Determination of selenium and iodine in human thyroids

Murillo, Miguel; Carrión, Nereida; Quintana, Mercedes; Sanabria, Georgia; Ríos, Manuel; Duarte, Leopoldo; Ablan, Franklin

doi:10.1016/j.jtemb.2005.07.005

Cited by 19 publications

(12 citation statements)

References 13 publications

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“…The total iodine content in whole thyroid glands (Figure 3) is substantially higher than in human thyroids, where total iodine in the whole glands is 3.44 ± 1.11 mg/kg [45]. In accordance with the previous results, only iodide was detected in the liver extracts (Figure 4), whereas the presence of iodate was not confirmed [23].…”

Section: Discussionsupporting

confidence: 85%

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The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

Rýdlová

Růnová

Száková

et al. 2017

BioMed Research International

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The response of nutrient status and biochemical processes in (i) Wistar and (ii) spontaneously hypertensive (SHR) rats upon dietary intake of selenium- (Se-) enriched defatted rapeseed (DRS) and/or vitamin E fortification was examined to assess the health benefit of DRS in animal nutrition. Twenty-four individuals of each type of rat were used: The control group was fed with an untreated diet (Diet A). In Diets B and C, soybean meal was replaced with defatted DRS, which comprised 14% of the total diet. The selenized DRS application resulted in ~3-fold increase of Se content in the diet. Diet C was also fortified with the addition of vitamin E, increasing the natural content by 30%. The Se content of the blood and kidneys tended to increase in the DRS groups, where the changes were significant (P < 0.05) only in the case of SHR rats. The iodine (I) content and the proportion of iodide in rat livers indicated a lower transformation rate of iodide into organoiodine compounds compared to the control. Slight and ambiguous alterations in the antioxidative response of the rat were observed in the DRS groups, but the addition of vitamin E to the diet helped to moderate these effects.

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Section: Discussionsupporting

confidence: 85%

“…The lowest selenium concentration for a single thyroid gland sample was 0.51 ± 0.05 mg/kg and the highest was 1.49 ± 0.20 mg/kg [45]. In our case, however, the Se content of the thyroid glands was not determined because of an insufficient amount of material for these analyses.…”

Section: Discussionmentioning

confidence: 71%

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

Rýdlová

Růnová

Száková

et al. 2017

BioMed Research International

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“…Several selenoproteins are expressed in thyroid follicular cells (24)(25)(26). Among these, two isoforms of iodothyronine 5'-deiodinase (type1 and type2, DIO1 and DIO2), which produce active thyroid hormone (4); the thioredoxin reductase type 1 (27); the selenoprotein P (27); and three isoforms of glutathione peroxidase, two of which (GPX1 and GPX4) protect thyroid follicular cells from hydrogen peroxide generated by thyroid peroxidase (4), and the third (GPX3) which is present into the lumen, where seems to modulate hydrogen peroxide levels (28).…”

Section: Role Of Selenium In Thyroid Physiologymentioning

confidence: 99%

Selenium in the thyroid: physiology and pathology

Fusco¹,

Nettore²,

Colao³

et al. 2013

REM

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SummarySelenium (Se) is a trace element that plays a critical role in several processes for human health. The thyroid is the organ with the highest Se content per gram of tissue; in thyroid follicular cells, Se acts as antioxidant by contrasting the production of the reactive oxygen species that are generated during thyroid hormones biosynthesis. In addition, Se is part of the active site of the deoidinases, the enzymes responsible for thyroid hormones activation and inactivation. Herein, the effects of Se supplementation in patients with thyroid related disorders have been reviewed on the basis of the studies published on this issue.

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“…These methods include gas chromatography-electron capture detection (GC-ECD) [3] , atomic absorption spectroscopy (AAS) [4][5][6][7] , atomic fluorescence spectroscopy (AFS) [8] , inductively coupled plasma optical emission spectrometry (ICP-OES) [9] , hydride generation system and atomic fluorescence spectrometer (HG-AFS) [10] , hydride generation atomic fluorescence spectrometer (HG-AFS) [11] , stripping voltammetry [12] and integrated coupled plasma mass spectroscopy. [13] From the literature survey, it is clear that, different instrumental techniques are available for the determination of selenium (IV) in variety of samples.…”

Section: Introductionmentioning

confidence: 99%

Solvent Extraction, Spectrophotometric Determination of Selenium (Iv) at Microgram Level Using O-Methylphenyl Thiourea as a Sensitive Reagent: Analysis of Pharmaceuticals, Synthetic Mixtures and Real Samples

Kuchekar¹

2017

WJPPS

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Determination of selenium and iodine in human thyroids

Cited by 19 publications

References 13 publications

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation

Selenium in the thyroid: physiology and pathology

Solvent Extraction, Spectrophotometric Determination of Selenium (Iv) at Microgram Level Using O-Methylphenyl Thiourea as a Sensitive Reagent: Analysis of Pharmaceuticals, Synthetic Mixtures and Real Samples

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