence: 99%

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Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats

Visnagri

Kandhare

Ghosh

et al. 2013

Cardiovascular Endocrinology

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Aim The aim of this study was to investigate the effect of bosentan (25, 50, 100 mg/kg) on left ventricular contractile function, cardiac fibrosis, and oxidative stress in pressure overload-induced cardiac hypertrophy in rats.Methods Male rats (200-250 g) were assigned into various groups, namely, sham, aortic constriction, aortic constriction + bosentan (25, 50, and 100 mg/kg), and sham + bosentan (100 mg/kg). Myocardial hypertrophy was produced by constriction of the abdominal aorta. Four weeks after treatment with bosentan (25, 50, and 100 mg/kg perorally), the left ventricular contractile function was measured using a Millar catheter and ECG was carried out.Results Treatment with bosentan (50 and 100 mg/kg perorally) significantly and dose-dependently (P < 0.01 and <0.001) restored hemodynamic parameters including ECG, blood pressure, and left ventricular function. It also significantly elevated the levels of biochemical markers (P < 0.001), that is, superoxide dismutase, reduced glutathione, and membrane-bound inorganic phosphate enzymes like Na + -K + -ATPase and Ca 2 + -ATPase. The elevated levels of creatine kinase-MB and lactate dehydrogenase enzymes, as well as the activities of malondialdehyde and tumor necrosis factor-a, were significantly attenuated (P < 0.05 and <0.001) by bosentan (50 and 100 mg/kg perorally) treatment. An upregulation in the mRNA expression of endothelin-1 was significantly (P < 0.05 and <0.001) attenuated by bosentan (50 and 100 mg/kg perorally) treatment. Histological aberration induced after pressure overload was restored by bosentan treatment.Conclusion Bosentan attenuates the development of cardiac hypertrophy by blocking the endothelin-1 receptor and improving left ventricular function; it also ameliorates endogenous biomarkers in pressure overload-induced cardiac hypertrophy in rats. Cardiovasc

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Section: Discussionmentioning

confidence: 99%

“…A wide range of animal studies have reported that an elevated level of oxidative stress leads to myocardial remodeling and dysfunction [7][8][9]. Remodeling and hypertrophy of cardiomyocytes, apoptosis, and fetal gene expression-like changes may occur because of the increase in oxidative stress [10,11].…”

Section: Introductionmentioning

confidence: 99%

Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats

Visnagri

Kandhare

Ghosh

et al. 2013

Cardiovascular Endocrinology

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“…[ 23 24 ] It has been acknowledged that diseases associated to oxidative stress can be treated by consumption of dietary antioxidants. [ 25 26 27 28 29 ] It is well-demonstrated that antioxidant defense system is modulated by scavenging free radicals that are known to exert by isolated bioactive moieties.…”

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Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats

et al. 2015

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Background:Renal artery occlusion (RAO) induced hypertension is a major health problem associated with structural and functional variations of the renal and cardiac vasculature. Naringin a flavanone glycoside derived possesses metal-chelating, antioxidant and free radical scavenging properties.Objective:The objective of this study was to investigate the antihypertensive activity of naringin in RAO induced hypertension in rats.Material and Methods:Male Wistar rats (180-200 g) were divided into five groups Sham, RAO, naringin (20, 40 and 80 mg/kg). Animals were pretreated with naringin (20, 40 and 80 mg/kg p.o) for 4 weeks. On the last day of the experiment, left renal artery was occluded with renal bulldog clamp for 4 h. After assessment of hemodynamic and left ventricular function various biochemical (superoxide dismutase [SOD], glutathione [GSH] and malondialdehyde [MDA]) and histological parameters were determined in the kidney.Results:RAO group significantly (P < 0.001) increased hemodynamic parameters at 15, 30 and 45 min of clamp removal. Naringin (40 and 80 mg/kg) treated groups showed a significant decrease in hemodynamic parameters at 15 min. after clamp removal that remained sustained for 60 min. Naringin (40 and 80 mg/kg) treated groups showed significant improvement in left ventricular function at 15, 30 and 45 min after clamp removal. Alteration in level of SOD, GSH and MDA was significantly restored by naringin (40 and 80 mg/kg) treatment. It also reduced histological aberration induced in kidney by RAO.Conclusion:It is concluded that the antihypertensive activity of naringin may result through inhibition of oxidative stress.

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“…These consequences caused an alteration in tissue permeability and deactivation of membrane-bound receptors. Additionally, excessive synthesis of NO plays a key role in oxidative damage via interacting with superoxide to generate the peroxynitrite (Kandhare et al, 2016[ 65 ]; Kumar et al, 2014[ 73 ]; Patil et al, 2012[ 94 ]). It has been suggested that antioxidants may play an important role in abating some hazards which are associated with elevated oxido-nitrosative stress (Devkar et al, 2016[ 31 ]; Gosavi et al, 2012[ 41 ]; Kandhare et al, 2017[ 63 ]).…”

Section: Discussionmentioning

confidence: 99%

Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: role of TGF-β/Smads and Ang-1/Tie2 signaling pathways

Kandhare

Mukherjee

et al. 2018

EXCLI Journal; 17:Doc399; ISSN 1611-2156

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Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals

Cited by 30 publications

References 29 publications

Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats

Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats

Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats

Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: role of TGF-β/Smads and Ang-1/Tie2 signaling pathways

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