Determination of rubidium, sodium, calcium and thiamine in a pharmaceutical preparation by capillary isotachophoresis

Fanali, Salvatore; Cristalli, M.; Quaglia, M.G.

doi:10.1016/s0021-9673(00)94147-5

Cited by 12 publications

(5 citation statements)

References 10 publications

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“…CDs continued to be the most common chiral selector used, starting from its first introduction in 1989 354. The interaction between CDs and solute occurs within the cavity by formation of an inclusion complex.…”

Section: Chiral Separationsmentioning

confidence: 99%

Capillary electrophoresis of natural products: Highlights of the last five years (2006–2010)

2011

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An extensive search of the published research and review articles indicated a growing number of works that employed electroseparation techniques. Capillary zone electrophoresis (CZE) and electrokinetic chromatography (EKC), in particular, were found to be popular for the analyses of natural products. This review outlines the important developments in this field over the years, especially during the 2006-2010 period. An overview of the natural product applications such as pharmaceuticals/herbal products, fingerprinting and quality control, food and food contaminants, and toxicological compounds of interest to forensics were presented. Important areas of detection strategies, microchips, sample preconcentration, and chiral separations were also discussed. Hence, quick information was provided on the researches already undertaken and the possibilities of unexplored areas. In addition, fundamental concepts for the understanding of CZE and EKC and their suitability for natural products analyses were briefly discussed.

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Section: Chiral Separationsmentioning

confidence: 99%

Capillary electrophoresis of natural products: Highlights of the last five years (2006–2010)

2011

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“…Whilst ITP has not been applied to the analysis of cations in inorganic explosive residues, conventional scale ITP has been used for analysing similar types of cations, for example alkali metals and ammonium, in other materials such as water samples 18, 19, pharmaceuticals 20 and silage 21. Three main strategies have been devised for allowing the determination of potassium to be made using ITP.…”

Section: Introductionmentioning

confidence: 99%

Determination of the potassium content of explosive residues using miniaturised isotachophoresis

et al. 2010

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A new method has been developed to allow the determination of potassium in post-explosion residues to be made using miniaturised isotachophoresis. The method is based on the use of a caesium leading ion with 4.5 mM 18-crown-6 ether added to retard the potassium to allow reliable determinations to be made. With the conditions selected no interference was noted from other small inorganic cations, such as ammonium, barium, calcium, magnesium, sodium or strontium. The method was successfully applied to the analysis of seven samples containing explosive residues obtained from the unconfined burning of several flash powders. The procedure was found to offer good linearity for potassium determinations over the concentration range of 1.25-150 μg/mL with a coefficient of determination of 0.999 achieved.

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“…Since the pioneering works by Zare et al [1] and Fanali et al [2] and as testified by the very important amount of literature and a number of comprehensive reviews [3][4][5][6][7][8][9][10][11], capillary electrophoresis (CE) has proven to be an excellent alternative to classical chromatographic techniques in this field. The use in very small quantity and in free form of the chiral selector makes it possible to compare the effects of various selectors and afterwards perform routine analyses at lower cost.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of chiral ionic liquids as additives to cyclodextrins for enantiomeric separations by capillary electrophoresis

François¹,

Varenne²,

Juillerat³

et al. 2007

Journal of Chromatography A

118

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A great interest has been drawn these last years towards ionic liquids in analytical chemistry, especially for separation methods. Recent synthesis of chiral ILs opened the way of the evaluation of new potential selectors for enantiomeric separations. This work focused on the evaluation of two chiral ILs (ethyl- and phenylcholine of bis(trifluoromethylsulfonyl)imide) by CE. Particular selectivities are awaited by exploiting unique ion-ion or ion-dipole interactions and by tailoring the nature of the cation and the anion. To evaluate such phenomena, a study was carried out with anti-inflammatory drugs 2-arylpropionic acids as model compounds. The results show that these chiral ILs did not present direct enantioselectivity with regard to these model analytes. The influence of chiral ILs in the electrolytes was then studied in the presence of classical chiral selectors (di- or trimethyl-beta-cyclodextrin). Although no general trend could be established, an increase in separation selectivity and resolution was observed in some cases, suggesting synergistic effects. The complementary determination of apparent inclusion constant values of these IL cations in the used cyclodextrins by affinity CE provided support to the understanding of the phenomena involved.

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Determination of rubidium, sodium, calcium and thiamine in a pharmaceutical preparation by capillary isotachophoresis

Cited by 12 publications

References 10 publications

Capillary electrophoresis of natural products: Highlights of the last five years (2006–2010)

Capillary electrophoresis of natural products: Highlights of the last five years (2006–2010)

Determination of the potassium content of explosive residues using miniaturised isotachophoresis

Evaluation of chiral ionic liquids as additives to cyclodextrins for enantiomeric separations by capillary electrophoresis

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