Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage

Chen, Sheng; Chen, Xiachan; Lu, Xiaohui; Qian, Song-Quan; Ruan, Zhanwei

doi:10.1016/j.cca.2019.02.009

Cited by 16 publications

(10 citation statements)

References 37 publications

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“…Inflammatory monocyte-macrophages (IMMs) and neutrophils are major sources of cytokines and AGING chemokines involved in the pathogenicity of SARS-CoV-2 [50]. Some of these factors represent classical inflammatory biomarkers associated with secondary brain injury following cerebral hemorrhage and may have prognostic value in hemorrhagic stroke patients [51][52][53][54][55]. Lattanzi et al recently reviewed available evidence pointing to the relevance of assessing the neutrophil-to-lymphocyte ratio (NLR) to determine inflammatory status in ICH patients [54].…”

Section: Convergence Of Inflammatory Mediatorsmentioning

confidence: 99%

“…Nevertheless, it should be considered that interethnic genomic differences may influence CRP status and its predictive values on different stroke phenotypes. Another marker, namely serum neutrophil gelatinaseassociated lipocalin (NGAL), a member of the lipocalin family of proteins associated with transport of small hydrophobic molecules, plays an important role in the innate immune response and has also been identified as an independent predictor for outcome following hemorrhagic stroke [51]. Given that these inflammatory biomarkers have been associated with both SARS-CoV-2-related cytopathic effects and hemorrhagic stroke outcome, it would be worthwhile to explore which changes in inflammatory biomarkers occur after hemorrhagic stroke and their predictive value in patients with and without COVID-19.…”

Section: Convergence Of Inflammatory Mediatorsmentioning

confidence: 99%

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Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients

Wang

Tang

Fan

et al. 2020

Aging

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has been recognized as a new human disease [1]. The causative agent was identified as a novel coronavirus strain, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group (CSG) [2]. The mortality rate of SARS-CoV-2 is lower than those of Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) [3]. However, SARS-CoV-2 spreads more rapidly than MERS-CoV and SARS-CoV because viral load and infectiousness peak before or around the time of symptom onset, i.e. much earlier than for both MERS-CoV and SARS-CoV [3]. The high transmissibility of SARS-CoV-2 is denoted by a basic reproduction number (R0) of 3.39 over the whole epidemic period [4]. Moreover, COVID-19 can be transmitted by asymptomatic carriers during the incubation period [4-7], probably because they carry viral loads similar to those of symptomatic patients [8]. Although further studies are warranted to ascertain the epidemiological significance of www.aging-us.com

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Section: Convergence Of Inflammatory Mediatorsmentioning

confidence: 99%

Section: Convergence Of Inflammatory Mediatorsmentioning

confidence: 99%

Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients

Wang

Tang

Fan

et al. 2020

Aging

View full text Add to dashboard Cite

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“…After brain trauma, NGAL sequesters iron, leading to damage of cerebral tissue [37]. The study by Chen revealed significantly increased NGAL serum concentrations in patients with adverse outcomes observed within 90 days after SAH [38]. Likewise, observations performed by Zhao in patients after TBI showed a positive correlation between high NGAL expression and the severity of the injury [39].…”

Section: Discussionmentioning

confidence: 93%

Biomarkers Facilitate the Assessment of Prognosis in Critically Ill Patients with Primary Brain Injury: A Cohort Study

Duda

Wiórek

Krzych

2020

IJERPH

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Primary injuries to the brain are common causes of hospitalization of patients in intensive care units (ICU). The Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system is widely used for prognostication among critically ill subjects. Biomarkers help to monitor the severity of neurological status. This study aimed to identify the best biomarker, along with APACHE II score, in mortality prediction among patients admitted to the ICU with the primary brain injury. This cohort study covered 58 patients. APACHE II scores were assessed 24 h post ICU admission. The concentrations of six biomarkers were determined, including the C-reactive protein (CRP), the S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase 9 (MMP-9), and tissue inhibitor of metalloproteinase 1 (TIMP-1), using commercially available ELISA kits. The biomarkers were specifically chosen for this study due to their established connection to the pathophysiology of brain injury. In-hospital mortality was the outcome. Median APACHE II was 18 (IQR 13–22). Mortality reached 40%. Median concentrations of the CRP, NGAL, S100B, and NSE were significantly higher in deceased patients. S100B (AUC = 0.854), NGAL (AUC = 0.833), NSE (AUC = 0.777), and APACHE II (AUC = 0.766) were the best independent predictors of mortality. Combination of APACHE II with S100B, NSE, NGAL, and CRP increased the diagnostic accuracy of mortality prediction. MMP and TIMP-1 were impractical in prognostication, even after adjustment for APACHE II score. S100B protein and NSE seem to be the best predictors of compromised outcome among critically ill patients with primary brain injuries and should be assessed along with the APACHE II calculation after ICU admission.

