Determination of serum anti‐Müllerian hormone concentrations for the diagnosis of granulosa‐cell tumours in mares

Ball, Barry A.; Almeida, Juliana Lopes; Conley, Alan J

doi:10.1111/j.2042-3306.2012.00594.x

Cited by 63 publications

(68 citation statements)

References 28 publications

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“…Anti‐Müllerian hormone has been recently reported as a diagnostic marker for GCT in mares (Ball et al . , ; Almeida et al . ) but an assay for this hormone was not available at the time of the study.…”

Section: Discussionmentioning

confidence: 99%

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Granulosa cell tumours in the mare: A review of 52 cases

Sherlock

Lott-Ellis

Bergren

et al. 2015

Equine Veterinary Education

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Summary Granulosa cell tumour (GCT) is reported to be the most common ovarian neoplasm in the mare. A multicentre retrospective study evaluating the medical records of horses undergoing ovariectomy for treatment of a GCT was undertaken, documenting the presenting clinicopathological features, treatment and outcome. Follow‐up information was obtained by telephone questionnaire. Fifty‐two mares were included. Most presented with behavioural/reproductive abnormalities, including stallion‐like behaviour (50%), aggression (31%), prolonged oestrus or nymphomania (19%), and persistent anoestrus (8%). Most (93%) affected ovaries had a multilocular appearance when examined ultrasonographically. Only 60% of horses with histopathologically confirmed GCTs demonstrated elevations in serum inhibin concentrations. Twenty‐five percent of horses had histopathologically confirmed bilateral GCTs. Ninety‐four percent of horses that underwent ovariectomy were discharged from the hospital. Standing laparoscopic ovariectomies had a lower complication rate (34%) than other surgical methods. Long‐term complications were uncommon (11%). In conclusion, histopathologically confirmed GCTs can occur in the presence of normal serum inhibin concentrations. The high prevalence of bilateral GCTs indicates that thorough evaluation of the contralateral ovary is necessary. Surgical ovariectomy for treatment of GCTs has favourable short‐ and long‐term outcomes. Standing laparoscopic ovariectomy may be associated with a lower complication rate than other surgical methods.

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Section: Discussionmentioning

confidence: 99%

“…Recently, anti‐Müllerian hormone has been reported as a diagnostic marker for GCT (Ball et al . , ).…”

Section: Introductionmentioning

confidence: 99%

Granulosa cell tumours in the mare: A review of 52 cases

Sherlock

Lott-Ellis

Bergren

et al. 2015

Equine Veterinary Education

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“…However, recently, in mares, it was found that the sensitivity of anti-Müllerian hormone (AMH) for detection of GCTs was significantly higher than that of either inhibin or testosterone (Ball et al 2013). Similarly, in cattle, the measurement of plasma AMH concentration was identified as a more reliable and sensitive method to diagnose GCTs than that of the measurement of INH or ovarian steroids (Kitahara et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Clinical diagnosis of bovine granulosa cell tumour in a Holstein cow using plasma anti-Müllerian hormone concentration: a case report

Okawa

Tomiki

Ishida³

et al. 2016

Journal of Applied Animal Research

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A 23-month-old Holstein cow had a multi-cystic and enlarged left ovary detected by rectal palpation and ultrasonography. The plasma anti-Müllerian hormone (AMH) concentration was 36.5 ng/ml, which is higher than normal. From the clinical history and plasma AMH levels, a granulosa cell tumour (GCT) was diagnosed. Affected ovary was removed by ovariectomy, and GCT was confirmed with histopathological findings. The cow was artificially inseminated at 145 days after ovariectomy, and conceived. The plasma AMH concentration declined at 224 days after removal of affected ovary to less than 0.1 ng/ml, and recovery of fertility was achieved. In conclusion, measurement of plasma AMH levels combined with rectal palpation and ultrasonography examinations could be useful in clinical diagnosis of bovine GCT. ARTICLE HISTORY

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“…In mares, testosterone and inhibin assays have been utilised to enhance non-surgical ante-mortem diagnosis (McCue et al 2006). More recently AMH has been used as a highly sensitive and specific assay in both mares (Ball et al 2008(Ball et al , 2013 Lactogenesis in the absence of pregnancy has previously been reported in a ewe with GTCT (Gardner et al 2005). There are several reports of transient lactogenesis associated with GTCT in dairy cattle (Short et al 1963;Whitacre et al 1988;Palmer et al 2005), and in dairy cows transported by boat (Mansell et al 2014).…”

Section: Spontaneous Lactogenesis and Galactopoeisis In A Virgin Dairmentioning

confidence: 99%

Spontaneous lactogenesis and galactopoeisis in a virgin dairy heifer with evidence of a granulosa theca cell tumour

Gunn

Reader

2015

New Zealand Veterinary Journal

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Determination of serum anti‐Müllerian hormone concentrations for the diagnosis of granulosa‐cell tumours in mares

Abstract: Measurement of serum AMH concentrations can be used for diagnosis of GCTs in the mare. As serum AMH concentrations do not vary significantly during the oestrous cycle or pregnancy, interpretation of these results is not confounded by these physiological states.

Cited by 63 publications

References 28 publications

Granulosa cell tumours in the mare: A review of 52 cases

Granulosa cell tumours in the mare: A review of 52 cases

Clinical diagnosis of bovine granulosa cell tumour in a Holstein cow using plasma anti-Müllerian hormone concentration: a case report

Spontaneous lactogenesis and galactopoeisis in a virgin dairy heifer with evidence of a granulosa theca cell tumour

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