Determination of Salbutamol Sulfate in pharmaceutical formulation with differential pulse voltammetry using poly(Benzofuran-2-Boronic acid) modified platinum electrode

Abstract

In this study, determination of salbutamol sulfate (SBS) was carried out using poly(benzofuran-2-boronic acid)/platinum electrode (BF2BA/PtE). Polymerization of BF2BA was conducted in acetonitrile (AcN) containing 0.1 M sodium perchlorate (NaClO4) on bare PtE by cyclic voltammetry (CV) method. The electrochemical properties of the prepared polymer electrode were investigated by CV and electrochemical impedance spectroscopy (EIS) techniques in ferricyanide/KNO3 solution. Then, prepared poly(BF2BA/PtE) was used for detection of the SBS. Monomer type, concentration, the number of cycles and scan rate were worked using differential pulse voltammetry (DPV) in citrate-phosphate buffer containing 1.15 mM SBS. The effects of parameters such as electrolyte type, pH effect on SBS DPV responses were studied. The SBS responses of the modified electrodes were also investigated by square wave voltammetry (SWV). The oxidative current peak stem from SBS concentration showed at 0.65V potential and a linear calibration curve was obtained in the range from 50 to 2000 μM SBS concentration. Limit of dedection (LOD), and limit of quantitation (LOQ), was calculated as 49.14 µM and 163.80 µM, respectively. The recovery efficiency for synthetic urine samples was obtained from 91.47 to 110.43% by using BF2BA/PtE.