Determination of selected endocrine disruptors in organic, free-range, and battery-produced hen eggs and risk assessment

Kuzukiran, Ozgur; Dikmen, Begüm Yurdakök; Sevin, Sedat; Şireli, Ufuk Tansel; Iplikcioglu-Cil, Guzin; Filazı, Ayhan

doi:10.1007/s11356-018-3400-5

Cited by 24 publications

(12 citation statements)

References 38 publications

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“…Findings from the biomonitoring based on free-range eggs for PCDD/Fs and dl-PCBs need to be interpreted with caution as eggs are highly sensitive to on-farm pollution (Adamse et al 2017; Kuzukiran et al 2018). In the presence of on-farm secondary sources, the animal contamination could not be exclusively attributed to the contaminated site and these farms should be excluded from sampling.…”

Section: Discussionmentioning

confidence: 99%

Application of a risk-based standardized animal biomonitoring approach to contaminated sites

Scaramozzino

Battisti

Desiato

et al. 2019

Environ Monit Assess

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Biomonitoring has been used to disclose the public health impact of contaminated sites. This study aimed at setting up good practices to apply biomonitoring targeting animal matrixes to design risk-based surveillance and exposure assessment plans. A nine-step protocol targeting farmed animals was devised and tested in three case study areas including (1) a waste dump, (2) a waste incinerator, and (3) a secondary aluminum smelter. Between 2010 and 2012, in each study area, the following 9step best practices were applied: hazard identification, GIS project creation, risk area delimitation, control area selection, receptors (livestock) identification, farms and matrixes selection, sampling study design, on-farm secondary sources exclusion, and statistical and geostatistical analysis. Dairy farms and free-range laying hens were the primary targets: eggs from both risk and control areas and milk from risk areas were sampled and submitted for detection of selected tracking contaminants compatible with the putative sources. Comparison data (risk vs. control) of heavy metal concentrations in eggs were available only for case study 2, whereas egg comparison data of persistent organic pollutants were available for all the riskcontrol pairs. After taking into account potential secondary sources, no concern from metals was arisen, whereas high concentrations of persistent organic pollutants were detected in all risk areas; however, only for the aluminum smelter case study, the contamination was broad and higher in the risk area compared with the control one. The protocol has proved to be easily applicable and flexible to varying contexts and able to provide helpful data to inform risk management decisions.

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Section: Discussionmentioning

confidence: 99%

Application of a risk-based standardized animal biomonitoring approach to contaminated sites

Scaramozzino

Battisti

Desiato

et al. 2019

Environ Monit Assess

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“…Örneklerin ekstraksiyonunda laboratuvarımızda valide edilen yumurtadaki bazı kalıcı organik bileşiklerin belirlenmesine yönelik yöntem değerlendirilip Soxhlete ekstraksiyonuyla birleştirilerek analiz için uyarlandı. 15 Temizleme işleminde kullanılacak kartuşları hazırlamak için 3 ml'lik cam kolonlar önce hekzan ve diklorometan ile temizlendi. Ardından içlerine tabandan tepeye doğru sırasıyla 500 mg C18, 200 mg PSA ve 200 mg MgSO4 konuldu.…”

Section: Ekstraksiyonunclassified

Kuzu Dokularında Endokrin Bozucu Klorlu Kimyasal Varlığının Gaz Kromatografi Kütle Spektrometrisi ile Saptanması ve Cinsiyetin Etkisi

Kuzukiran

Filazı²,

Arslan³

et al. 2019

Journal of Research in Veterinary Medicine

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Vücuttaki endokrin reseptörlerine bağlanıp bunları aktive veya bloke ederek doğal hormonların sentez/parçalanmasını değiştiren endokrin bozucu kimyasallarla ilgili çalışmaların geçmişi 1950'li yıllara kadar gitmektedir. Günümüzde yasaklı olan ama bir dönem yoğun olarak kullanılan organik klorlu pestisitler (OCP), poliklorlu bifeniller (PCB) ve polibromlu difenileterler (PBDE) stabilitelerinin yüksek olması ve yağda birikme özellikleri nedeniyle doğada uzun süre kalmaktadırlar. Bu bileşiklerin biyoakümülasyon ve biyomagnifikasyon nedeniyle gıda zincirine girdikten sonra miktarları sürekli artmaktadır. İnsanların bu kimyasallara maruziyetinin %90'ı bulaşık gıdalarla olmaktadır.

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“…Endocrine disruptors are naturally occurring or man-made substances that can mimic or interfere with the endocrine system at certain doses [ 1 ]. Bisphenol-A (BPA), an endocrine-disrupting chemical (EDC), has capable of binding to both estrogen receptor α (ERα) and estrogen receptor β (ERβ) [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…BPA production which is increased by industrialization, leads to more BPA exposure. Increased BPA levels can cause cancer, birth defects, reproductive, immune, developmental and other organ disorders in humans and other animals [ 1 ]. Increased BPA levels in postmenopausal women have been associated with increased inflammation and oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Nonfunctional adrenal incidentalomas may be related to bisphenol-A

et al. 2020

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Purpose Bisphenol-A (BPA) is an endocrine-disrupting chemical that may affect the hormones and their receptors. The aim of this study is to determine whether BPA has an effect on the development of nonfunctional adrenal incidentaloma (NFAI). Methods Fifty patients who were admitted to endocrinology outpatient clinics and diagnosed as NFAI were included in the study. Fifty healthy people without adrenal mass and adrenal pathology in the upper abdominal computerized tomography or magnetic resonance imaging were also included as control group. Age, gender and body mass index of the study groups were similar. The serum samples for BPA were stored at −80 °C in refrigerator until working in the lab. Serum BPA levels were measured using ELISA technique. Results Mean serum BPA level was 7.06 ± 3.96 ng/ml in NFAI patients and 4.79 ± 3.01 ng/ml in control group. Serum BPA level was significantly higher in NFAI group than control group ( p = 0.001). Serum BPA levels were also found to be significantly higher in women with NFAI than in men with NFAI ( p = 0.019). Conclusions The mechanisms of NFAI development have not been clarified yet. Increased BPA exposure with developed industrialization may play a role in NFAI formation. For the reduction of BPA exposure, the use of plastic prepacked products, plastic containers, and safety measures are essential for public health.

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Determination of selected endocrine disruptors in organic, free-range, and battery-produced hen eggs and risk assessment

Cited by 24 publications

References 38 publications

Application of a risk-based standardized animal biomonitoring approach to contaminated sites

Application of a risk-based standardized animal biomonitoring approach to contaminated sites

Kuzu Dokularında Endokrin Bozucu Klorlu Kimyasal Varlığının Gaz Kromatografi Kütle Spektrometrisi ile Saptanması ve Cinsiyetin Etkisi

Nonfunctional adrenal incidentalomas may be related to bisphenol-A

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