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“…A total of 53 studies reported WBC count 27 – 29 , 44 – 93 in relation to clinical outcome after ICH. Of these, 13 27 , 29 , 49 , 55 , 58 , 59 , 64 , 78 , 82 , 84 , 86 , 91 , 93 studies of 2,453 participants were meta-analysed. Overall, 10 (77%) studies reported WBC at admission, the remainder reporting it within 48 hours after ICH onset.…”

Section: Resultsmentioning

confidence: 99%

Association between circulating inflammatory biomarkers and functional outcome or perihaematomal oedema after ICH: a systematic review & meta-analysis

Kirby,

Barrington,

Sondag

et al. 2023

Wellcome Open Res

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Background Currently, there are no specific medical treatments for intracerebral haemorrhage (ICH), but the inflammatory response may provide a potential route to treatment. Given the known effects of acute brain injury on peripheral immunity, we hypothesised that inflammatory biomarkers in peripheral blood may be associated with clinical outcome following ICH, as well as perihaematomal oedema (PHO), which is an imaging marker of the neuroinflammatory response. Methods We searched OVID Medline and EMBASE on 07 April 2021 for studies of humans with ICH measuring an inflammatory biomarker in peripheral blood and PHO or clinical outcome. Risk of bias was assessed both by using a scale comprising features of the Newcastle-Ottawa Assessment Scale, STROBE-ME and REMARK guidelines, and for studies included in meta-analysis, also by the QUIPS tool.We used random effects meta-analysis to pool standardised mean differences (SMD) if ≥1 study quantified the association between identical biomarkers and measures of PHO or functional outcome. Results Of 8,615 publications, 16 examined associations between 21 inflammatory biomarkers and PHO (n=1,299 participants), and 93 studies examined associations between ≥1 biomarker and clinical outcome (n=17,702 participants). Overall, 20 studies of nine biomarkers (n=3,199) met criteria for meta-analysis of associations between inflammatory biomarkers and clinical outcome. Death or dependency (modified Rankin Scale (mRS) 3‒6) 90 days after ICH was associated with higher levels of fibrinogen (SMD 0.32; 95%CI [0.04, 0.61]; p=0.025), and high mobility group box protein 1 (HMGB1) (SMD 1.67; 95%CI [0.05, 3.30]; p=0.04). Higher WBC was associated with death or dependency at 90 days (pooled SMD 0.27; 95% CI [0.11, 0.44]; p=0.001; but the association was no longer significant when the analysis was restricted to studies with a low risk of bias (pooled SMD 0.22; 95% CI -0.04-0.48). Higher CRP seemed to be associated with death or dependency at 90 days (pooled SMD 0.80; 95% CI [0.44, 1.17]; p<0.0001) but this association was no longer significant when adjusted OR were pooled (OR 0.99 (95% CI 0.98-1.01)). Conclusions Higher circulating levels of, fibrinogen and HMGB1 are associated with poorer outcomes after ICH. This study highlights the clinical importance of the inflammatory response to ICH and identifies additional research needs in determining if these associations are mediated via PHO and are potential therapeutic targets. Registration PROSPERO (CRD42019132628; 28/05/2019).

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Determination of serum neutrophil gelatinase-associated lipocalin as a prognostic biomarker of acute spontaneous intracerebral hemorrhage

Cited by 16 publications

References 37 publications

Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients

Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients

Biomarkers Facilitate the Assessment of Prognosis in Critically Ill Patients with Primary Brain Injury: A Cohort Study

Association between circulating inflammatory biomarkers and functional outcome or perihaematomal oedema after ICH: a systematic review & meta-analysis

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